Protease Current Events | Protease News | 3
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A single mechanism for hypertension, insulin resistance and immune suppression
Many of the 75 million Americans with essential hypertension also develop diabetes and other complications in addition to their high blood pressure, and researchers have discovered a common molecular mechanism in a strain of rat that explains why such metabolic disorders arise together in mammals. view more (2008-06-30)
How Proteins Talk to Each Other
Investigators at Burnham Institute for Medical Research (Burnham) have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). view more (2009-09-22)
Yes-associated protein: Early diagnosis of gastric carcinoma
Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator. view more (2009-09-16)
Cathepsin B increases apoptosis in fulminant hepatic failure
The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. view more (2009-03-20)
The smoking gun: Elastin fragments drive emphysema
Pulmonary emphysema is caused primarily by cigarette smoking, and the underlying cellular mechanisms are thought to involve smoke-induced activation of tissue degrading enzymes known as proteases. view more (2006-02-10)
A new finding in liver transplantation and antifibrinolytics?
Orthotopic liver transplantation (OLT) is associated with severe bleeding and considerable transfusion requirements. There are several reasons for this severe bleeding in OLT. Hemostatic abnormalities remain a major cause. view more (2008-03-13)
Standing up to paraplegia with gene therapy
Elena Rugarli and colleagues from the National Neurological Institute in Milan have used gene therapy to save sensory and skeletal muscle nerve fibers from degeneration in mice with hereditary spastic paraplegia (HSP). view more (2005-12-16)
Resistant HIV quickly hides in infants' cells
New evidence shows that drug-resistant virus passed from mother-to-child can quickly establish itself in infants' CD4+ T cells where it can hide for years, likely limiting their options for future treatment. view more (2007-05-01)
Locking Parasites in Host Cell Could Be New Way to Fight Malaria, Penn Study Shows
Researchers at the University of Pennsylvania have discovered that parasites hijack host-cell proteins to ensure their survival and proliferation, suggesting new ways to control the diseases they cause. view more (2009-04-06)
New study zeroes in on the genetic roots of Alzheimer's
Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimer's disease. Now a new study helps explain why this is so. view more (2007-04-11)
EARLY ASSESSMENT PREDICTS LONG-TERM EFFICACY OF HIV-1 ANTIRETROVIRAL THERAPY (p 1760)
A study in this week's issue of THE LANCET highlights how very early (one week) assessment can reliably predict the long-term effectiveness of antiretroviral therapy for HIV-1. Early assessment of antiretroviral drug efficacy is important for the prevention of the emergence of drug-resistant virus and unnecessary exposure to ineffective and toxic... view more... (2001-11-21)
Cancer cell communication exposed
The discovery, by scientists at Monash University and the Sloan Kettering Cancer Centre in New York, of how communication between cancer cells is controlled has promised new treatment options for malignant tumours. view more (2005-10-31)
ENZYME CONCENTRATIONS AND SKIN DISEASE MAY PREDICT SEVERITY OF REACTIONS TO BEE AND WASP STINGS (p 361)
Raised concentrations of the enzyme tryptase, associated with previously undiagnosed skin disease, may be a predictor of how people will react to bee and wasp stings, reports a study in this week’s issue of THE LANCET. 5% of adults in Europe and the USA have anaphylactic (hypersensitive) reactions to bee and wasp stings. The severity of... view more... (2001-01-31)
Flower power may bring ray of sunshine to cancer sufferers
A mini-protein found in sunflower seeds could be the key to stopping tumors spreading in prostate cancer patients, according to QUT researchers. view more (2008-05-01)
International panel updates treatment guidelines for HIV infection
An evaluation of recent data has led to an update in the guidelines and recommendations for antiretroviral treatment of adult human immunodeficiency virus (HIV) infection, according to an article in the August 6 issue of JAMA, a theme issue on HIV/AIDS. view more (2008-08-04)
New NIST reference material for peptide analysis
The National Institute of Standards and Technology (NIST) has issued its first-ever reference material designed to improve the performance and reliability of experiments to measure the masses and concentrations of peptides in biomolecular samples. view more (2007-05-29)
New molecular insight into amboebic dysentery
In the June 15th issue of G&D, Dr. Sinisa Urban (Johns Hopkins University School of Medicine) and colleagues reveal a potential role for the rhomboid enzyme, EhROM1, in the pathogenesis of the enteric protozoan parasite, E. histolytica. view more (2008-06-16)
HIV drug could be used to prevent cervical cancer, say University of Manchester researchers
Researchers at the University of Manchester are developing a topical treatment against the human papilloma virus (HPV) which is responsible for pre-cancerous and cancerous disease of the cervix as well as other genital malignancies. view more (2006-08-25)
Jefferson scientists discover a key protein regulator of inflammation and cell death
Reporting in the journal Nature, researchers led by Emad Alnemri, Ph.D., professor of Biochemistry and Molecular Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation. view more (2009-01-23)
Enzyme shreds Alzheimer's protein
An enzyme found naturally in the brain snips apart the protein that forms the sludge called amyloid plaque that is one of the hallmarks of Alzheimer's disease (AD), researchers have found. view more (2006-09-21)
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