Rapamycin Current Events | Rapamycin News
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Pharmaceutical market fails pregnant women; and more
In a clinical trial published this week in PLoS Medicine, Charles Sawyers and colleagues looked at the safety of a drug called rapamycin in a selected group of patients who were undergoingsurgery after recurrence of glioblastoma (a highly malignant tumor of the brain). view more (2008-01-22)
New Insights into the Mechanisms of Rapamycin
Rapamycin is a new drug which is being used for preventing organ rejection in kidney transplant patients. Since it suppresses the immune response and has a strong cell killing effect, it is a highly interesting substance for potential use in other disease areas such as cancer, autoimmune diseases, and diabetes mellitus. A recent publication of the... view more... (2004-04-07)
Transplant drug stimulates immune memory
Rapamycin, a drug given to transplant recipients to suppress their immune systems, has a paradoxical effect on cells responsible for immune memory, scientists at the Emory Vaccine Center have discovered. view more (2009-06-22)
Value of stent-coating drugs questioned
Patients admitted to the hospital with acute coronary syndromes (ACS) are often treated with a catheter-based procedure known as percutaneous coronary intervention (PCI), during which a stent is inserted into an occluded or narrowed coronary artery to restore blood flow to and from the heart. view more (2007-03-27)
Drug's epilepsy-prevention effect may be widely applicable
A drug with potential to prevent epilepsy caused by a genetic condition may also help prevent more common forms of epilepsy caused by brain injury. view more (2009-06-02)
Preclinical study suggests organ-transplant drug may aid in lupus fight
A compound related to a drug used in humans to prevent organ-transplant rejection attacks a key biochemical process in the faulty immune cells of lupus-prone mice, suggesting a possible new approach to combating the disease, UT Southwestern Medical Center researchers have found. view more (2007-08-16)
Cancer therapy: A role for MAPK inhibitors combined with mTORC1 inhibitors
Nearly a decade ago, while it was being tested as an immunosuppressive agent to prevent organ rejection in transplant patients, the drug rapamycin was also discovered to have anti-tumor properties. Since then, several rapamycin analogs known as mTOR (mammalian target of rapamycin) inhibitors have been tested in clinical trials for the treatment of... view more... (2008-08-22)
Rutgers Research Tackles Childhood Epilepsy
Rutgers researchers have discovered a potential new way to treat childhood epilepsy using a widely available therapeutic drug. view more (2009-06-10)
Scientists discover that widely available drug also helps fight kidney disease
A widely available drug may be effective in treating kidney disease, report scientists at the University of California, Santa Barbara. view more (2006-03-21)
Drug reverses mental retardation caused by genetic disorder
UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). view more (2008-06-23)
Scientists encourage cells to make a meal of Huntington's disease
Scientists have developed a novel strategy for tackling neurodegenerative diseases such as Huntington's disease: encouraging an individual's own cells to "eat" the malformed proteins that lead to the disease. view more (2007-05-08)
Rapamycin shown to inhibit angiogenesis
Scientists have long known that the blood vessels of tumors differ markedly from normal blood vessels. Now, a research team led by scientists at Beth Israel Deaconess Medical Center (BIDMC) has identified a signaling pathway which, when activated, transforms otherwise healthy blood vessels into the leaky, misshapen vasculature that characterizes... view more... (2006-08-15)
MDC researchers unravel key mechanism in pathogenesis of osteoporosis
Osteoporosis, or bone loss, is a disease that is most common in the elderly population, affecting women more often than men. view more (2009-05-15)
Chemical genomic screening identifies novel therapeutic strategies for cancer
A sophisticated new chemical genetic screening strategy that serves as a tool for identifying anticancer compounds may significantly enhance the drug discovery process. view more (2006-09-29)
New investigational treatment for bladder cancer, identified with Columbia-developed research model
A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer. view more (2009-03-13)
TB breakthrough could lead to stronger vaccine
A breakthrough strategy to improve the effectiveness of the only tuberculosis vaccine approved for humans provided superior protection against the deadly disease in a pre-clinical test, report scientists at The University of Texas Health Science Center at Houston in Nature Medicine's Advance Online Publication March 1. view more (2009-03-04)
Pathway links inflammation, angiogenesis and breast cancer
A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells. view more (2007-08-10)
Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
In one of the most ambitious spinoffs of the human genome project, researchers at Dana-Farber Cancer Institute, Children's Hospital Boston, the Broad Institute of Harvard and MIT, and other collaborating centers have unveiled a new, systematic approach to drug discovery that matches diseases with potential treatments using a universal language... view more... (2006-09-29)
Calculating gene and protein connections in a Parkinson's disease model
Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli. Using this new method, Whitehead Institute and Massachusetts Institute of Technology scientists have analyzed alpha-synuclein toxicity to identify genes and pathways that can affect cell survival. Misfolded... view more... (2009-02-23)
Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt
Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at Washington University School of Medicine in St. Louis decided to try to fine-tune the animal models used to test new drugs. view more (2008-03-03)
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