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Study offers innovative profile of enzyme that aids tumor growth
To date, understanding the roles of uncharacterized enzymes in cell physiology and pathology has remained problematic.   view more (2006-10-23)

Manipulating Cell Receptor Alters Animal Behavior
Researchers at the University at Buffalo and the University of Pennsylvania were the first to demonstrate that two intracellular events, both stimulated by the same cell receptor, can provoke different behaviors in mammals.   view more (2006-03-22)

Protein plays broader role than originally thought in neurofibromatosis
Neurofibromatosis type I is a common genetic disorder in which tumors grow along certain types of nerves and can also affect other tissues such as bone, heart, and skin.   view more (2006-08-11)

New genetic mutations found that may cause cleft lip/palate
University of Iowa researchers and collaborators have identified new genetic mutations that likely cause the common form of cleft lip and palate.   view more (2007-03-06)

Study uncovers significant functional differences of novel estrogen receptor
Because of these differences, this new estrogen receptor could become an important therapeutic target and may play a further signaling role in other estrogen target tissues, including uterus and prostate tissues.   view more (2006-06-09)

Study unveils how West Nile virus evades immune defenses, points to vaccine development
West Nile virus evades the body's immune defenses by blocking immune signaling by a protein receptor, a finding that could pave the way for a vaccine to protect against North American strains of the virus.   view more (2006-10-05)

Cytokine resistance contributes to pathology of type 2 diabetes
In a study appearing this month in the Journal of Immunology, researchers at the University of Illinois describe how an impaired anti-inflammatory response plays a role in the pathology of type 2 diabetes.   view more (2007-06-18)

Researchers uncover mechanisms of common inherited mental retardation
Researchers at UT Southwestern Medical Center are uncovering how brain cells are affected in Fragile X syndrome, the most common cause of inherited mental retardation and the most common genetic cause of autism.   view more (2008-01-09)

GABA halts stem cell production in the brain
Release of the neurotransmitter GABA by adult neuronal precursor cells that develop into neurons limits stem cell proliferation, according to a study at Yale School of Medicine in the September issue of Nature Neuroscience.   view more (2005-09-02)

Protein maintains cross talk between cells that control hair growth
Genes, it turns out, are only as active as the signals that turn them on and off. Now scientists from Rockefeller University and the Howard Hughes Institute have identified the signaling molecule that ratchets up and clamps down the activity of key genes in dermal papilla, a type of skin cell whose... view more (2008-02-15)

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses
Despite the fact that they both infect the liver, the hepatitis A and hepatitis C viruses actually have very little in common.   view more (2007-04-19)

Estrogen protects liver after traumatic injury
Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage.   view more (2007-04-02)

Keeping amyloid-and Alzheimer's-in check
Researchers have identified a protein that reins in the rogue activity of the molecules that make the amyloid-beta protein-which may prevent normal brain function in people with Alzheimer's disease.   view more (2006-04-27)

PINK1 protects from Parkinson's
Parkinson disease (PD) is a common neurodegenerative disease characterized by the selective loss of midbrain dopaminergic neurons.   view more (2007-06-19)

Looking beyond the drug receptor for clues to drug effectiveness
Antipsychotic drugs that are widely used to treat schizophrenia and other problems may not work as scientists have assumed, according to findings from Duke University Medical Center researchers that could lead to changes in how these drugs are developed and prescribed.   view more (2008-08-26)

Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
Researchers at the University of Pennsylvania School of Medicine have shown how Argos, a fruit fly protein, acts as a ¡¥decoy' receptor, binding growth factors that promote the progression of cancer.   view more (2008-05-29)

Protein holds back growth of head and neck tumors
A protein associated with the growth of head and neck tumors may be a tumor suppressor that could prevent the spread of cancer when it is expressed above normal levels.   view more (2006-02-01)

Reversal of role for a viral protein associated with the development of lymphoma
A protein previously thought to merely hinder the activity of a key cellular protein linked to cancer cell death, now appears to mimic the cellular signaling of that protein; potentially leading to the development of lymphoma.   view more (2005-08-23)

Executable biology -- Computer science sheds light on animal development
By applying the techniques of computer engineering to a mechanistic diagram describing the development of the Nematode C. elegans, a group of researchers in Switzerland has been able to tease out what laboratory experiments have not - how and when the crucial cross-talk between cellular signaling... view more (2007-05-18)

New molecular regulators of hyperthyroidism and goiter
The thyroid gland has an important role in determining how much energy the body burns. Thyroid gland functions are regulated by a hormone known as thyroid-stimulating hormone (TSH).   view more (2007-08-10)

Chemical genomic screening identifies novel therapeutic strategies for cancer
A sophisticated new chemical genetic screening strategy that serves as a tool for identifying anticancer compounds may significantly enhance the drug discovery process.   view more (2006-09-29)

A wolf in sheep's clothing: plague bacteria reveal one of their virulence tricks
The bacterium that causes the plague belongs to a virulent family of bacteria called Yersinia, a group that also includes a pathogen responsible for food poisoning.   view more (2006-09-21)

U. Iowa team identifies genes that improve survival in mice with ALS
University of Iowa researchers investigating the basic biology of cell signaling have made a discovery that may have therapeutic implications for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.   view more (2007-09-14)

New brain cells implicated in machinery of cannabinoid signaling
The brain cells called astrocytes, and not just neurons, are sensitive to the substances called cannabinoids-the active chemicals in marijuana.   view more (2008-03-27)

Yale scientists decipher 'wiring pattern' of cell signaling networks
A team of scientists at Yale University has completed the first comprehensive map of the proteins and kinase signaling network that controls how cells of higher organisms operate.   view more (2005-12-01)
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