Protein Folding Current Events | Protein Folding News | 2
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Hydrogen bonds shown to play 'conserved' role in protein folding
By changing individual atoms in key places in proteins, Duke University chemists have found new evidence for the importance of comparatively weak "hydrogen bonds" in enabling stringlike proteins to fold into the maximally stable shape they need to assume their roles as biological workhorses. view more (2006-02-13)
Computer simulations point to key molecular basis of cystic fibrosis
Researchers from the University of North Carolina at Chapel Hill have identified a key molecular mechanism that may account for the development of cystic fibrosis, which about 1 in 3000 children are born with in the US every year. view more (2008-03-03)
A clue to core problem of neurodegenerative disease and cell death
Misfolded and damaged proteins are common to all human neurodegenerative diseases. Clumps of these aggregated proteins destroy neurons within the brain and cause disease. view more (2006-02-10)
UT-ORNL governor's chair unlocks secrets of protein folding
A team led by biophysicist Jeremy Smith of the University of Tennessee and Oak Ridge National Laboratory (ORNL) has taken a significant step toward unraveling the mystery of how proteins fold into unique, three-dimensional shapes. view more (2007-09-18)
New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. "Our team has defined a second prion protein called 'Shadoo', that exists in addition to the well-known prion protein called 'PrP' " said Professor David Westaway, director of the Centre for Prions and Protein Folding Diseases... view more... (2007-08-17)
NYU scientists begin second phase of project to better understand disease
A team of researchers at New York University's Center for Comparative Functional Genomics are embarking on the second phase of a collaborative research undertaking to predict structures of key proteins, which in turn shed light on their roles in diseases and offer pathways for cures. view more (2006-06-28)
University of Kent signs licensing deal with Delta Biotechnology Limited
The University of Kent has recently concluded negotiations with Delta Biotechnology - a company with more than twenty years experience in the expression of heterologous proteins - to allow licensing of the technology covered by the University's patent process for increasing the production of disulphide bonded recombinant proteins from the baker's... view more... (2004-02-05)
Protein pulling -- Learning how proteins fold by pulling them apart
Rice University physicists have unveiled an innovative way of finding out how proteins get their shape based on how they unfold when pulled apart. view more (2007-07-20)
Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's
Researchers at the Burnham Institute for Medical Research have discovered a mechanistic link between cellular stress caused by free radicals and accumulation of misfolded proteins that lead to nerve cell injury and death in neurodegenerative disorders such as Alzheimer's and Parkinson's Disease. view more (2006-05-25)
First high-res 3D structures of mammalian HSP90 protein solved
Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. view more (2007-10-15)
Scientists learn to predict protein-stabilizing ability of small molecules
Researchers at the University of Texas Medical Branch at Galveston (UTMB) have developed a new way to predict the ability of certain small molecules to protect proteins in the cells of a wide variety of organisms living in extreme environments. view more (2005-10-10)
Overexcited neurons not good for cell health
Neurotransmitters have consequences. They initiate events that are critical to a healthy life, giving us the ability to move, to talk, to breathe, to think. But that's if the neurotransmitters are getting it right and sending proper signals downstream to muscle cells, neurons or other cells. view more (2007-12-18)
St. Jude finds mechanism for faulty protein disposal
A discovery by St. Jude Children's Research Hospital scientists offers new insights into how myeloma cells dispose of defective or excess proteins and could lead to new cancer treatments. view more (2007-12-07)
Protein simulation can be done three times as fast
Protein movement can be simulated three times as fast than had been thought possible up to now. Researchers from Groningen achieved the gain in speed by leaving out the calculations concerning hydrogen atoms. Meanwhile research groups around the world are adapting their simulation programs. view more (2002-06-24)
Animal study suggests inadequate sleep may exacerbate cellular aging in the elderly
Researchers at the University of Pennsylvania School of Medicine have shown that the unfolded protein response, which is a reaction to stress induced by sleep deprivation, is impaired in the brains of old mice. view more (2008-06-30)
Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape
In an Early Edition publication of The Proceedings of the National Academy of Sciences (PNAS) this week, the researchers demonstrate the "alpha-synuclein dance" - the switching back and forth of the protein between a bent helix and an extended helix as the surface that it is binding to changes. view more (2009-03-17)
Scientists on track for early diagnosis of neurological diseases
Possible treatments for fatal neurodegenerative diseases such as CJD, Alzheimer's, Parkinson's could result from University of Edinburgh research to find out how specific proteins cause deterioration in brain function. The scientists have discovered for the first time that protein 14-3-3 plays a key role in the development of certain brain... view more... (2003-07-01)
Computer game's high score could earn the Nobel Prize in medicine
Gamers have devoted countless years of collective brainpower to rescuing princesses or protecting the planet against alien invasions. This week researchers at the University of Washington will try to harness those finely honed skills to make medical discoveries, perhaps even finding a cure for HIV. view more (2008-05-09)
Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
New research from the University of North Carolina at Chapel Hill School of Medicine points to the possible molecular origin of at least nine human diseases of nervous system degeneration. view more (2005-09-26)
Stanford researchers make first direct observation of 3-D molecule folding in real time
All the crucial proteins in our bodies must fold into complex shapes to do their jobs. These snarled molecules grip other molecules to move them around, to speed up important chemical reactions or to grab onto our genes, turning them "on" and "off" to affect which proteins our cells make. view more (2008-02-15)
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