Pulmonary Fibrosis Current Events | Pulmonary Fibrosis News | 7
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PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet
New phase 2 data published today in The Lancet show that the investigational oral drug PTC124 demonstrates activity in nonsense-mutation cystic fibrosis (CF). The data show that treatment with PTC124 results in statistically significant improvements in the chloride channel function of patients with nonsense-mutation CF. The study was conducted at... view more... (2008-08-21)
EARLY PROMISE FOR TREATMENT OF PULMONARY HYPERTENSION (pp 1113, 1119)
Encouraging results of a randomised trial in this week’s issue of THE LANCET suggest that the drug bosentan could play an important future role in the treatment of pulmonary hypertension. Pulmonary hypertension (raised pressure in the blood vessels supplying the lungs) causes thickening of the right ventricle of the heart and can be... view more... (2001-10-03)
CT scans show patients with severe cases of H1N1 are at risk for developing acute pulmonary emboli
Researchers utilizing computed tomography (CT) scans have found that patients with severe cases of the H1N1 virus are at risk for developing severe complications, including pulmonary emboli (PE). view more (2009-10-14)
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time. view more (2008-11-03)
Clots traveling from lower veins may not be the cause of pulmonary embolism in trauma patients
A report from a team of Massachusetts General Hospital (MGH) physicians calls into question the longstanding belief that pulmonary embolism (PE) - the life-threatening blockage of a major blood vessel in the lungs - is caused in trauma patients by a blood clot traveling from vessels deep within the legs or lower torso. view more (2009-10-20)
Rice breakthrough could prevent multiple fibrotic diseases
A scientific breakthrough at Rice University could lead to the first treatment that prevents the build-up of deadly scar tissue in a broad class of diseases that account for an estimated 45 percent of U.S. deaths each year. view more (2007-01-19)
Are blood thinners post-op killers?
New study shows that the use of powerful anticoagulants to prevent pulmonary embolism may actually lead to more deaths after surgery view more (2008-04-01)
Researchers discover cell's 'quality control' mechanism
Researchers in Japan and Canada have discovered a key component of the quality control mechanism that operates inside human cells - sometimes too well. The breakthrough has significant implications for the development of new treatments for cystic fibrosis (CF) and some other hereditary diseases, the researchers say. Their results were published... view more... (2008-07-30)
Drug controls high-altitude illness
Acetazolamide, a drug used to manage fluid retention in heart failure, controlled the serious effects of pulmonary edema, the accumulation of fluid in lung tissue from high altitude, as well as improved brain oxygenation, during a randomized, double-blind and placebo-controlled study. view more (2007-02-01)
Deficiency in the protein MBL2 linked to increased cystic fibrosis severity
Cystic fibrosis (CF), a hereditary disorder causing thick mucous production and frequent lung infections, is associated with a high mortality rate primarily due to lung failure. view more (2008-02-22)
Cystic fibrosis clinical study patients show less lung function decline
Although cystic fibrosis patients in clinical trials had more severe illness, worse lung function, a lower weight level and more respiratory infection than non-participants, their involvement in research studies resulted in less lung function decline over a 7-year period. view more (2006-01-03)
UF study sheds light on cystic fibrosis-related diabetes
A growing number of cystic fibrosis patients are battling a second, often deadly complication: a unique form of diabetes that shares characteristics of the type 1 and type 2 versions that strike many Americans. view more (2006-07-07)
Large clinical trial finds pirfenidone may help lung function in IPF patients
A large, well-controlled, multi-national clinical trial program has demonstrated the effectiveness and safety of what may become the first FDA-approved medicine for idiopathic pulmonary fibrosis, or IPF. view more (2009-05-18)
Research Matters at the Arizona Health Sciences Center (AHSC): UA Researchers Seek Safer Cystic Fibrosis Test
Researchers from The University of Arizona Colleges of Pharmacy and Medicine are teaming up to try to invent a novel non-invasive lung test for cystic fibrosis sufferers. view more (2009-09-10)
Ibuprofen associated with slower lung function decline in children with cystic fibrosis
Treatment with ibuprofen is associated with a significantly slower rate of decline in lung function in children and adolescents with cystic fibrosis, according to a new study. view more (2007-11-30)
Nuclear Medicine Approach Can Be First Choice for Excluding Pulmonary Embolism in Young Women
Young women at risk of having a pulmonary embolism-a potential life-threatening blockage in a lung artery-should first undergo a ventilation/perfusion lung scan (V/Q scan) rather than a CT (computed tomography) angiogram. view more (2007-09-10)
Drug for erectile dysfunction improves heart function in young heart-disease patients
Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia. view more (2009-11-19)
African-Americans have unique lung cancer risks from chronic obstructive pulmonary disease
Scientists at the M.D. Anderson Cancer Center have developed a risk prediction assessment for lung cancer specifically for African Americans that suggests a greater risk from chronic obstructive pulmonary disease (COPD). view more (2008-09-05)
Mountain Climbers Vulnerable To Subclinical Lung Disorder (pp 276, 303)
Three out of four recreational climbers could be at risk of a mild form of the lung disorder called high altitude pulmonary oedema, conclude authors of a study in this week's issue of THE LANCET. High altitude pulmonary oedema (HAPE) is characterised by increased pulmonary artery pressure which leads to accumulation of fluid in the lungs. Severe... view more... (2002-01-23)
Breaking the 'mucus barrier' with a new drug delivery system
Chemical engineers from Johns Hopkins University have broken the "mucus barrier," engineering the first drug-delivery particles capable of passing through human mucus - regarded by many as nearly impenetrable - and carrying medication that could treat a range of diseases. Those conditions include lung cancer, cervical cancer and cystic... view more... (2008-08-20)
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