Signaling Pathway Current Events | Signaling Pathway News | 7
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Mouse model underestimates the critical role of Tyk2 in human immune system
A new study identifies a human Tyk2 deficiency and definitively links this molecule with multiple cytokine signals that are critical for the human immune responses. view more (2006-11-10)
Study sheds light on signaling mechanism in stem cells, cancer
UCSF scientists have illuminated a key step in a signaling pathway that helps orchestrate embryonic development. view more (2005-10-26)
FSU biologists uncover mechanisms that shape cells for better or worse
In a landmark study, biologists at Florida State University have uncovered a specific genetic and molecular mechanism that causes cell polarity - the asymmetric shape or composition critical to a cell's proper functioning. view more (2006-08-17)
Estrogen protects liver after traumatic injury
Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage. view more (2007-04-02)
Stanford researchers find culprit in aging muscles that heal poorly
Communication is critical. Garbled in, garbled out, so to (mis-)speak. Workers who get incomplete instructions produce an incomplete product, and that's exactly what happens with the stem cells in our aging muscles. view more (2007-08-10)
Liver Cancer Linked to Cellular Repair Pathway
The unchecked activity of a cell signaling pathway crucial in embryonic development and the liver's response to injury leads to liver cancer. view more (2006-03-30)
Childhood brain tumor traced to normal stem cells gone bad
An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF). view more (2008-08-12)
New target for heart failure therapy identified
A novel signaling pathway plays a significant role in the production of aldosterone, a hormone that promotes heart failure after a myocardial infarction, according to a study conducted by Thomas Jefferson University researchers. view more (2009-03-17)
Researchers discover how acid reflux leads to esophageal cancer
A particular enzyme is significantly higher in cancer cells that have been exposed to acid, leading to the overproduction of hydrogen peroxide, and offering a possible explanation for how acid reflux may lead to cancer of the esophagus, according to a recent study in the Journal of Biological Chemistry. view more (2006-08-17)
Omega-6 fats cause prostate tumors to grow twice as fast
Omega-6 fatty acids-such as those found in corn oil-caused human prostate tumors in cell culture to grow twice as quickly as tumors to which omega-6 fats had not been added, according to a study conducted at the San Francisco VA Medical Center. view more (2006-02-01)
Genetic pathway responsible for link between body clock disturbance and worsening arthritis
The genes that regulate human circadian rhythm, or 'the body clock', are significantly disturbed in individuals with arthritis. view more (2009-06-11)
Hormone helps mice 'hibernate,' survive starvation
A key hormone enables starving mice to alter their metabolism and "hibernate" to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found. view more (2007-06-06)
Researchers at Illinois explore queen bee longevity
The queen honey bee is genetically identical to the workers in her hive, but she lives 10 times longer and - unlike her sterile sisters - remains reproductively viable throughout life. view more (2007-05-09)
Possible birthplace of malignant brain tumors identified
Researchers have found that abnormal stimulation of a cellular trigger that normally regulates replenishment of brain cells in adults causes invasive tumor-like growths in mice. view more (2006-07-20)
U-M researchers reveal missing link in a heart disease pathway
University of Michigan scientists and their colleagues have helped characterize a previously unknown link in the chain of biochemical reactions implicated in some forms of heart disease. view more (2007-12-21)
Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana
Alterations in a molecular brain pathway activated by marijuana may contribute to the cognitive symptoms of schizophrenia, according to a report in the July issue of Archives of General Psychiatry, one of the JAMA/Archives journals. view more (2008-07-08)
Penn study finds pro-death proteins required to regulate healthy immune function
Researchers at the University of Pennsylvania School of Medicine have found that proteins known to promote cell death are also necessary for the maturation and proliferation of immune cells. view more (2007-08-13)
Novel enzyme inhibitor paves way for new cancer drug
Combining natural organic atoms with metal complexes, scientists at The Wistar Institute have developed a new type of enzyme inhibitor capable of blocking a biochemical pathway that plays a key role in cancer development. view more (2008-05-16)
Protein helps immune cells to divide and conquer
Researchers at the University of California, San Diego School of Medicine have identified a key protein that is required for immune cells called B lymphocytes to divide and replicate themselves. The rapid generation of large numbers of these immune cells is critical to the body's antibody defense mechanism. view more (2009-03-09)
Researchers identify new brain pathway for regulating weight and bone mass
Contrary to the prevailing view, the hormone leptin, which is critical for normal food intake and metabolism, appears to regulate bone mass and suppress appetite by acting mainly through serotonin pathways in the brain. view more (2009-09-24)
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