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Sickle cell disease corrected in human models using stem cell-based gene therapy
In a study to be published in the January 2006 issue of Nature Biotechnology, researchers led by a team of scientists at Memorial Sloan-Kettering Cancer Center have devised a novel strategy that uses stem cell-based gene therapy and RNA interference to genetically reverse sickle cell disease (SCD) in human cells. view more (2005-12-29)
Dengue Virus Reveals Its Circular Secret
The first step in the transmission of mosquito-borne viruses is no mystery: it's the pesky insect's bite that allows the virus to enter its victim's bloodstream. But for some of the most dangerous insect-borne viruses, details of what happens next have been unclear. view more (2006-08-02)
Long-term memory controlled by molecular pathway at synapses
Harvard University biologists have identified a molecular pathway active in neurons that interacts with RNA to regulate the formation of long-term memory in fruit flies. view more (2006-01-13)
Scientists crack genetic secrets of human egg
The human egg's ability to transform into a new life, or into new cells that may someday save lives, is well documented. The mystery lies in the mechanics-in how a single cell can transform so nimbly. view more (2006-09-06)
Molecule does more than slice and dice RNA
A team of Howard Hughes Medical Institute (HHMI) scientists has peeled back some of the mystery of how cells are able to turn off genes selectively to control critical events of development. view more (2006-01-13)
Basic work on E. coli identifies two new keys to regulation of bacterial gene expression
The cellular process of transcription, in which the enzyme RNA polymerase constructs chains of RNA from information contained in DNA, depends upon previously underappreciated sections of both the DNA promoter region and RNA polymerase, according to work done with the bacterium E. coli. view more (2006-06-19)
Revolution in the fight against cancer & viruses
A recent scientific discovery could herald the introduction of fast, effective treatments for cancer and viruses. view more (2006-05-26)
RNA splicing occurs in nerve-cell dendrites
Researchers at the University of Pennsylvania School of Medicine have discovered that nerve-cell dendrites have the capacity to splice messenger RNA (pre-mRNA), a process once believed to only take place in the nucleus of cells. view more (2005-11-08)
UC Riverside Researchers Discover Model Organism For Studying Viruses that Affect Humans
Researchers at the University of California, Riverside have discovered that a simple worm, called C. elegans, makes an excellent experimental host for studying some of the most virulent viruses that infect humans. view more (2005-08-18)
Cutting calories slightly can reduce aging damage
A lifelong habit of trimming just a few calories from the daily diet can do more than slim the waistline-a new study shows it may help lessen the effects of aging. view more (2006-05-09)
Molecular 'signature' protects cells from viruses
Every cell constantly produces a whole arsenal of proteins. The instruction what is to be built comes from the cell nucleus: this is where the DNA is stored, the heredity molecule in which, so to speak, the construction blueprints for all cellular proteins are stored. view more (2006-10-13)
Mouse study reveals new clues about virulence of 1918 influenza virus
The first comprehensive analysis of an animal's immune response to the 1918 influenza virus provides new insights into the killer flu, report federally supported scientists in an article appearing online today in the journal Nature. view more (2006-09-29)
Scientists unlock more secrets of HIV and SARS
UK scientists have cracked one of the key biological processes used by viruses such as HIV and SARS when they replicate. view more (2006-05-11)
UCR-led study identifies crucial mechanism involved in immune response against viruses
A research team led by UC Riverside scientists has shown that the common fruit fly can serve as an excellent model for studying the immunity animals are born with for fighting viral infections. view more (2006-03-24)
Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
A molecular "off" switch packaged in a tiny sphere penetrates deeply into ovarian cancer tumor cells, stifling a troublesome protein and drastically reducing the size of tumors. view more (2006-08-15)
Immune system response to viral DNA is unique
The human body has a unique immune system response to foreign DNA, suggesting that DNA viruses and RNA viruses are detected by different mechanisms. view more (2006-01-25)
Researchers discover new form of cancer gene regulation
The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer. view more (2005-11-08)
Gold nanoparticles could improve antisense cancer drugs
In the fight against cancer, antisense drugs, which prevent genes from producing harmful proteins such as those that cause cancer, have the promise to be more effective than conventional drugs, but the pace of development of these new drugs has been slow. view more (2006-05-19)
Penn study finds a new role for RNA in human immune response
Researchers at the University of Pennsylvania School of Medicine have published the first study to test the role of RNA chemical modifications on immunity. view more (2005-08-24)
Stanford scientist to discuss new approach to treating hepatitis C virus
Last year Peter Sarnow, PhD, professor of microbiology and immunology at the Stanford University School of Medicine, identified a previously unknown mechanism that the hepatitis C virus uses to replicate, yielding a promising new approach to combating the disease-causing virus. view more (2006-04-06)
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