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Lessons from yeast: A possible cure for Parkinson's disease?
Parkinson disease (PD) is a debilitating and lethal neurodegenerative disease, for which there is currently no cure. It is caused by the progressive loss of nerve cells that produce the chemical dopamine and is characterized by the accumulation of abnormal aggregates of a protein called alpha-syn... view more (2008-08-15)

Clumps of red and white blood cells may contribute to sickle cell disease
It's long been known that patients with sickle cell disease have malformed, "sickle-shaped" red blood cells - which are normally disc-shaped - that can cause sudden painful episodes when they block small blood vessels.   view more (2008-04-29)

Protein aggregates in Lou Gehrig's disease linked to neuron death
French neurologist Jean-Martin Charcot first described amyotrophic lateral sclerosis (ALS) in 1869, but, nearly 140 years later, little is known about the cause of the devastating neurodegenerative disease, and there is no cure   view more (2005-10-27)

NIST trumps the clumps: Making biologic drugs safer
Scientists at the National Institute of Standards and Technology (NIST) have developed a technique to measure the formation of clumps of proteins in protein-based pharmaceuticals.   view more (2008-07-24)

Yeast model shows promise as Alzheimer's test
A century ago this month, German psychiatrist Alois Alzheimer formally described characteristics of the neurodegenerative disease which ultimately came to bear his name.   view more (2006-11-20)

Proteasome activator enhances survival of Huntington's disease neuronal model cells
To function, each living cell needs both to build new and to degrade old or damaged proteins. To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins.   view more (2007-02-28)

Discoveries should aid research into cause of ALS
Two teams of researchers at Northwestern University have found a novel pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) at the molecular level.   view more (2006-04-26)

Brittle prions are more infectious
Brittleness is often seen as a sign of fragility. But in the case of infectious proteins called prions, brittleness makes for a tougher, more menacing pathogen.   view more (2006-06-29)

New research points toward mechanism of age-onset toxicity of Alzheimer's protein
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life, raising the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form.   view more (2006-08-11)

Scientists discover age-regulated cellular activities that protect against protein aggregation
Alzheimer's disease now strikes more than one in 30 Americans, and about half the population that lives past 85 acquires Alzheimer's.   view more (2006-08-14)

New studies link the environment to Parkinson's disease
The Parkinson's Institute today announced that new findings concerning the role of environmental factors in the development of Parkinson's disease will be reported at Asilomar (Pacific Grove, CA) as part of the final meeting of the Collaborative Centers for Parkinson's Disease Environmental... view more (2007-04-06)

Preserved in crystal
Scientists at the Weizmann Institute of Science recently discovered a new source of well-preserved ancient DNA in fossil bones.   view more (2006-02-03)

Vaccine thwarts the tangles of Alzheimer's
A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease.   view more (2007-08-22)

Red, red wine: How it fights Alzheimer's
Scientists call it the "French paradox" - a society that, despite consuming food high in cholesterol and saturated fats, has long had low death rates from heart disease.   view more (2008-11-21)

A protein sequence associated with Huntington's disease may become life-saving vaccine component
On June 10, 2008 the scientific journal "Vaccine" published a paper by the Massachusetts based biotech company Cure Lab, Inc., demonstrating that a protein sequence important in neurodegenerative Huntington's disease can be safely used as a new generation of vaccine adjuvants.   view more (2008-06-11)

Scientists design simple dipstick test for cocaine, other drugs
Researchers at the University of Illinois at Urbana-Champaign have developed a simple "dipstick" test for detecting cocaine and other drugs in saliva, urine or blood serum.   view more (2006-11-14)

Physics and biology team up to tackle protein folding debate
A team of researchers from EPFL, (Ecole Polytechnique Fédérale de Lausanne), the University of Lausanne, Northwestern University and Tel Aviv University bring biology and statistical physics together to answer the question of how molecular chaperones fold, unfold and pull proteins... view more (2006-04-04)

Study implicates defective synapse generator in onset of Alzheimer's
A new UCLA/Veterans Affairs study implicates defects in the machinery that creates connections between brain cells as responsible for the onset of Alzheimer disease.   view more (2006-01-27)

A Sweet Solution to Alzheimer's Disease?
Certain variants of a simple sugar ameliorate Alzheimer's-like disease in mice, according to a new study by Canadian researchers.   view more (2006-06-14)

Microbes at work cleaning up the environment
It may sound counterintuitive to use a microbial protein to improve water quality.   view more (2007-06-18)

'Intrabody' can mop up mutant protein in Huntington's disease model
Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the... view more (2008-05-27)

Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
New research from the University of North Carolina at Chapel Hill School of Medicine points to the possible molecular origin of at least nine human diseases of nervous system degeneration.   view more (2005-09-26)

Waste-powered pilot plant launched to recycle rubbish into concrete
Engineers at the University of East London are developing new eco-friendly processes to turn waste materials including incinerator bottom ash, dredge sludge and sewage into high-performance lightweight aggregates for the building industry. Working with ENTRUST registered environmental consultants... view more (2002-08-27)

Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys
Implanting dopamine generators (dopaminergics) in brain cells has produced improvement in the symptoms in Parkinson's, according to the results of tests carried out with monkeys by the Navarra University Hospital, led by Dr María Rosario Luquin Piudo, neurologist at the Hospital and at the... view more (2007-05-17)

Penn study finds way to prevent protein clumping characteristic of Parkinson's disease
Researchers at the University of Pennsylvania School of Medicine have identified a protein from a most unlikely source -- baker's yeast -- that might protect against Parkinson's disease.   view more (2008-08-15)
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