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Making sense of the human genome: researchers characterize a crucial family of signaling proteins in the human genome
In this month's Genome Biology, Mitch Kostich and colleagues from the Schering-Plough Research Institute (NJ, USA) have identified and mapped an important group of molecules known as protein kinases. These molecules are central to the communication of information both within and between cells, in a... view more (2002-08-23)

Structure of key cancer drug target identified
Researchers from Monash's Department of Biochemistry and Molecular Biology have determined the structure of the protein JAK2 kinase, a discovery with huge implications for the design and development of new cancer drugs.   view more (2005-10-26)

Researchers report the cloning of a key group of human genes, the protein kinases
Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling... view more (2008-05-05)

Estrogen protects liver after traumatic injury
Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage.   view more (2007-04-02)

MIT researchers unravel bacteria communication pathways
MIT researchers have figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment.   view more (2008-06-13)

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
Synopsis: Two papers from Woods and colleagues describe novel roles for members of the dual specificity tyrosine phosphorylated and regulated kinase (DYRK) family. In one, DYRK1A is shown to phosphorylate a novel site in the transcription factor FKHR (a forkhead protein) regulating its nuclear... view more (2001-04-24)

UCSD study reveals the regulatory mechanism of key enzyme
Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role in memory formation, communication between... view more (2007-09-21)

All eukaryotic kinases share 1 common set of substrates
Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death.   view more (2007-08-22)

Aspirin discovery may improve cancer treatments
Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood.   view more (2007-04-06)

Stowers Institute's Hawley Lab identifies factors responsible for restart of meiotic cycle
The Stowers Institute's Hawley Lab has identified a pair of proteins that work in concert to restart the meiotic cycle of oocytes following a natural period of dormancy.   view more (2007-12-05)

The Effects of Ecstasy - It Takes Two to Tango in the Cell
Amphetamine derivatives like the life style drug Ecstasy cause the release of neurotransmitters through an ingenious interplay of cellular components: an enzyme causes two transport proteins of the same type to work in opposite directions. These new findings are in contrast to previous assumptions... view more (2005-02-21)

The structure of a key enzyme for infectious diseases solved at ESRF
A European team of scientists from the University of Dundee (UK), the Technical University of Munich (Germany) and the European Synchrotron Radiation Facility, ESRF, (France) have determined the structure of a key target enzyme for novel drug development to treat infectious diseases including... view more (2003-08-12)

Mutation database helps personalized treatment of lung cancer
A groundbreaking free tool to help oncologists choose the best therapies for patients with non-small-cell lung cancer has been launched this week by scientists at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International... view more (2008-04-25)

The meiotic histone code
Dr. Terry Orr-Weaver and colleagues (MIT & Nagasaki University School of Medicine) present the first genetic analysis of the recently identified nucleosomal histone kinase, NHK-1.   view more (2005-10-17)

Hot Paper in the Biochemical Journal
DNA DAMAGE INSIGHT An exciting new paper from the Biochemical Journal regarding the phosphorylation state of LKB1 in response to ionising radiation can be viewed online as an Immediate Publication at www.BiochemJ.org (DOI: 10.1042/BJ20021284). Researchers at the University of Dundee, the University... view more (2002-09-20)

Parkinson's mutation stunts neurons
Mutations in a key brain protein known to underlie a form of Parkinson's disease (PD) wreaks its damage by stunting the normal growth and branching of neurons, researchers have found.   view more (2006-11-27)

New cellular flaw found in some virulent breast cancers
Researchers at Dana-Farber Cancer Institute have identified a molecular interaction that triggers a particularly aggressive form of breast cancer, and suggest that attacking this target with selective drugs might improve treatment.   view more (2006-01-18)

Unique dual target specificity of kinase inhibitor key for success against cancer
Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo.   view more (2006-05-16)

Unexpected role: EGFR protects cancer cells from starving
A growth factor receptor found abundantly on the surface of cancer cells and long known to fuel cancer growth also protects tumor cells from starvation by a newly identified mechanism.   view more (2008-05-06)

Scientists uncover Ebola cell-invasion strategy
University of Texas Medical Branch at Galveston researchers have discovered a key biochemical link in the process by which the Ebola Zaire virus infects cells - a critical step to finding a way to treat the deadly disease produced by the virus.   view more (2008-09-04)

McGill researchers link enzyme to breast cancer malignancy
McGill University researchers have uncovered the crucial role played by the enzyme focal adhesion kinase (FAK) in the onset of breast cancer.   view more (2007-11-30)

Early Phase II results show bosutinib safe, effective for CML
A new drug for chronic myelogenous leukemia works for patients who have developed resistance to frontline therapy and causes fewer side effects than other medications in its class, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports at the 49th annual... view more (2007-12-11)

Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems.   view more (2006-07-19)

Stopping unwanted cell death: Implications for drug discovery
Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis.   view more (2008-04-14)

3 newly discovered ERK pathway proteins related to CagA induced disease
Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer.   view more (2008-02-25)
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