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Evolutionary battle scars' identify enhanced antiviral activity
Rapid evolution of a protein produced by an immunity gene is associated with increased antiviral activity in humans, a finding that suggests evolutionary biology and virology together can accelerate the discovery of viral-defense mechanisms. view more (2008-01-25)
Chopped up proteins trigger autoimmunity
Dutch biochemist Geurt Schilders has mapped several proteins that can regulate the activity of the human exosome and which play a role in the degradation of RNA molecules. view more (2008-01-25)
Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
The use of targeted nanoparticles offers promising techniques for cancer treatment. Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies. view more (2007-05-21)
Textbook explanation of mRNA translation may need rethinking
Our understanding of how messenger RNAs are translated into proteins is challenged by new research published today in the Open Access journal Journal of Biology. view more (2005-06-27)
Mutation improves memory, may lead to memory-enhancing pill
A mind-altering mutation in mice results in an enhanced long-term memory, researchers report in the April 6, 2007 issue of the journal Cell, published by Cell Press. These findings point to a potential target for the development of a drug to treat memory loss, according to the researchers. view more (2007-04-06)
A brave new "old world" of RNA
A new function for RNA, which further elucidates how genes are expressed and regulated, is described on the 25th of November issue of the journal Nature. view more (2004-11-22)
CSHL shows correcting rna splicing may help treat spinal muscular atrophy
RNA splicing antisense technology studied at Cold Spring Harbor Laboratory (CSHL) effectively corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients, and is now ready to be tested in mouse models. view more (2007-03-13)
Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription
The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems. However, do nucleic acids possess other attributes that contribute to their biological functions? view more (2007-03-14)
New genomic tests guide choice of chemotherapy in cancer patients
Scientists at Duke University's Institute for Genome Sciences & Policy have developed a panel of genomic tests that analyzes the unique molecular traits of a cancerous tumor and determines which chemotherapy will most aggressively attack that patient's cancer. view more (2006-10-23)
UGA scientists engineer root-knot nematode resistance
University of Georgia professor Richard Hussey has spent 20 years studying a worm-shaped parasite too small to see without a microscope. view more (2006-09-27)
Body's anti-HIV drug explained
Humans have a built-in weapon against HIV, but until recently no one knew how to unlock its potential. view more (2008-10-13)
Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. view more (2006-12-08)
Mayo Clinic study explores link between nanoparticles and kidney stones
Researchers at Mayo Clinic have successfully isolated nanoparticles from human kidney stones in cell cultures and have isolated proteins, RNA and DNA that appear to be associated with nanoparticles. view more (2006-12-20)
New genetic marker characterizes aggressiveness of cancer cells
Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression. view more (2007-06-26)
Gene silencing technique offers new strategy for treating, curing disease
A new technique aimed at directly controlling the expression of genes by turning them on or off at the DNA level could lead to drugs for the treatment or cure of many diseases, say researchers at UT Southwestern Medical Center. view more (2005-08-01)
Master switches found for adult blood stem cells
Johns Hopkins Kimmel Cancer Center scientists have found a set of "master switches" that keep adult blood-forming stem cells in their primitive state. view more (2007-02-12)
HIV measurement appears to be less reliable than thought in predicting loss of CD4 cells
Preliminary research indicates that the initial HIV RNA level in untreated HIV-infected patients appears to have little value in predicting the rate of CD4 cell count decrease. view more (2006-09-27)
Scientists to assess effects of multiple copies of genes on disease risk
Scientists at Washington University School of Medicine in St. Louis and the biotech firm Nimblegen Systems Inc. have successfully tested a technique for identifying newly recognized DNA variations that may influence disease risk. view more (2007-01-31)
Loss of a universal tRNA feature reported
Scientists at the Virginia Bioinformatics Institute (VBI) report in the Journal of Bacteriology that two alphaproteobacteria lack the universal extra guanylate nucleotide typically found in the transfer RNA molecule tRNAHis. tRNAs are the molecules responsible for decoding sequence information specified by messenger RNA molecules, information... view more... (2007-02-08)
RSRF-Funded Research Links Rett Syndrome to Mitochondrial Gene
New research from the lab of Adrian Bird, a molecular geneticist at the University of Edinburgh, Scotland, reveals that abnormally high levels of a protein called Uqcrc1 in the brains of mouse models of Rett Syndrome cause mitochondria—-the cells' powerhouses—to work overtime. view more (2006-06-26)
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