Signal Transduction Current Events | Signal Transduction News
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Brown Researchers Make Major Signal Transduction Discovery
The chemical process known as acetylation plays a central role in cytokine receptor signal transduction - a fundamental biochemical cascade inside cells that controls the activity of antiviral and tumor-suppressing genes. view more (2007-10-05)
A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found
The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. view more (2008-10-29)
Liver fibrosis will be treated by a potential target
The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis. Liver fibrosis is the early pathological process of cirrhosis, which is considered a reversible, wound-healing response. Since no ideal drug is available for its therapy, liver fibrosis is currently considered to be a major... view more... (2007-10-17)
Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. view more (2009-06-24)
Investigating the development of mechanosensitivity
Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have gained crucial insight into how mechanosensitivity arises. view more (2009-05-26)
When intestinal bacteria go surfing
The bacterium Escherichia coli is part of the healthy human intestinal flora. However, E. coli also has pathogenic relatives that trigger diarrhea illnesses: enterohemorrhagic E.coli bacteria. During the course of an infection they infest the intestinal mucosa, causing injury in the process, in contrast to benign bacteria. view more (2009-03-19)
Prostate cancer screening creates new dilemma for men, says professor
Between 70 and 80 per cent of prostate cancer was now being diagnosed at a stage where it may be curable, a press conference at ECCO 11 - The European Cancer Conference in Lisbon heard today (Wednesday, October 23, 2001). "We used to have a situation in which one of every two patients diagnosed with the disease would die. Today only three to... view more... (2001-10-23)
Cell research signals cancer hope
Scientists have moved a step closer to understanding what happens when cells receive a faulty signal that is known to be a cause of cancer. view more (2005-02-03)
One Signal Elicits Thousands of Answers
Cell signaling mechanisms often transmit information via protein modifications, most importantly the reversible attachment of phosphate, the so-called protein phosphorylation. view more (2006-11-13)
Nanoelectronic transistor combined with biological machine could lead to better electronics
If manmade devices could be combined with biological machines, laptops and other electronic devices could get a boost in operating efficiency. view more (2009-08-11)
Researchers discover new form of cancer gene regulation
The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer. view more (2005-11-08)
Key mechanism found that promotes spread of malignant melanoma
Researchers at Northwestern University have discovered a key signaling mechanism that may promote the ability of highly aggressive malignant melanoma cells to metastasize, or spread from a primary tumor to distant sites within the body. view more (2005-11-01)
Magnetic nanoparticles navigate therapeutic genes through the body
Health professionals send genes and healthy cells on their way through the bloodstream so that they can, for example, repair tissue damage to arteries. view more (2009-03-05)
Cell signaling discovery yields heart disease clues
A pulsing heart cell is giving Oregon Health & Science University researchers insight into how it sends and receives signals, and that's providing clues into how heart disease and other disorders develop. view more (2005-09-23)
Cell signaling discovery yields heart disease clues
A pulsing heart cell is giving Oregon Health & Science University researchers insight into how it sends and receives signals, and that's providing clues into how heart disease and other disorders develop. view more (2005-09-26)
Gene Test Could Reduce Unnecessary Treatment For Women With Breast Cancer (pp 340, 362)
In this week's issue of THE LANCET, US researchers describe how gene expression profiles could determine whether or not women with breast cancer would respond to docetaxel treatment. Women who are likely to be resistant to the drug could be given alternative treatment. Chemotherapy or hormonal treatment after surgery for breast cancer is crucial... view more... (2003-07-30)
Pioneers in field of functional genomics work toward gene therapy for vision defects
"Primates and humans have three photoreceptors and can only see four basic colors, red, green, blue and yellow," says Jay Neitz, Ph.D. "Birds, fish and reptiles have four photoreceptors, allowing them to see things we cannot. They must see an entire dimension of color, including ultraviolet, infrared and all the combinations... view more... (2006-12-12)
Algae understand the language of bacteria
It has hitherto not been known that higher organisms, such as green algae, can communicate with bacteria. But Debra Milton, associate professor at Ume'å University in Sweden, shows in the recent issue of the prominent journal Science that bacteria attract green algae with the aid of signal molecules. Surfaces under water are rapidly... view more... (2002-11-12)
A molecular basis for selective therapeutic intervention in Alzheimer's disease
Alzheimer's disease, a complex neurological disorder, has as one of its hallmarks the presence of senile plaques in the brains of affected individuals. view more (2005-10-07)
Bright autumn colouration in trees - a warning signal to insects?
Most deciduous trees change colour in autumn. However, both within and between species, there is considerable variation both in the timing and magnitude of autumn colour change. Hamilton and Brown recently proposed a hypothesis to explain this phenomenon. Their idea was that the bright autumn colouration in trees is a warning signal to insects... view more... (2003-09-17)
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