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Lessons from yeast: A possible cure for Parkinson's disease?
Parkinson disease (PD) is a debilitating and lethal neurodegenerative disease, for which there is currently no cure. It is caused by the progressive loss of nerve cells that produce the chemical dopamine and is characterized by the accumulation of abnormal aggregates of a protein called alpha-syn... view more (2008-08-15)

Researchers discover a new genetic cause of Alzheimer's disease
Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp are the first to show that the quantity of amyloid protein in brain cells is a major risk factor for Alzheimer's disease.   view more (2006-04-20)

Preventing toxic side effects of inflammatory disease therapy
Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a mouse model that could help scientists develop better drugs to fight autoimmune and inflammatory disorders such as multiple sclerosis and rheumatoid arthritis.   view more (2006-02-09)

New discovery may improve treatment of one of the world's leading causes of blindness
An inflammatory eye condition that is one of the world's leading causes of blindness could be treated much more effectively and easily thanks to a new discovery here.   view more (2007-10-01)

How can we know early who will benefit from tumor target therapy?
The precise tailoring of tumor target treatment for patients with cancer is an unmet challenge. The goal is to only administer treatments that have a high probability of being effective.   view more (2007-11-26)

Zinc plays important role in brain circuitry
To the multitude of substances that regulate neuronal signaling in the brain and spinal cord add a new key player: zinc. By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons.   view more (2006-11-27)

U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
Understanding the structure of proteins involved in inhibiting HIV-1 infection could help in the battle against AIDS, and University of Minnesota researchers have taken a crucial step in that direction.   view more (2008-02-21)

Can cancer drugs combine forces?
Individuals with chronic myeloid leukemia (CML) are treated first with a drug known as imatinib (Gleevec), which targets the protein known to cause the cancer (BCR-ABL).   view more (2007-08-17)

New Cancer Gene Discovered
Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears Monday in Nature's cancer journal Oncogene.   view more (2008-05-09)

New clue into how diet and exercise enhance longevity
The traditional prescriptions for a healthy life-sensible diet, exercise and weight control-extend life by reducing signaling through a specific pathway in the brain, according to Howard Hughes Medical Institute researchers who discovered the connection while studying long-lived mice.   view more (2007-07-20)

Mutation in brain cells of descendants of Abraham Lincoln suggest he suffered from movement disorder
Researchers at Johns Hopkins and the University of Minnesota have discovered a gene mutation in the descendants of Abraham Lincoln's grandparents that suggests the Civil War president himself might have also suffered from a disease that destroys nerve cells in the cerebellum- the part of the brain... view more (2006-02-03)

New target for Alzheimer's disease identified
Alzheimer's disease (AD) is an incurable disease that is increasing in prevalence and will increase even more rapidly as the Baby Boom generation enters the age of highest risk. The available AD drugs are only partially effective in some patients. New strategies are urgently needed.   view more (2008-05-07)

New path from estrogen to survival in breast cancer cells described
After years of research, scientists at The University of Texas M. D. Anderson Cancer Center are now able to explain, in exquisite molecular detail, how the estrogen hormone can help keep breast cancer cells alive.   view more (2006-09-26)

Disrupting common parasites' ability to 'talk' to each other reduces infection
One of the most common human parasites, Toxoplasma gondii, uses a hormone lifted from the plant world to decide when to increase its numbers and when to remain dormant, researchers at Washington University School of Medicine in St. Louis have found.   view more (2008-01-10)

Fragments of dinosaur protein survive in bone fossils
Proteins are tougher than we think - which is good news for scientists trying to piece together the history of evolution from fragments of ancient DNA. In this month’s (December 2000) edition of the journal, Geology, Dr Matthew Collins, of Newcastle University, England, shows how significant... view more (2000-12-18)

New findings show additional similarity between opiate and nicotine addiction
"That was good!" "Do it again." This is what the brain says when people use tobacco, as well as 'hard drugs' such as heroin.   view more (2008-02-13)

How genetic malfunction causes a form of retardation
Researchers have discovered that the genetic malfunction that causes a form of mental retardation called Noonan Syndrome (NS) produces an imbalance in the genesis of two types of cells in the developing embryonic brain.   view more (2007-04-19)

Gene's newly explained effect on height may change tumor disorder treatment
A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion, researchers at Washington University School of Medicine in St. Louis have found.   view more (2008-08-12)

T-beta-RIII joins the fight against breast cancer
Although the soluble factor TGF-beta has been shown to suppress the growth of tumor cells in the early stages of breast cancer, high levels of TGF-beta during the later stages of the disease are associated with a poor outcome.   view more (2006-12-08)

Studies link cancer, inflammatory disease
The biological processes underlying diseases such as rheumatoid arthritis and cancer are fundamentally linked, and should be linked in how they are treated with drugs, a series of MIT studies indicates.   view more (2006-04-06)

Researchers identify target for therapeutic drugs to fight most common adult brain cancer
A research team at UT Southwestern Medical Center has discovered a cell-signaling mechanism instrumental in the most common brain cancer in adults.   view more (2006-01-16)

Huntington's disease problem start early
The damaging effects of the mutated protein involved in Huntington's disease take place earlier in cell life than previously believed, said researchers from Baylor College of Medicine in Houston in a report that appears in the current edition of the journal Neuron.   view more (2008-01-10)

New study raises questions about the number of people in the UK who could be incubating vCJD
A team of UK scientists found that 3 out of 12,674 stored appendix and tonsil samples showed evidence of the prion protein associated with vCJD, but urge caution about the way these results are interpreted. The research is published this week in The Journal of Pathology. The study aimed to help... view more (2004-05-18)

Suppression of FOXO1a gene might kill resistant ARMS tumors
The loss of function of a gene called FOXO1a plays an important role in the development of the most common cancer of soft tissues in children, and restoring the function of that gene in cancer cells suppresses that cancer.   view more (2005-09-22)

New discovery may improve treatment of neurodegenerative diseases and type 2 diabetes
The discovery opens the way for new drugs to be designed to treat Parkinson's, type 2 diabetis, Alzheimer's and Creuzfeldt-Jacob disease.   view more (2005-12-15)
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