Signaling Pathway Current Events | Signaling Pathway News | 10
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One Signal Elicits Thousands of Answers
Cell signaling mechanisms often transmit information via protein modifications, most importantly the reversible attachment of phosphate, the so-called protein phosphorylation. view more (2006-11-13)
Mutations point the way to new leukemia drugs
New research indicates that drugs that target a cell growth pathway known as the JAK-STAT pathway are likely to be effective against certain chronic leukemias. view more (2006-07-18)
Oregon researchers discover a mechanism leading to cleft palate
By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries. view more (2008-02-12)
An unexpected link between coronavirus replication and protein secretion in infected cells
Coronavirus replication is critically linked to two factors within the early secretory pathway, according to new findings by a team of Dutch researchers that are published June 13th in the open-access journal PLoS Pathogens. view more (2008-06-13)
Cocaine-induced synaptic plasticity linked to persistent addictive behaviors
The persistent nature of addiction is its most devastating feature. Understanding the mechanism underlying this phenomenon is the key for designing efficient therapy. Two separate studies published by Cell Press is the August 14 issue of the journal Neuron identify specific cocaine-induced changes in dopamine (DA) neurons that play a pivotal role... view more... (2008-08-14)
New Insights Into Cardiac Aging
Investigators at Burnham Institute for Medical Research (Burnham) have found that the conserved protein d4eBP modulates cardiac aging in Drosophila (fruit flies). view more (2009-09-15)
Salk research challenges concept that motion perception is all black and white
Researchers at the Salk Institute for Biological Studies have discovered a neural circuit that is likely to play an important role in the visual perception of moving objects. view more (2006-04-20)
Controlling body size by regulating the number of cells
Why are elephants bigger than mice? The main reason is that mice have fewer cells. Research published in Journal of Biology this week uncovers a key pathway that controls the number of cells in an animal, thereby controlling its size. Ernst Hafen and his colleagues from the University of Zürich used fruit flies to investigate the role of the... view more... (2003-08-05)
KEAP1 Keeps major cancer-promoting protein at bay
A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell. view more (2009-10-12)
Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries
Every year, one million Europeans are confronted with potentially irreparable brain or spinal cord injuries resulting from traffic accidents. view more (2008-06-04)
PPAR-g agonists have potential therapeutic role in gastric carcinoma?
Recently, the potential of PPAR-γ as a target for the prevention and treatment of cancer has been widely studied. view more (2009-08-27)
Cellular 'brakes' may slow memory process in aging brains
University of Florida researchers may have discovered why some brain cells necessary for healthy memory can survive old age or disease, while similar cells hardly a hairsbreadth away die. view more (2008-12-11)
Molecular 'on/off switch' controls immune defenses against viruses
Much like flipping a light switch, the hepatitis C virus turns on human immune defenses upon entering the body but also turns off those defenses by manipulating interaction of key cellular proteins, UT Southwestern Medical Center researchers have found. view more (2006-12-26)
Scientists unlock mystery of embryonic stem cell signaling pathway
A newly discovered small molecule called IQ-1 plays a key role in preventing embryonic stem cells from differentiating into one or more specific cell types, allowing them to instead continue growing and dividing indefinitely, according to research performed by a team of scientists who have recently joined the stem-cell research efforts at the Keck... view more... (2007-03-20)
Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
Angiogenesis inhibitors that block a tumor's development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy. view more (2007-08-24)
Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team
Researchers with the University of Pennsylvania School of Veterinary Medicine have demonstrated the process by which the cancer-causing chemical dioxin attacks the cellular machinery, disrupts normal cellular function and ultimately promotes tumor progression. view more (2007-12-18)
That '4 hour erection': new discovery may help prevent a complication of priapism
For men coping with painful erections lasting for long periods of time, or priapism, new research published online in The FASEB Journal (http://www.fasebj.org) offers hope. view more (2009-10-27)
Program reduces hospitalizations and costs for nursing home residents with pneumonia
A program that includes having chest x-rays performed in the nursing home reduced the number of nursing home residents hospitalized because of pneumonia and other lower respiratory tract infections. view more (2006-06-07)
Zinc plays important role in brain circuitry
To the multitude of substances that regulate neuronal signaling in the brain and spinal cord add a new key player: zinc. By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons. view more (2006-11-27)
'Disordered" Amino Acids May Really Be There to Provide Wiggle Room for Signaling Protein
Sections of proteins previously thought to be disordered may in fact have an unexpected biological role - providing certain proteins room to move. view more (2009-05-27)
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