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A new player in the battle against hepatitis prevents inflammation and the death of liver cells
Scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) have again achieved a breakthrough in research on hepatitis.   view more (2005-09-02)

MRC Scientists Unlock One of the Secrets of Inflammation Offering Hope of New Treatments for Arthritis, Asthma and Cancer
Medical Research Council (MRC) scientists, working with colleagues at the University of Oxford, have unravelled the structure and function of a common protein molecule at the heart of the process of inflammation. The discovery, published today (February 27 2004) in Molecular Cell, provides an... view more (2004-02-25)

A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value.   view more (2008-05-21)

In evolutionary arms race, a bacterium is found that outwits tomato plant's defenses, Cornell study finds
An arms race is under way in the plant world. It is an evolutionary battle in which plants are trying to beef up their defenses against the innovative strategies of pathogens.   view more (2007-07-19)

Targeting key proteins of carcinogenesis
Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome. The cell labels the proteins it wants to dispose with Ubiquitin (Ub) in order to avoid the unwanted degradation of still needed proteins.   view more (2007-06-25)

Model for Angelman syndrome developed by University of Texas at Austin biologists
A model for studying the genetics of Angelman syndrome, a neurological disorder that causes mental retardation and other symptoms in one out of 15,000 births, has been developed by biologists at The University of Texas at Austin.   view more (2008-08-15)

Absence of critical protein linked to infertility
Researchers at the University of Illinois at Urbana-Champaign report that experiments involving mice - to be detailed in the Proceedings of the National Academy of Sciences - indicate that the transcription factor protein C/EBPb must be present in the uterus for pregnancy to occur.   view more (2006-01-17)

TANGO - towards faster prognosis of Alzheimer's and Parkinson's diseases?
A large number of diseases - including Alzheimer's disease, Parkinson's disease, and mad cow disease - are the result of proteins that erroneously assume the wrong shape, causing them to stick to each other. This phenomenon is perceptible, but up to now it has been difficult to predict. Researchers... view more (2004-09-13)

First high-res 3D structures of mammalian HSP90 protein solved
Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers.   view more (2007-10-15)

RTS and Syrrx Announce Partnership
RTS Life Science International (RTS) and Syrrx announce a partnership to develop and market high throughput structural biology automation solutions. This will be known as the HTSB Factory™ and it allows the user to set-up hundreds of thousands of experiments for a target and increase the... view more (2003-05-01)

First functional insulin-binding protein in invertebrates
Insulin-like growth factor (IGF) signaling that helps to regulate mammals' growth, metabolism, reproduction and longevity is well documented.   view more (2008-04-15)

Changes in urine could lead to BSE test for live animals
Researchers have demonstrated that protein levels in urine samples can indicate both the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.   view more (2008-09-08)

Scientists identify protein that may promote migraines
A University of Iowa study may provide an explanation for why some people get migraine headaches while others do not. The researchers found that too much of a small protein called RAMP1 appears to "turn up the volume" of a nerve cell receptor's response to a neuropeptide thought to cause... view more (2007-03-09)

The shape of allergy - what makes an allergen an allergen
An enduring mystery for allergy researchers has been the unpredictable distribution of allergens in plants. For example, being allergic to birch pollen can predispose a person to allergy from distantly related plant foods such as celery, apple or soy.   view more (2005-01-07)

NYU scientists identify critical protein complex in formation of cell cilia
An international team led by NYU Cancer Institute have identified a protein complex that regulates the formation of cilia, which are found on virtually all mature human cells and are essential to normal cell function.   view more (2008-08-20)

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.   view more (2007-11-14)

Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
Researchers at Jefferson's Kimmel Cancer Center in Philadelphia have shown that they can effectively kill prostate cancer cells in both the laboratory and in experimental animal models by blocking a signaling protein that is key to the cancer's growth.   view more (2008-02-28)

Physics and biology team up to tackle protein folding debate
A team of researchers from EPFL, (Ecole Polytechnique Fédérale de Lausanne), the University of Lausanne, Northwestern University and Tel Aviv University bring biology and statistical physics together to answer the question of how molecular chaperones fold, unfold and pull proteins... view more (2006-04-04)

Cooling analgesia harnessed to relieve chronic pain
By experimentally activating a special protein involved in mediating sensations of coolness, researchers have made a breakthrough in understanding how the body's nervous system can be stimulated to relieve chronic pain.   view more (2006-08-22)

Study reveals mechanism for cancer-drug resistance
Using the worm Caenorhabditis elegans, researchers at UT Southwestern Medical Center have discovered a mechanism by which cancer cells become resistant to a specific class of drugs.   view more (2006-10-10)

Diverting the damage in diabetes
Scientists from Bristol University have found a molecule which may stop the damage caused by the immune system in diabetes. Dr Neil Williams, an immunologist from the University of Bristol describes the research at the British Society for Immunology’s Congress 2000 in Harrogate today... view more (2000-12-01)

Statistics are insufficient for study of proteins' signal system
Ten years ago great attention was attracted by the discovery that it was possible to demonstrate signal transfer in proteins using statistical methods. In an article in the journal Proceedings of the National Academy of Science (PNAS) Uppsala researchers are now presenting results of experiments... view more (2008-03-27)

'Clumping' protein linked to return of ovarian cancer
Johns Hopkins scientists have discovered that women treated for ovarian cancer are at increased risk of a rapid and potentially fatal recurrence if their tumor cells have high levels of a binding protein that triggers abnormal growth and slows down cell death, both hallmarks of malignancy.   view more (2006-12-18)

Protein complementarity may offer new insights into autoimmune diseases
The discovery of "complementary" antibodies against plasminogen in patients with blood vessel inflammation caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs) may lead to new approaches to research, testing, and treatment of ANCA vasculitis and other autoimmune diseases, suggests... view more (2008-08-14)

Scientists identify molecular structure of key viral protein
Scientists at Northwestern University have determined the molecular structure of a viral protein, the parainfluenza virus 5 fusion (F) protein.   view more (2006-01-05)
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