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Promising advance in breast cancer research
Two new drugs, when combined, killed up to 75 percent of breast cancer tumor cells in mice and suppressed the regrowth of tumors, according to researchers at the Virginia Commonwealth University Massey Cancer Center.   view more (2005-11-15)

Ruminating cows receive digestive aid
Scientists at the Institute of Grassland and Environmental Research are developing new plant breeding techniques which can improve the efficiency of cow digestion and reduce pollution at the same time. Grass isn't the easiest food to digest, and even cows appear to have difficulty doing it... view more (2004-04-01)

Study finds how organs monitor themselves during early development
How are you? In biological terms this question could involve a feedback loop that lets the body check in on itself and then act on that information   view more (2006-08-28)

Odd protein interaction guides development of olfactory system
Scientists have discovered a strange mechanism for the development of the fruit fly antennal lobe, an intricate structure that converts the chaotic stew of odors in the environment into discrete signals in the brain.    view more (2007-10-30)

Protein's potential as a regulator of brain activity discovered
UC Irvine researchers have found that a protein best known for building connections between nerve cells and muscle also plays a role in controlling brain cell activity.   view more (2006-04-21)

Study shows enzyme builds neurotransmitters via newly discovered pathway
The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") anandamide.   view more (2006-09-12)

Mouse model of osteoarthritis and more: Press release for PLoS Biology
Mouse model of osteoarthritis   view more (2004-10-12)

Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein
A protein long thought to provide only mechanical support for keeping cells and tissues from literally falling apart turns out to have much wider utility.   view more (2006-05-18)

Key to out-of-control immune response in lung injury found
Researchers at the University of Illinois at Chicago College of Medicine have discovered how a protein modulates the inflammatory response in sudden, life-threatening lung failure. The protein's previously unknown role is reported in the August issue of Nature Medicine.   view more (2007-08-17)

First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear... view more (2006-04-03)

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects
Interferon - a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors - may soon have greater therapeutic value.   view more (2005-10-03)

CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
With the genomes of hundreds of organisms now catalogued, one of the next major challenges is to identify proteins and their interactions.   view more (2006-10-05)

Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.   view more (2007-12-11)

New research points toward mechanism of age-onset toxicity of Alzheimer's protein
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life, raising the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form.   view more (2006-08-11)

Research provides clues to obesity's cause and hints of new approach for curbing appetite
Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.   view more (2006-04-10)

Biologists visualize protein interaction that may initiate viral infection
Biologists at Purdue University have taken a "snapshot" of a Velcro-like protein on a cell's surface just after it attached to the dengue virus, a linkup thought to initiate the early stages of infection.   view more (2006-02-10)

Engineered molecule amplifies body's immune response
By altering a molecule called Stat1, which is involved in cellular immune signaling, scientists have succeeded in making the molecule more responsive and thus more efficient.   view more (2005-09-29)

Research Reveals Inner Workings of Immune System "Thermostat"
When bacteria, viruses or parasites attack, immune system cells unleash the soldiers. These "hot" protein compounds kill invaders - but also trigger inflammation, which, if unchecked, can destroy tissue, induce shock and kill the host.   view more (2006-08-21)

Protein splicing upsets the DNA colinearity paradigm
Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein.   view more (2006-09-08)

New discovery may improve treatment of one of the world's leading causes of blindness
An inflammatory eye condition that is one of the world's leading causes of blindness could be treated much more effectively and easily thanks to a new discovery here.   view more (2007-10-01)

Preventing toxic side effects of inflammatory disease therapy
Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a mouse model that could help scientists develop better drugs to fight autoimmune and inflammatory disorders such as multiple sclerosis and rheumatoid arthritis.   view more (2006-02-09)

How can we know early who will benefit from tumor target therapy?
The precise tailoring of tumor target treatment for patients with cancer is an unmet challenge. The goal is to only administer treatments that have a high probability of being effective.   view more (2007-11-26)

Zinc plays important role in brain circuitry
To the multitude of substances that regulate neuronal signaling in the brain and spinal cord add a new key player: zinc. By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons.   view more (2006-11-27)

Lessons from yeast: A possible cure for Parkinson's disease?
Parkinson disease (PD) is a debilitating and lethal neurodegenerative disease, for which there is currently no cure. It is caused by the progressive loss of nerve cells that produce the chemical dopamine and is characterized by the accumulation of abnormal aggregates of a protein called alpha-syn... view more (2008-08-15)

Researchers discover a new genetic cause of Alzheimer's disease
Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp are the first to show that the quantity of amyloid protein in brain cells is a major risk factor for Alzheimer's disease.   view more (2006-04-20)
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