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Protein key to control, growth of blood cells
New research sheds light on the biological events by which stem cells in the bone marrow develop into the broad variety of cells that circulate in the blood. The findings may help improve the success of bone marrow transplants and may lead to better treatments for life-threatening blood diseases.   view more (2008-08-14)

New compound unusually potent at blocking brain cancer growth
By determining how a class of compounds blocks signaling in cells, UCSF scientists have identified what is perhaps the most potent drug candidate yet against a highly lethal kind of brain tumor.   view more (2006-05-16)

Communication within the immune system:Immune synapses cannot function without ZAP-70
A familial form of severe combined immune deficiency (SCID) is caused by anomalies of an enzyme called ZAP-70. If ZAP-70 is lacking or does not work, the T-cells, which play a key role in the mechanisms of immune defense, are no longer functional. Affected children therefore catch infections as... view more (2002-10-24)

Protein transport in mitochondria revealed
The TIM23 complex, which regulates the transport of protein to the mitochondria in a cell, is much more complicated than was previously believed. This is shown by Uppsala University researcher Maria Lind in an article in the leading journal Cell.   view more (2005-03-31)

Discovery supports theory of Alzheimer's disease as form of diabetes
Insulin, it turns out, may be as important for the mind as it is for the body. Research in the last few years has raised the possibility that Alzheimer's memory loss could be due to a novel third form of diabetes.   view more (2007-09-27)

Infection-fighting protein could be key to autoimmune disease, say U-M scientists
Scientists at the University of Michigan Medical School have discovered that a protein called cryopyrin responds to invading bacteria by triggering the activation of a powerful inflammatory molecule called IL-1beta, which signals the immune system to attack pathogens and induces fever to protect... view more (2006-01-12)

Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
Schizophrenia is a developmental disorder with a large genetic component contributing to increased risk. Available antipsychotic medications treat some of the symptoms of schizophrenia, but are typically effective in only a subset of patients.   view more (2008-01-09)

Researchers uncover mechanisms leading to portal hypertension
A physician-scientist at UT Southwestern Medical Center and his research team have identified mechanisms causing a potentially deadly type of hypertension that results from liver damage-findings that could lead to its prevention.   view more (2005-09-30)

New Diagnostic Faecal Test Could Identify Colorectal Cancer (p 1917)
Authors of a research letter in this week's issue of THE LANCET describe a new technique where the detection of a specific protein in faeces could be a marker for colorectal cancer. Colorectal cancer is a common disease (causing around 500,000 deaths each year worldwide), and screening methods that... view more (2002-05-29)

Oregon researchers show how resident bacteria shape gut development
University of Oregon researchers have shown that bacteria residing in the intestine shape gut development by means of several distinct signaling mechanisms.   view more (2006-06-22)

USC researchers identify mechanism that controls activation of stem cells during hair regeneration
Researchers at the University of Southern California (USC) have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models.   view more (2008-01-17)

Researchers devise new tools to help pinpoint treatments for heart failure
Scientists studying heart cells have devised a new way to visualize and quantify the rise and fall in the activity of a key enzyme linked to heart failure, offering them a window to the inner workings of heart cells that is expected to help in the development of more effective drugs to treat heart... view more (2006-08-08)

ESC Congress 2003: C-reactive protein, an inflammatory biomarker, predicts progression of aortic valve stenosis
IMPORTANT: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology Aortic stenosis (AS) is the narrowing or obstruction of... view more (2003-08-31)

Dietary preferences and patterns may be linked to genes
The relative amount of protein, carbohydrate, and fat that people choose to eat may be influenced by genetics, according to new research.   view more (2007-06-08)

Researchers discover new way to reverse poor circulation and heal wounds
Researchers have solved a longstanding mystery about how flexing muscles "tell" nearby blood vessels that they need more blood to perform, according to a study published Feb. 15 in the journal Circulation Research.   view more (2008-02-15)

Study in Circulation provides detail on how low blood flow promotes vascular disease
Researchers have found the first direct proof that a key protein drives the clogging of arteries in two ways, and that lowering levels of it opens them up, according to study results published in the June edition of the journal Circulation.   view more (2008-06-24)

Brain cells help neighboring nerves regenerate
Researchers have uncovered a completely unexpected way that the brain repairs nerve damage, wherein cells known as astrocytes deliver a protective protein to nearby neurons.   view more (2008-05-28)

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time.   view more (2007-05-04)

Study shows how daughter is different from mother
The mother-daughter relationship can be difficult to understand. Why are the two so different? Now a Northwestern University study shows how this happens. In yeast cells, that is.   view more (2008-08-19)

New technology illuminates protein interactions in living cells
While fluorescence has long been used to tag biological molecules, a new technology developed at Yale allows researchers to use tiny fluorescent probes to rapidly detect and identify protein interactions within living cells while avoiding the biological disruption of existing methods, according to... view more (2007-11-12)

Vax and Pax: Taking turns to build an eye
Opposing ball clubs don't take the field at the same time, and neither do teams of proteins responsible for creating the eye. While one team builds the retina, in adjacent cellular turf the opponents are busy constructing the cord that carries visual signals to the brain. And these guys aren't... view more (2006-10-16)

Treatments have same target, different responses for lung cancer patients with genetic mutation
The gene mutation that identifies the lung cancer patients most likely to respond to the drug gefitinib (Iressa) is not associated with a response to the drug cetuximab (Erbitux).   view more (2005-08-17)

Technique could speed new medulloblastoma drugs
Investigators at St. Jude Children's Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer.   view more (2006-04-18)

Researchers develop mouse model of autism spectrum disorders
Howard Hughes Medical Institute researchers have genetically engineered mice that harbor the same genetic mutation found in some people with autism and Asperger syndrome.   view more (2007-09-07)

Researchers discover how acid reflux leads to esophageal cancer
A particular enzyme is significantly higher in cancer cells that have been exposed to acid, leading to the overproduction of hydrogen peroxide, and offering a possible explanation for how acid reflux may lead to cancer of the esophagus, according to a recent study in the Journal of Biological... view more (2006-08-17)
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