Signaling Pathway Current Events | Signaling Pathway News | 4
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Jefferson researchers uncover new evidence of prolactin's possible role in breast cancer
Scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the hormone prolactin in breast cancer. view more (2007-10-01)
New clue into how diet and exercise enhance longevity
The traditional prescriptions for a healthy life-sensible diet, exercise and weight control-extend life by reducing signaling through a specific pathway in the brain, according to Howard Hughes Medical Institute researchers who discovered the connection while studying long-lived mice. view more (2007-07-20)
Top notch decisions in the developing airways bring insights into lung disease
In the normal lung, the airways are lined by a balanced mixture of ciliated, secretory and neuroendocrine cells which perform functions as diverse as air humidification, detoxification, and clearance of environmental particles. view more (2009-06-09)
Manipulating Cell Receptor Alters Animal Behavior
Researchers at the University at Buffalo and the University of Pennsylvania were the first to demonstrate that two intracellular events, both stimulated by the same cell receptor, can provoke different behaviors in mammals. view more (2006-03-22)
Fate in fly sensory organ precursor cells could explain human immune disorder
Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology, researchers at Baylor College of Medicine report that a new finding about the Notch signaling pathway in sensory organ precursor cells in the fruit fly... view more... (2009-06-22)
Estrogen curbs appetite in same way as the hormone leptin
Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin. view more (2007-01-04)
Cilia: small organelles, big decisions
Johns Hopkins researchers say they have figured out how human and all animal cells tune in to a key signal, one that literally transmits the instructions that shape their final bodies. view more (2007-10-04)
Why fruits ripen and flowers die: Salk scientists discover how key plant hormone is triggered
Best known for its effects on fruit ripening and flower fading, the gaseous plant hormone ethylene shortens the shelf life of many fruits and plants by putting their physiology on fast-forward. view more (2009-02-11)
Mayo Clinic Cancer Center — individualizing treatment for multiple myeloma patients
Researchers at Mayo Clinic Cancer Center, in cooperation with industry partners, have, for the first time, identified tumor specific alterations in the cellular pathway by which the multiple myeloma drug bortezomib (Velcade) works, and they have identified nine new genetic mutations in cancer cells that should increase a patient's chance of... view more... (2006-12-11)
Looking beyond the drug receptor for clues to drug effectiveness
Antipsychotic drugs that are widely used to treat schizophrenia and other problems may not work as scientists have assumed, according to findings from Duke University Medical Center researchers that could lead to changes in how these drugs are developed and prescribed. view more (2008-08-26)
New investigational treatment for bladder cancer, identified with Columbia-developed research model
A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer. view more (2009-03-13)
Technique could speed new medulloblastoma drugs
Investigators at St. Jude Children's Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer. view more (2006-04-18)
The secret to long life
What controls lifespan? An intriguing new twist is emerging from the work of Professor Heinz Osiewacz (Frankfurt) using a short-lived fungus. He has discovered that when there is a mutation in the gene, Grisea, that controls copper uptake into cells, the fungus can live 60% longer than their normal wild-types. Why is this? Professor Osiewacz... view more... (2001-04-04)
A new relationship between brain derived neurotrophic factor and inflammatory signaling
In the October 14th edition of Science Signaling researchers at Boston University School of Medicine (BUSM), The Children's Hospital of Philadelphia/University of Pennsylvania School of Medicine and The University of Colorado Denver School of Medicine have shown that the development of epilepsy in adult rats is linked to functional changes in the... view more... (2008-10-23)
Study shows enzyme builds neurotransmitters via newly discovered pathway
The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") anandamide. view more (2006-09-12)
First functional insulin-binding protein in invertebrates
Insulin-like growth factor (IGF) signaling that helps to regulate mammals' growth, metabolism, reproduction and longevity is well documented. view more (2008-04-15)
Building memories with actin
Memories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. view more (2009-07-13)
Gene signature helps predict breast cancer prognosis
Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer. view more (2009-05-20)
Fruit flies all aglow light the way to cancer prevention
A green glow from a fruit fly is giving researchers the green light when they are on the right path in their quest to develop compounds that help prevent cancer. view more (2008-01-15)
Reversal of role for a viral protein associated with the development of lymphoma
A protein previously thought to merely hinder the activity of a key cellular protein linked to cancer cell death, now appears to mimic the cellular signaling of that protein; potentially leading to the development of lymphoma. view more (2005-08-23)
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