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Making sense of the human genome: researchers characterize a crucial family of signaling proteins in the human genome
In this month's Genome Biology, Mitch Kostich and colleagues from the Schering-Plough Research Institute (NJ, USA) have identified and mapped an important group of molecules known as protein kinases. These molecules are central to the communication of information both within and between cells, in a... view more (2002-08-23)

Researchers report the cloning of a key group of human genes, the protein kinases
Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling... view more (2008-05-05)

All eukaryotic kinases share 1 common set of substrates
Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death.   view more (2007-08-22)

JDRF funded research shows promise for prevention, reversal of type 1 diabetes
Researchers at the University of California, San Francisco have reported that two common cancer drugs have been used to block and reverse type 1 diabetes in mice.   view more (2008-11-19)

Yale scientists decipher 'wiring pattern' of cell signaling networks
A team of scientists at Yale University has completed the first comprehensive map of the proteins and kinase signaling network that controls how cells of higher organisms operate.   view more (2005-12-01)

Structure of key cancer drug target identified
Researchers from Monash's Department of Biochemistry and Molecular Biology have determined the structure of the protein JAK2 kinase, a discovery with huge implications for the design and development of new cancer drugs.   view more (2005-10-26)

University of Helsinki to coordinate two large EU research projects
The European Union has granted nearly 25 MEUR to two large-scale interdisciplinary research projects coordinated by the University of Helsinki. The project leaders are professor Raimo Tuominen from the UH's Faculty of Pharmacy and Academy professor Kari Alitalo from UH's Molecular and Cancer... view more (2004-08-24)

Signal protein shows promise for blocking tumor promoters in skin cells
A protein with the ironic name "Srcasm" can counteract the effects of tumor-promoting molecules in skin cells, according to new research by investigators at the University of Pennsylvania School of Medicine.   view more (2006-11-06)

UCSD study reveals the regulatory mechanism of key enzyme
Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role in memory formation, communication between... view more (2007-09-21)

New cancer drug hope
Scientists helping to develop the next generation of cancer-beating drugs say they have had a major breakthrough with their latest results.   view more (2006-10-27)

Compound reveals new link between signaling protein and cell migration
University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells.   view more (2005-09-26)

Novel enzyme inhibitor paves way for new cancer drug
Combining natural organic atoms with metal complexes, scientists at The Wistar Institute have developed a new type of enzyme inhibitor capable of blocking a biochemical pathway that plays a key role in cancer development.   view more (2008-05-16)

MIT researchers unravel bacteria communication pathways
MIT researchers have figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment.   view more (2008-06-13)

New compound unusually potent at blocking brain cancer growth
By determining how a class of compounds blocks signaling in cells, UCSF scientists have identified what is perhaps the most potent drug candidate yet against a highly lethal kind of brain tumor.   view more (2006-05-16)

New strategy rapidly identifies cancer targets
In a step toward personalized medicine, Howard Hughes Medical Institute investigator Brian J. Druker and colleagues have developed a new technique to identify previously unknown genetic mutations that can trigger cancerous growth.   view more (2006-07-17)

Aspirin discovery may improve cancer treatments
Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood.   view more (2007-04-06)

Disorderly protein brings order to cell division
The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself—a disorderly molecule that seems to have a mind of its own.   view more (2007-01-29)

Early Phase II results show bosutinib safe, effective for CML
A new drug for chronic myelogenous leukemia works for patients who have developed resistance to frontline therapy and causes fewer side effects than other medications in its class, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports at the 49th annual... view more (2007-12-11)

Emory researchers identify signaling protein for multiple myeloma
Researchers at Emory University's Winship Cancer Institute are the first to discover a mechanism that plays a critical role in the multiple myeloma cell cycle and survival.   view more (2007-09-11)

Darwin's famous finches and Venter's marine microbes
Although the Galápagos finches were to play a pivotal role in the inception of Darwin's theory of evolution through natural selection, he had no inkling of their significance when he collected them during his voyage on the HMS Beagle.   view more (2007-03-14)

Energy management in cells may hold key to cancer defense
In an ongoing effort to fight disease by manipulating energy regulation of cells, a collaborative study led by Dartmouth Medical School (DMS) has demonstrated that cells lacking a tumor-suppressing kinase called LKB1 can still maintain healthy energy levels when they become stressed.   view more (2005-08-22)

Global ocean sampling expedition
In three new metagenomic studies published online in the open-access journal PLoS Biology, Craig Venter and his team take advantage of the vast amount of microbial sequence data collected during their Sorcerer II Global Ocean Sampling (GOS) expedition to reveal an unprecedented level of genetic and... view more (2007-03-14)

Single protein can determine severity of toxoplasma infections
The unusual ability of the organism Toxoplasma to infect and reproduce inside almost all warm-blooded animals has led scientists to wonder about the tricks it uses so successfully to subvert the behavior of cells.   view more (2006-12-21)

RTS and Syrrx Announce Partnership
RTS Life Science International (RTS) and Syrrx announce a partnership to develop and market high throughput structural biology automation solutions. This will be known as the HTSB Factory™ and it allows the user to set-up hundreds of thousands of experiments for a target and increase the... view more (2003-05-01)

Novel anticancer strategy moves from laboratory to clinic
Researchers at Emory University have developed a novel anti-tumor compound that represents a distinct strategy: targeting one of the most important "intercept points" for cancer cells.   view more (2008-01-04)
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