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Key finding in rare muscle disease
The finding is in the current issue of Annals of Neurology, a leading international neurology journal, in work led by Professor Nigel Laing and Dr Kristen Nowak of the Laboratory for Molecular Genetics at the Western Australian Institute for Medical Research (WAIMR) and done in collaboration with a number of European researchers.   view more (2007-01-18)

Gene therapy accelerates healing of damaged skeletal muscle
University of Pittsburgh School of Medicine researchers have successfully used gene therapy to accelerate muscle regeneration in experimental animals with muscle damage, suggesting this technique may be a novel and effective approach for improving skeletal muscle healing, particularly for serious sports-related injuries.   view more (2006-06-05)

Researchers identify gene associated with muscular dystrophy-related vision problems
Skeletal muscle disease and vision deficits might seem unrelated, but a frog model of muscular dystrophy shows it is not such a leap.   view more (2009-04-21)

Heart saves muscle
A heart muscle protein can replace its missing skeletal muscle counterpart to give mice with myopathy a long and active life.   view more (2009-05-26)

Scientists find the pathological prion protein in skeletal muscles of hamster with scrapie
In the May 2003 issue of EMBO reports, researchers from the German Robert Koch Institute in Berlin report finding the pathological prion protein PrPSc in a wide range of skeletal muscles after feeding hamsters with prion-infected food. PrPSc is believed to be an essential - if not the sole - constituent of the agent that causes BSE in cattle,... view more... (2003-04-10)

Muscle atrophy through thick but not thin
During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids.   view more (2009-06-08)

High-fat diet impairs muscle health before impacting function
Skeletal muscle plays a critical role in regulating blood sugar levels in the body. But few studies have comprehensively examined how obesity caused by a high-fat diet affects the health of muscle in adolescents who are pre-diabetic.   view more (2009-10-06)

Fat-generated hormone drives energetic capacity of muscle
The fat-generated hormone adiponectin plays an important role in the energetic capacity of skeletal muscle, according to a new study in the July, 2006, Cell Metabolism.   view more (2006-07-06)

Standing up to paraplegia with gene therapy
Elena Rugarli and colleagues from the National Neurological Institute in Milan have used gene therapy to save sensory and skeletal muscle nerve fibers from degeneration in mice with hereditary spastic paraplegia (HSP).   view more (2005-12-16)

CU-Boulder research team identifies stem cells that repair injured muscles
A University of Colorado at Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice, which could have important implications in the treatment of injured, diseased or aging muscle tissue in humans, including the ravages of muscular dystrophy.   view more (2009-03-06)

Resistance exercise resets the body clock
Resistance exercise may directly reset the body clocks in skeletal muscle, according to research published in Genome Biology this week. This result may partly explain how exercising early in the day helps jet-lagged bodies readjust to their new time zone. Many processes in the body vary in a 24-hour rhythm called the circadian rhythm. These... view more... (2003-09-24)

The fight against obesity -- a new insight
With obesity still on the increase, it appears that the main weapon in the fight against it - reducing energy consumption by eating less - is ineffective.   view more (2008-03-12)

Tissue regeneration operates differently than expected
Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany, in co-operation with colleagues from Martin Luther University in Halle-Wittenberg, have now shown that skeletal muscle tissue can fuse with adult stem cells, via a mechanism based on the participation of mediators which are generally involved in immune... view more... (2005-08-05)

Growth hormone treatment after weight loss surgery prevents loss of muscle mass
Growth hormone treatment for six months after weight loss surgery reduces patients' losses in lean body mass and skeletal muscle mass, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).   view more (2009-02-03)

Don't move a muscle: Evolutionary insight into myogenesis
In a paper released online ahead of its scheduled December 15th publication date, Dr. Michael Krause (NIH) and colleagues detail the transcription network that drives muscle development in the roundworm C. elegans, and make a strong argument for an evolutionarily conserved program of myogenesis in all animals.   view more (2006-12-07)

Mutation responsible for cystic fibrosis also involved in muscle atrophy
Patients with cystic fibrosis (CF) usually experience significant muscle loss, a symptom traditionally considered to be a secondary complication of the devastating genetic disease.   view more (2009-07-31)

While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers at Columbia University Medical Center have discovered that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder.   view more (2009-02-09)

Australian team reveals world-first discovery in a 'floppy baby' syndrome
In a world first, West Australian scientists have cured mice of a devastating muscle disease that causes a Floppy Baby Syndrome - a breakthrough that could ultimately help thousands of families across the globe.   view more (2009-05-26)

Researchers find level of special protein is critical to proper formation of muscles
Proper formation of the proteins that power heart and skeletal muscle seems to rely on a precise concentration of a "chaperone" protein known as UNC-45, according to a new study.   view more (2007-04-25)

MU logo News Bureau University of Missouri About the News Bureau Contact Us Home / News Releases / 2009 MU Researchers Discover Target that Could Ease Spinal Muscular Atrophy Symptoms
There is no cure for spinal muscular atrophy (SMA), a genetic disorder that causes the weakening of muscles and is the leading genetic cause of infant death, but University of Missouri researchers have discovered a new therapeutic target that improves deteriorating skeletal muscle tissue caused by SMA. The new therapy enhanced muscle strength,... view more... (2009-01-08)
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