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First-ever genomic test predicts which lung cancer patients need chemotherapy to live
Duke University Medical Center scientists have developed the first-ever genomic test to predict which patients with early-stage lung cancer will need chemotherapy to live and which patients can avoid the toxic regimen of drugs. view more (2006-08-10)
Defusing dangerous mutations
Mutations in genes are the basis of evolution, so we owe our existence to them. Most mutations are harmful, however, because they cause cells to build defective proteins. view more (2005-10-07)
New hypothesis for origin of life proposed
Life may have begun in the protected spaces inside of layers of the mineral mica, in ancient oceans, according to a new hypothesis. view more (2007-12-05)
The long and the short of it: Expanding small RNA biology in mammals
In independent studies, Drs. Haifan Lin (Duke University) and Toshiaki Watanabe (Kyoto University) and colleagues report on their identification of novel small RNAs in the mouse germline. view more (2006-06-09)
Scientists discover role for dueling RNAs
Researchers have found that a class of RNA molecules, previously thought to have no function, may in fact protect sex cells from self-destructing. view more (2006-11-17)
Rules to Target RNA Are Focus of Research
Once described as DNA's less-famous chemical cousin, RNA, or ribonucleic acid, recently has moved to center stage. view more (2005-12-19)
Towards a unified model of transcription termination
Dr. David Bentley (University of Colorado School of Medicine) and colleagues have developed a new, unified model for transcription termination by RNA Poymerase II. view more (2006-04-07)
RNA map provides first comprehensive understanding of alternative splicing
It's biology's version of the director's cut. In much the same way that numerous films could be stitched together from a single reel of raw footage, a molecular process called alternative splicing enables a single gene to produce multiple proteins. view more (2006-11-10)
New biomarkers for lupus found
A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease. view more (2006-11-13)
Fox Chase study sheds light on cancer susceptibility and disease involving bone-marrow failure
Defective protein production can occur in cells even when the genes controlling those proteins are normal. view more (2006-05-12)
Researchers Identify Human DNA on the Fast Track
Since completing the sequencing of the chimpanzee genome last year, geneticists have spent many hours comparing human DNA sequences to those of our closest evolutionary relative, looking for the differences that distinguish the two species. view more (2006-08-17)
New small RNAs found
Dr. Kathleen Collins and a graduate researcher in her lab at UC Berkeley have identified a second RNAi pathway in Tetrahymena thermophilia - introducing a heretofore unprecedented layer of complexity to small RNA biology in unicellular organisms. view more (2005-12-16)
Biologists probe the machinery of cellular protein factories
Proteins of all sizes and shapes do most of the work in living cells, and the DNA sequences in genes spell out the instructions for making those proteins. view more (2006-09-14)
Regulating the Nuclear Architecture of the Cell
An organelle called the nucleolus resides deep within the cell nucleus and performs one of the cell's most critical functions: it manufactures ribosomes, the molecular machines that convert the genetic information carried by messenger RNA into proteins that do the work of life. view more (2006-12-11)
Evolutionary 'battle scars' identify enhanced anti-viral activity
Rapid evolution of a protein produced by an immunity gene is associated with increased antiviral activity in humans, a finding that suggests evolutionary biology and virology together can accelerate the discovery of viral-defense mechanisms, according to researchers at Fred Hutchinson Cancer Research Center. view more (2008-01-25)
Gene silencing directs muscle-derived stem cells to become bone-forming cells
Using a relatively new technology called RNA interference to turn off genes that regulate cell differentiation, University of Pittsburgh researchers have demonstrated they can increase the propensity of muscle-derived stem cells (MDSCs) to become bone-forming cells. view more (2006-06-02)
Novel experiment documents evolution of genome in near-real time
A team led by bioengineering researchers at UC San Diego report in the November issue of Nature Genetics rapid evolutionary changes in a bacterial genome, observed in near-real time over a few days. view more (2006-11-06)
Mayo researchers discover HIV dependence on a human protein
Mayo Clinic virologists have discovered that a specific human protein is essential for HIV to integrate into the human genome. view more (2006-09-08)
RNA enzyme structure offers a glimpse into the origins of life
Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction required to make new RNA molecules. view more (2007-03-16)
Cold Spring Harbor Scientists Are Part of Consortium That Sequences Platypus Genome, Unlocking Secrets of Evolution
By any account, the platypus is an odd creature. It's got a broad, rubbery bill that brings to mind a duck-.but it swims more like a beaver-.yet it lays eggs and can inject poisonous venom, like a reptile. view more (2008-05-09)
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