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Signaling Pathway Current Events | Signaling Pathway News
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Anti-tumor effects are enhanced by inhibiting 2 pathways rather than 1 Two independent research groups have found that simultaneous inhibition of two signaling pathways resulted in substantially enhanced antitumor effects in mouse models of prostate and breast cancer. In an accompany commentary, Steven Grant, at Virginia Commonwealth University Health Science Center,... view more (2008-08-22)
Penn researchers find key developmental pathway activates lung stem cells Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or... view more (2008-06-18)
Role identified for glaucoma gene and related signaling pathway Researchers have found that a gene and a related signaling pathway play a role in the development of glaucoma, which is a common cause of visual impairment and blindness worldwide. view more (2008-02-15)
Breast cancer treatment resistance linked to signaling pathway Activation of the Src signaling pathway may cause resistance to standard medical treatment in some patients with breast cancer, and inhibition of this pathway holds the potential to overcome that resistance, according to data presented here at the American Association for Cancer Research Molecular... view more (2008-09-23)
Embryonic patterning makes the feathers fly How the chicken got its feathers in the right place is not a Rudyard Kipling "Just So" story, but an illustration of how simple causes can stack up into complicated results. For a chicken, it's the difference between having feathers arranged in spots or stripes. For biologists at the... view more (2006-12-11)
Insulin signaling and amphetamines Abuse of psychostimulants such as amphetamine remains a serious public health concern. Amphetamines mediate their behavioral effects by stimulating dopaminergic signaling throughout reward circuits of the brain. view more (2007-10-16)
Rare mutation causes early heart disease and metabolic syndrome Yale School of Medicine researchers have identified a rare defect in a single gene that poses a substantial risk for metabolic syndrome and early heart disease, the leading cause of death worldwide. view more (2007-03-02)
Researchers identify protein pathway involved in Parkinson disease development Scientists have found a novel signaling pathway in cells that is altered by genetic mutations recently identified in Parkinson disease development. view more (2007-06-19)
Researchers report the cloning of a key group of human genes, the protein kinases Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling... view more (2008-05-05)
A pathway towards cures for Parkinson`s and cancer Researchers studying the Hedgehog signaling pathway have identified small molecules that could form the foundations of exciting new treatments for Parkinson's disease and certain cancers. New research published in Journal of Biology - the open access journal for exceptional research - has... view more (2002-11-01)
Endosome-mediated signaling in plants In a paper that will be published online in advance of its July 1st publication date, Drs. Niko Geldner, Joanne Chory and colleagues (The Salk Institute and HHMI) demonstrate that endosomes can function as signaling platforms in plants, as well as in animals. view more (2007-06-19)
Immunity in social amoeba suggests ancient beginnings Finding an immune system in the social amoeba (Dictyostelium discoideum) is not only surprising but it also may prove a clue as to what is necessary for an organism to become multicellular, said the Baylor College of Medicine researcher who led the research that appears today in the journal Science. view more (2007-08-03)
Wnt signalling protein Dishevelled acts in the nucleus, not just in the cytoplasm Researchers have identified that Dishevelled doesn't only function in the cytoplasm and at the cell membrane - it must also pass into the nucleus. A study published today in Journal of Biology reveals that Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, has to be localised in... view more (2005-02-11)
Einstein researchers discover gene mutations linked to longer lifespans Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. view more (2008-03-05)
BioImage A/S Signs Research Agreement with Organon BioImage A/S announced today, that it has signed a research agreement with Organon. The agreement outlines the use of BioImage's Redistribution® assays for pathway profiling of selected lead compounds, produced by Organon's discovery projects at its research and development facilities in Oss,... view more (2004-09-07)
Cancer therapy: A role for MAPK inhibitors combined with mTORC1 inhibitors Nearly a decade ago, while it was being tested as an immunosuppressive agent to prevent organ rejection in transplant patients, the drug rapamycin was also discovered to have anti-tumor properties. Since then, several rapamycin analogs known as mTOR (mammalian target of rapamycin) inhibitors have... view more (2008-08-22)
Insects and mammals share common fat-building pathway, study suggests When it comes to gaining fat, insects and mammals may have something in common, researchers report in the Jan. 11, 2006, Cell Metabolism. view more (2006-01-11)
Certain anticancer agents could be harmful to patients with heart disease A set of promising new anticancer agents could have unforeseen risks in individuals with heart disease, suggests research at Washington University School of Medicine in St. Louis. view more (2008-06-24)
Lithium and bone healing Researchers have described a novel molecular pathway that may have a critical role in bone healing and have suggested that lithium, which affects this pathway, has the potential to improve fracture healing. view more (2007-07-31)
Proteins that stop a major signaling pathway can also generate new proteins Duke University Medical Center researchers have recently discovered that a crucial communications pathway in cells not only stops cells from making proteins, it also makes them go. view more (2008-04-25)
Brain study may lead to improved epilepsy treatments Using a rodent model of epilepsy, researchers found one of the body's own neurotransmitters released during seizures, glutamate, turns on a signaling pathway in the brain that increases production of a protein that could reduce medication entry into the brain. view more (2008-04-15)
Gene discovery may shed light on kidney disease In a finding that may have broader implications for understanding kidney disorders, genetics researchers at The Children's Hospital of Philadelphia have identified a second gene that gives rise to Alagille syndrome, a genetic developmental disease that affects multiple organs. view more (2006-08-01)
Developing cancer treatments directed at critical developmental pathway Researchers from the University of Pennsylvania School of Medicine and colleagues discovered that the Notch signaling pathway, which determines the development of many cell types, and is also implicated in some cancers, is not universally essential for the maintenance of stem cells. view more (2008-04-11)
Study of nutrients' effects on brain provides insight into appetite regulation A cell-signaling pathway in the brain that is linked to the development of cancer and diabetes is also a key part of networks that regulate food intake, say University of Cincinnati (UC) researchers. view more (2006-05-12)
Penn researchers discover initial steps in the development of taste Of the five senses, taste is one of the least understood, but now researchers at the University of Pennsylvania School of Medicine have come one step closer to understanding how the sense of taste develops. view more (2006-12-06)
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