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Molecular Therapy for Spinal Muscular Atrophy Closer to Clinical Use
Spinal muscular atrophy, a neurodegenerative disorder that causes the weakening of muscles, is the leading cause of infant death and occurs in 1 in 6,000 live births. view more (2008-12-17)
Penn researchers gain new insights on spinal muscular atrophy
Researchers from the University of Pennsylvania School of Medicine discovered that the effect of a protein deficiency, which is the basis of the neuromuscular disease spinal muscular atrophy (SMA), is not restricted to motor nerve cells, suggesting that SMA is a more general disorder. view more (2008-05-30)
ISU researchers find possible treatment for Spinal Muscular Atrophy
Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world. view more (2009-07-28)
Scientists discover possible new treatment for genetic diseases
Scientists from Imperial College London, the University of Leicester, and Hammersmith Hospital have found a way to stop certain types of genetic diseases from occurring by modifying the way DNA is turned into proteins. The research published in this month's Proceedings of the National Academy of Science shows how the researchers have been able to... view more... (2003-03-14)
MU logo News Bureau University of Missouri About the News Bureau Contact Us Home / News Releases / 2009 MU Researchers Discover Target that Could Ease Spinal Muscular Atrophy Symptoms
There is no cure for spinal muscular atrophy (SMA), a genetic disorder that causes the weakening of muscles and is the leading genetic cause of infant death, but University of Missouri researchers have discovered a new therapeutic target that improves deteriorating skeletal muscle tissue caused by SMA. The new therapy enhanced muscle strength,... view more... (2009-01-08)
CSHL shows correcting rna splicing may help treat spinal muscular atrophy
RNA splicing antisense technology studied at Cold Spring Harbor Laboratory (CSHL) effectively corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients, and is now ready to be tested in mouse models. view more (2007-03-13)
Genetic test for spinal muscular atrophy should be offered to all couples, says the ACMG
Carrier screening for spinal muscular atrophy (SMA)-a serious genetic disease affecting approximately 1 in 10,000 infants that causes progressive muscle weakness and death-should be made available to all families, according to a new practice guideline issued by the American College of Medical Genetics (ACMG). view more (2008-12-10)
A glimmer of hope in the struggle against neurodegenerative diseases: the virtues of proteins that can save dying neurons
Diseases characterized by neurodegeneration affect individuals over 50 years of age and they attack one particular class of neurons in the brain or spinal cord. The research interest of Professor Ann Kato and her team is principally focalized on ALS in which there is a progressive paralysis caused by the destruction of motor neurons which exist in... view more... (2002-01-25)
Cold Spring Harbor Laboratory Scientists Devise Potential Approach To Treat Spinal Muscular Atrophy
In the neuromuscular disease called spinal muscular atrophy, or SMA, a protein deficiency caused by a single gene mutation leads to serious damage in growing nerve cells and the muscles they control. view more (2008-04-07)
Treatment extends survival in mouse model of spinal muscular atrophy
Drug therapy can extend survival and improve movement in a mouse model of spinal muscular atrophy (SMA), new research shows. The study, carried out at the NIH's National Institute of Neurological Disorders and Stroke (NINDS), suggests that similar drugs might one day be useful for treating human SMA. view more (2007-02-23)
Study Examines Role of Helicobacter Pylori in Esophageal Cancer Development
Infection with bacteria that can cause peptic ulcers and distal stomach cancer may be associated with a reduced risk of a type of esophageal cancer called adenocarcinoma, according to a study in the March 3 issue of the Journal of the National Cancer Institute. However, that same study found that people infected with the bacteria, called... view more... (2004-03-03)
Researchers identify drug candidate for treating spinal muscular atrophy
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. view more (2009-11-05)
Drug blocks lethal motor-neuron disease in mice
Spinal muscular atrophy (SMA) is an inherited motor-neuron disease that, in its most severe form, leads to death before 2 years of age and for which there is no treatment. view more (2007-02-23)
Researchers discover molecular basis of a form of muscular dystrophy
A team of French and German researchers report in the May 2008 print issue of The FASEB Journal (http://www.fasebj.org) that people with limb-girdle muscular dystrophy are missing a protein called c-FLIP, which the body uses to prevent the loss of muscle tissue. view more (2008-04-30)
Neurological disease raises risk of complications from flu
As another flu season approaches, patients with neurological and neuromuscular disease are especially vulnerable to respiratory failure caused by influenza. view more (2005-11-02)
Early cardiac screening necessary for muscular dystrophy patients
Early diagnosis and treatment of heart disease may lead to longer life in Duchenne and Becker muscular dystrophy patients. view more (2005-10-31)
Patient-derived induced stem cells retain disease traits
hen neurons started dying in Clive Svendsen's lab dishes, he couldn't have been more pleased. The dying cells - the same type lost in patients with the devastating neurological disease spinal muscular atrophy - confirmed that the University of Wisconsin-Madison stem cell biologist had recreated the hallmarks of a genetic disorder in the lab, using... view more... (2008-12-22)
PET-CT detects muscular lymphoma better than CT
PET-CT is better for early detection of muscular lymphoma than CT alone, according to a new study conducted by radiologists at the University of Minnesota in Minneapolis. view more (2007-05-07)
Mice models developed at UCSD to benefit patients with multiple system atrophy
Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a series of transgenic mouse models of multiple system atrophy, a progressive, fatal neurological disorder. view more (2005-11-17)
UCLA stem cells scientists make electrically active motor neurons from iPS cells
Stem cells scientists at UCLA showed for the first time that human induced pluripotent stem (iPS) cells can be differentiated into electrically active motor neurons, a discovery that may aid in studying and treating neurological disorders. view more (2009-02-25)
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