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Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
Genetically modifying a receptor found on the neurons that produce the neurotransmitter dopamine has given California Institute of Technology (Caltech) researchers a unique glimpse into the workings of the brain's dopamine system--as well as a new target for treating diseases that result from either too much or too little of this critical... view more... (2008-10-15)
Potent urine gets the girl
Scientists at the Centre of Marine Sciences (University of the Algarve) have discovered that female tilapia fish are highly sensitive to the smell of male tilapia urine during courtship, especially a territorial male's more potent urine. As Drs. Eduardo Barata and Peter Hubbard, the project's leading scientists, state, "As compared with other... view more... (2003-03-26)
Cannabinoids produced in the human body have an anti-inflammatory effect
Endocannabinoids seem to play an important role in regulating inflammation processes. Scientists from the University of Bonn have discovered this in experiments on mice. view more (2007-06-08)
Scientists model 900 cell receptors, drug targets
In an important step toward accelerating drug discovery, researchers have created computer models of more than 900 cell receptors from a class of proteins known to be important drug targets. view more (2006-02-17)
Grabbing addiction by the tail
Canadian scientists have developed some clever molecular trickery that is helping to reduce the drug cravings of addicted rats. One of the problems in addiction is that neurons in some parts of the brain lose glutamate receptors from the cell surface, and those receptors are important for communication between neurons. view more (2005-11-28)
A new relationship between brain derived neurotrophic factor and inflammatory signaling
In the October 14th edition of Science Signaling researchers at Boston University School of Medicine (BUSM), The Children's Hospital of Philadelphia/University of Pennsylvania School of Medicine and The University of Colorado Denver School of Medicine have shown that the development of epilepsy in adult rats is linked to functional changes in the... view more... (2008-10-23)
Aging brain reduces ovulation
Dutch researcher Annelieke Franke has discovered that the aging of the brain adversely affects the fertility of female rats. The scientist suspects that her research will provide insights into fertility problems of women over the age of 30. Franke studied relatively young subfertile rats. Although the pituitary gland and ovaries of these rats... view more... (2003-10-10)
Abuse of painkillers can predispose adolescents to lifelong addiction
No child aspires to a lifetime of addiction. But their brains might. In new research to appear online in the journal Neuropsychopharmacology this week, Rockefeller University researchers reveal that adolescent brains exposed to the painkiller Oxycontin can sustain lifelong and permanent changes in their reward system - changes that increase the... view more... (2008-09-10)
Persistent pollutant may promote obesity
Tributyltin, a ubiquitous pollutant that has a potent effect on gene activity, could be promoting obesity, according to an article in the December issue of BioScience. view more (2008-12-01)
Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment
A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say. view more (2009-05-21)
Preclinical study shows chronic stress agitates ovarian cancer; reducing stress slows tumor growth
When mice with ovarian cancer are stressed, their tumors grow and spread more quickly, but that effect can be blocked using a medication commonly prescribed for heart disease. view more (2006-07-24)
UCSD study of nuclear receptors could change anti-inflammatory treatments
Several nuclear receptor proteins appear to overlap in their ability to exert anti-inflammatory effects, according to new research by scientists at the University of California, San Diego (UCSD). view more (2005-09-09)
Potential new way of treating inflammatory diseases identified
Scientists have shown for the first time that platelets, the cells needed for blood clotting, help white blood cells called neutrophils fight inflammation. view more (2007-09-14)
Scientists find a common link of bird flocks, breast milk and trust
What do flocks of birds have in common with trust, monogamy, and even breast milk? view more (2009-08-14)
Caltech researchers find tiny genetic change keeps nicotine from binding to muscle cells
A tiny genetic mutation is the key to understanding why nicotine--which binds to brain receptors with such addictive potency--is virtually powerless in muscle cells that are studded with the same type of receptor. view more (2009-03-24)
New research shows sharks use their noses and bodies to locate smells
Sharks are known to have a keen sense of smell, which in many species is critical for finding food. However, according to new research from Boston University marine biologists, sharks can not use just their noses to locate prey; they also need their skin - specifically a location called the lateral line. view more (2007-05-30)
Food restriction increases dopamine receptor levels in obese rats
A brain-imaging study of genetically obese rats conducted at the U.S. Department of Energy's Brookhaven National Laboratory provides more evidence that dopamine - a brain chemical associated with reward, pleasure, movement, and motivation - plays a role in obesity. view more (2007-10-25)
Worm's hunger response provides clue to eating disorders
In research that may have implications for studying eating disorders in humans, a worm the size of a pinhead is helping researchers at UT Southwestern Medical Center unravel the mechanisms of hunger. view more (2006-04-05)
Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
Like tuning a violin to produce strong, elegant notes, researchers at The Wistar Institute have found multiple receptors on the outside of the body's killer immune system cells which they believe can be selectively targeted to keep the cells in superb infection- and disease-fighting condition. view more (2008-12-01)
New brain cells implicated in machinery of cannabinoid signaling
The brain cells called astrocytes, and not just neurons, are sensitive to the substances called cannabinoids-the active chemicals in marijuana. view more (2008-03-27)
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