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Caltech researchers find tiny genetic change keeps nicotine from binding to muscle cells A tiny genetic mutation is the key to understanding why nicotine--which binds to brain receptors with such addictive potency--is virtually powerless in muscle cells that are studded with the same type of receptor. view more (2009-03-24)
Turn back, wayward axon To a growing axon, the protein RGMa is a "Wrong Way" sign, alerting it to head in another direction. As Hata et al. demonstrate in the March 9, 2009 issue of the Journal of Cell Biology, translating that signal into cellular action requires teamwork from two receptors. view more (2009-03-09)
Researchers find docking sites for glucocorticoid receptor and Hsp90 University of Oregon researchers have identified protein interactions that regulate the response of cells to steroid hormones. The discovery, they say, could lead to new ways to boost the effectiveness and reduce undesired side effects of steroid-hormone treatments and cancer drugs. view more (2006-11-21)
Ritualized submission and pseudo-copulation reduce aggression among male crayfish Pseudo-copulation-an interaction that mimics sexual copulation-is a behavior known in mammalian communities that reduces aggression and signifies social dominance, particularly among males. view more (2006-11-21)
Making bacteria make useful proteins By adapting a single protein on the surface of the bacterium Caulobacter crescentus, researchers at the University of British Columbia have turned it into a protein production factory, making useful proteins that can act as vaccines and drugs. view more (2009-09-08)
Scientists develop a new way to target Alzheimer's disease The pathological embrace between two proteins plays a key role in the development of Alzheimer's disease by triggering the formation of neuron-killing plaques of amyloid beta protein. Now a group of scientists at NYU School of Medicine have devised a way to reduce amyloid beta deposition by interfering with the deadly embrace of these proteins. view more (2006-12-05)
E. coli playing the role of cobra Moscow researchers have solved the most challenging problem: they made E. coli synthesize one of the most toxic elements of cobra's poison. It was no simpler a task than keeping a terrarium. The scientists' efforts were supported by the Russian Foundation for Basic Research and INTAS. Natural poisons have always been an attraction for researchers,... view more... (2004-05-07)
New perspectives on Finnish-Swedish research The research programme Interaction across the Gulf of Bothnia has been evaluated. The Finnish-Swedish evaluation panel stated that the programme has successfully promoted cooperation between Finnish and Swedish researchers as well as between different disciplines. According to the panel, the programme has provided new insights on everything from... view more... (2005-04-08)
New information about DNA repair mechanism could lead to better cancer drugs Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells. view more (2009-07-17)
Argonne scientists reveal interaction between supersonic fuel spray and its shock wave Shock waves are a well tested phenomenon on a large scale, but scientists at the U.S. Department of Energy's (DOE) Argonne National Laboratory and their collaborators from Wayne State University and Cornell University have made a breakthrough that reveals the interaction between shockwaves created by high-pressure supersonic fuel jets. view more (2009-03-13)
Curbing C. difficile's toxin production As if being admitted to the hospital weren't bad enough, patients, once admitted, are at higher risk of becoming infected with a "superbug" bacterium, Clostridium difficile (C. difficile). view more (2007-09-06)
CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments The DNA in the 23 pairs of chromosomes in each of the billions of cells of the human body is so tightly packed that it would measure six feet in length if stretched end to end. A genome of this size can squeeze into a cell's tiny nucleus because it is compressed into highly condensed chromatin fibers by proteins called histones. view more (2009-04-10)
Amyloid beta protein gets bum rap While too much amyloid beta protein in the brain is linked to the development of Alzheimer's disease, not enough of the protein in healthy brains can cause learning problems and forgetfulness, Saint Louis University scientists have found. view more (2009-11-10)
Scientists use nanoparticle to discover disease-causing proteins A complex molecule and snake venom may provide researchers with a more reliable method of diagnosing human diseases and developing new drugs. view more (2007-02-13)
Northeastern U researchers answer longstanding question in the field of condensed matter physics ortheastern University Physics professor Sergey V. Kravchenko along with colleagues Svetlana Anissimova (Northeastern University), A Punnoose (City College if the City University of New York), AM Finkelstein (Weizmann Institute of Science, Israel) and TM Klapwijk (Delft University of Technology, Netherlands), has published an important new paper... view more... (2007-08-07)
Protein binds whenever it can Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
The structure of a key enzyme for infectious diseases solved at ESRF A European team of scientists from the University of Dundee (UK), the Technical University of Munich (Germany) and the European Synchrotron Radiation Facility, ESRF, (France) have determined the structure of a key target enzyme for novel drug development to treat infectious diseases including malaria, tuberculosis and sexually transmitted... view more... (2003-08-12)
The shape of allergy - what makes an allergen an allergen An enduring mystery for allergy researchers has been the unpredictable distribution of allergens in plants. For example, being allergic to birch pollen can predispose a person to allergy from distantly related plant foods such as celery, apple or soy. view more (2005-01-07)
A pathway towards cures for Parkinson`s and cancer Researchers studying the Hedgehog signaling pathway have identified small molecules that could form the foundations of exciting new treatments for Parkinson's disease and certain cancers. New research published in Journal of Biology - the open access journal for exceptional research - has identified small molecules that are able to stimulate or... view more... (2002-11-01)
USC researchers uncover mechanism that allows influenza virus to evade the body's immune response Researchers at the University of Southern California (USC) have identified a critical molecular mechanism that allows the influenza virus to evade the body's immune response system. view more (2009-05-21)
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