Stat3 Current Events | Stat3 News
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An effective target of biological therapy for hepatocellular carcinoma
It has been shown that constitutively activated STAT3 is detected in many HCC cell lines and tissues. This suggests that STAT3 is a promising molecular target for HCC gene therapy. view more (2009-06-15)
Search reveals molecules that block Stat 3
Finding molecules that block the activity of the oncogene Stat3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, said a Baylor College of Medicine researcher in a report that appears in the... view more... (2009-03-11)
Researchers Identify New Function of Protein in Cellular Respiration
Virginia Commonwealth University researchers have found that the protein Stat3 plays a key role in regulating mitochondria, the energy-producing machines of cells. This discovery could one day lead to the development of new treatments for heart disease to boost energy in failing heart muscle or to master the abnormal metabolism of cancer. view more (2009-01-29)
Signaling proteins may represent biomarkers for melanoma
For the first time, researchers studying patients with abnormal moles have identified proteins that could help predict whether such moles will progress into melanoma, the deadliest form of skin cancer. view more (2006-04-06)
STAT3 Gene Regulates Cancer Stem Cells in Brain Cancer
In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. view more (2009-08-10)
2 new compounds show promise for eliminating breast cancer tumors
Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors. view more (2008-11-19)
Jefferson researchers uncover new evidence of prolactin's possible role in breast cancer
Scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the hormone prolactin in breast cancer. view more (2007-10-01)
Discovery of good -- and bad -- liver stem cells raises possibility of new treatment
Many scientists believe up to 40 percent of liver cancer is caused by stem cells gone wild - master cells in the organ that have lost all growth control. But, despite years spent looking, no one has ever found these liver "cancer stem cells" - or even normal stem cells in the organ. Until now. view more (2008-02-11)
Cell-regulating gene may predict survival outcomes for breast cancer patients
A study led by researchers at Mount Sinai School of Medicine has shown that a cell-regulating gene overexpressed in about 30 to 50 percent of all breast cancers is associated with a better chance of survival and increased sensitivity to a cancer-fighting drug. view more (2006-09-06)
Scientists identify cause of Job's syndrome
The rare immunodeficiency disorder known as Job's syndrome is caused by a specific genetic mutation that both overstimulates and understimulates the human immune system, leading to harmful bacterial and fungal infections and the physical features characteristic of the syndrome. view more (2007-09-20)
Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue. view more (2007-12-11)
Finding that could shed light on 'golden staph,' candida and allergies
Recent scientific findings explain why patients with a rare immunodeficiency disorder are unusually susceptible to certain common infections. By revealing the exact molecular mechanisms involved, they also give us clues as to why some 'healthy' people are more prone to these infections than others, and suggest potential treatments. view more (2008-07-01)
Researchers identify cell pathway in colon cancer
For the one in 18 men and women who will be diagnosed with cancer of the colon and rectum during their lifetime and over 150,000 people diagnosed on a yearly basis, today's genetic research news offers some optimism. view more (2007-02-21)
Researchers identify cell pathway in colon cancer
For the one in 18 men and women who will be diagnosed with cancer of the colon and rectum during their lifetime and over 150,000 people diagnosed on a yearly basis, today's genetic research news offers some optimism. view more (2007-02-20)
What is the mechanism of the chronic radiation enteritis?
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. view more (2008-12-23)
New oncogene gives valuable insight into hepatocellular tumors in humans
The first identification of GP130 somatic activating mutations* in human tumours was announced today at EASL 2009, the Annual Meeting of the European Association for the Study of Liver Disease in Copenhagen, Denmark. view more (2009-04-23)
The difference between eye cells is-sumo?
Researchers at the Johns Hopkins University School of Medicine and Washington University School of Medicine have identified a key to eye development - a protein that regulates how the light-sensing nerve cells in the retina form. view more (2009-03-10)
Wealth of genomic hotspots discovered in embryonic stem cells
In a paper published in Cell on June 13, 2008, Singapore scientists at the Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) unveil an atlas that showing the location of "genomic hotspots" of essential protein "switches" (transcription factors) that are critical for maintaining the embryonic... view more... (2008-06-16)
Immune molecule that plays a powerful role in avoiding organ rejection identified
When a mouse's immune system is deciding whether to reject a skin graft, one powerful member of a molecular family designed to provoke such a response can effectively reduce the visibility of the mouse's own cells and help the graft survive, researchers say. view more (2008-06-17)
Potent spice works to block growth of melanoma in lab test
Curcumin, the pungent yellow spice found in both turmeric and curry powders, blocks a key biological pathway needed for development of melanoma and other cancers, say researchers from The University of Texas M. D. Anderson Cancer Center. view more (2005-07-13)
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