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Is the spleen able to prohibit tumor cell proliferation?
Primary and metastatic tumors of the spleen are described as unusual, excluding involvement by lymphoma. Indeed, isolated splenic metastasis from colorectal carcinoma is not a common occurrence. Its rareness has been hypothetically explained by several characteristics of the spleen, such as anatomical, histological and immunological features.   view more (2007-10-17)

MicroRNA-mediated metastasis suppression
Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis.    view more (2009-10-29)

Experimental agent reduces breast cancer metastasis to bone
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer.   view more (2009-11-04)

18F-DG PET/CT can highly increase the detection of colorectal cancer
Combined positron emission tomography and computed tomography (PET/CT) is currently widely used in the clinical diagnosis of cancer to provide functional and morphological imaging.   view more (2007-10-11)

Which is accurate, CT or MRI?
Paraaortic lymph node metastasis in patients with pancreatico-biliary carcinoma has been reported as a definite predictor of early recurrence and shorter survival term.   view more (2008-05-21)

Early results indicate radiofreqency ablation useful in treating ovarian cancer metastasis
Percutaneous radiofrequency ablation, a procedure that uses a high frequency electric current to kill tumor cells, is effective in achieving local control in selected patients with metastasis from ovarian cancer.   view more (2006-09-29)

Scientists figure out how the immune system and brain communicate to control disease
In a major step in understanding how the nervous system and the immune system interact, scientists at The Feinstein Institute for Medical Research have identified a new anatomical path through which the brain and the spleen communicate.   view more (2008-07-22)

A new significance of LVD and angiogenic MVD is identified in human primary SCRC
Lymphangiogenesis and angiogenesis are critical processes for tumor growth, invasion and metastasis. Angiogenesis has established its role in the development and progression of a variety of malignancies, playing a crucial role in the dissemination of the tumor cells.   view more (2008-01-17)

Researchers identify mechanism used by gene to promote metastasis in human cancer cells
Virginia Commonwealth University Institute of Molecular Medicine and VCU Massey Cancer Center researchers have discovered how a gene, melanoma differentiation associated gene-9/syntenin (mda-9/syntenin), interacts with an important signaling protein to promote metastasis in human melanoma cells, a discovery that could one day lead to the... view more... (2008-09-30)

Scientists from the University of Navarra find 5 genes involved in the metastasis of breast tumours to the lung
The identification of five genes involve in the metastasis of breast tumours to the lung is the principal finding of a scientific team made up of two bodies from the University of Navarra, the Applied Medical Research Centre (CIMA) and the University Hospital of the University of Navarra.   view more (2008-06-23)

Molecules can block breast cancer's ability to spread
Researchers have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.   view more (2008-01-10)

RNA interference toward MMP-2 may be an effective therapeutic strategy for cancer
The invasion or metastasis of pancreatic cancer has been known to be a complex process involving many molecular mechanisms, of which proteolytic degradation of extracellular matrix (ECM) exerted by matrix metalloproteinases (MMPs) was considered to be an essential step.   view more (2009-03-09)

Can liver cirrhosis be partially cured?
The diffusion of hepatitis C virus infection worldwide is astonishing. Liver cirrhosis is present in at least 10-20% of these infected patients, with highly increasing health care and emotional costs.   view more (2007-10-11)

Molecular markers signal early metastases from ocular melanoma
Patients with melanoma of the eye are at risk for liver metastases, which are often not detected until they have turned into large, lethal tumors.   view more (2006-09-14)

New Discovery Raises Doubts About Use of Certain Targeted Therapies in Bladder Cancer
Researchers at the University of Virginia Health System have found that one of the genes commonly thought to promote the growth and spread of some types of cancers is in fact beneficial in bladder cancer - a major discovery that could significantly alter the way bladder cancers are treated in the future.    view more (2009-03-26)

Markers that can predict cancer spread could save women from unnecessary chemotherapy
Women with early breast cancer could avoid needless chemotherapy thanks to work carried out in Chicago on identifying biochemical markers which indicate whether or not cancer is likely to spread to other parts of the body, the 3rd European Breast Cancer Conference in Barcelona heard today (Saturday 23 March). Ruth Heimann, Associate Professor in... view more... (2002-03-21)

A new theoretical model of tumor growth and metastasis based on differences in tissue pressure
The HFSP Journal, the interdisciplinary journal for scientists conducting high quality, innovative research at the interface between biology and the physical sciences is pleased to announce that the latest article modelling of tumor growth and metastasis.   view more (2009-03-24)

Post-pregnancy events promote breast tumor metastasis
Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells.   view more (2006-02-03)

Genes found to play a role in breast cancer's spread to the brain
New research led by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) identifies three genes that specifically mediate the metastasis, or spread, of breast cancer to the brain and illuminates the mechanisms by which this spread occurs. The study was published online today in Nature.    view more (2009-05-07)

A potential molecular target for biotherapy esophageal squamous cell carcinomas
The cadherin superfamily has a correlate relationship with the invasion and metastasis of carcinoma.   view more (2009-02-19)
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