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Proteasome Current Events | Proteasome News
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Proteasome inhibition affects epigenetic mechanisms
Alcohol consumption causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunoresponse defect, and fibrosis. view more (2009-02-19)
Proteasome activator enhances survival of Huntington's disease neuronal model cells
To function, each living cell needs both to build new and to degrade old or damaged proteins. To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins. view more (2007-02-28)
Diet and lifestyle critical to recovery, says study
Diet and lifestyle may play a much more significant role in a person's ability to respond favourably to certain drugs, including some cancer therapies, than previously understood, say scientists. view more (2008-01-18)
Novel drug preventing protein recycling shows potential for treating leukemia
Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found that a novel targeted therapy effectively treats acute leukemia in animal models by preventing cancer cells from being purged of damaged proteins. view more (2007-04-20)
Studies Suggest New Targets for Tuberculosis Treatments
With the hope of designing more effective treatments for tuberculosis (TB), scientists from the U.S. Department of Energy's Brookhaven National Laboratory and collaborating institutions have published the first detailed reports on the biochemistry and structure of a protein-cleaving complex that is essential to the TB bacterium's survival. view more (2006-03-07)
Outsmarting cancer - new results from novel enzyme inhibitors
Smart drugs that can break the chain of command between enzymes and the genes involved in cell division and cell death are a new way forward in tackling breast cancer, according to Dr Stephen Johnston, a consultant oncologist from The Royal Marsden Hospital, London, UK. He was speaking at a news briefing on Thursday (21 March) at the 3rd European... view more... (2002-03-19)
Protein Sequences: Not So Predictable After All
Scientists have believed for decades that the sequencing of the human genome would automatically yield the sequences of proteins, the functional products of genes, and thus lead to the unraveling of the mechanisms behind human cell biology and disease. However, a paper published in Science today by the Ludwig Institute for Cancer Research (LICR)... view more... (2004-03-01)
St. Jude finds mechanism for faulty protein disposal
A discovery by St. Jude Children's Research Hospital scientists offers new insights into how myeloma cells dispose of defective or excess proteins and could lead to new cancer treatments. view more (2007-12-07)
Drug shows positive responses, low side-effects in multiple myeloma
The second-generation proteasome inhibitor carfilzomib is showing noteworthy response rates and low levels of adverse side effects among multiple myeloma patients in a phase II clinical trial, researchers reported today at the 51st Annual Meeting of the American Society of Hematology. view more (2009-12-07)
MIT finds most complex protein knot ever seen
An MIT team has discovered the most complicated knot ever seen in a protein, and they believe it may be linked to the protein's function as a rescue agent for proteins marked for destruction. view more (2006-09-26)
Researchers Find New Class of Nontoxic Cancer Treatments
A new class of compounds developed by two University of Kentucky researchers shows promise as a nontoxic treatment of some cancers previously treated with toxic chemotherapy, the researchers report today. view more (2007-05-02)
Weill Cornell Researchers Discover New Anti-Tuberculosis (TB) Compounds
Attempts to eradicate tuberculosis (TB) are stymied by the fact that the disease-causing bacteria have a sophisticated mechanism for surviving dormant in infected cells. view more (2009-09-17)
Gene expression profiling of dengue virus infection in cell lines and patients
Researchers at the Novartis Institute for Tropical Diseases and the Genome Institute of Singapore have identified new host genes associated with dengue virus infection, which may open new avenues to developing a drug to treat the disease. view more (2007-11-07)
Self-digestion as a means of survival
In times of starvation, cells tighten their belts: they start to digest their own proteins and cellular organs. The process - known as autophagy - takes place in special organelles called autophagosomes. view more (2009-02-27)
U of M identifies cell line that is resistant to retroviruses, including HIV
Researchers at the University of Minnesota have identified a protein that enables viruses such as HIV to infect cells and spread through the body. view more (2006-10-18)
New pathway could present an intervention point for cancer treatment
A new cellular pathway leads to destruction of a protein that promotes growth of breast, prostate and similar cancers and could provide a new avenue through which to pursue treatment of such diseases. view more (2006-01-27)
Study reveals how cells destroy faulty proteins in cystic fibrosis
The cellular system that degrades faulty proteins created by the cystic fibrosis gene has been identified by University of North Carolina at Chapel Hill scientists. view more (2006-08-11)
Researchers identify new, cancer-causing role for protein
The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth, researchers at The University of Texas M. D. Anderson Cancer Center report in the Aug. 28 edition of Science. view more (2009-08-28)
IKK may act as both inhibitor and promoter of Huntington's disease
The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. view more (2009-12-21)
The Nobel Prize in Chemistry 2004
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2004 "for the discovery of ubiquitin-mediated protein degradation" jointly to view more (2004-10-06)
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