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New target for cancer therapy identified
A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development. view more (2006-09-22)
Baumann lab identifies elusive telomere RNA subunit in single cell model
The Stowers Institute's Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition. view more (2007-12-28)
Tissue engineering technique does not cause tumor growth
A gene therapy approach used in creating new arteries for older patients does not appear to cause cancer, according to a pilot study by Yale School of Medicine researchers reported in the Proceedings of the National Academy of Sciences. view more (2006-03-01)
UCSF study shows suppression of telomerase enzyme can inhibit spread of melanoma
UCSF researchers have found that the spread of melanoma can be inhibited by suppressing telomerase, the enzyme active in cancer cell growth. view more (2006-07-11)
UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
Human cancer cells divide and conquer. Unless physicians can control that division with surgery, chemotherapy or radiation, the wildly dividing cells will eventually destroy a person's life. view more (2008-07-11)
Researchers find way to make tumor cells easier to destroy
Tumors have a unique vulnerability that can be exploited to make them more sensitive to heat and radiation, researchers at Washington University School of Medicine in St. Louis report. view more (2008-05-07)
Short chromosomes put cancer cells in forced rest
A Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres. view more (2007-04-26)
Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes
Telomeres, structures that cap the ends of cells' chromosomes, grow shorter with each round of cell division unless a specialized enzyme replenishes them. Maintaining telomeres is thought to be important for healthy aging and cancer prevention. view more (2009-03-05)
Blame Our Evolutionary Risk of Cancer on Our Body Mass
A key enzyme that cuts short our cellular lifespan in an effort to thwart cancer has now been linked to body mass. view more (2006-12-06)
Researchers track down the genes that could put the brakes on breast cancer.
Normally, old or damaged cells are told to stop dividing and 'self-destruct' to prevent any mutations being duplicated and growing into tumours. But cancer cells usually ignore these messages and become 'immortal' allowing them to continue multiplying indefinitely and out of control. Scientists already know that an enzyme called 'telomerase' is... view more... (1999-02-22)
Measuring certain enzyme activity in urine shows promise for detection of bladder cancer
Measurement of an enzyme level (telomerase activity) in urine appears useful for detection of bladder cancer in men. view more (2005-10-26)
Researchers examine mechanisms that help cancer cells proliferate
A process that limits the number of times a cell divides works much differently than had been thought, opening the door to potential new anticancer therapies, researchers at UT Southwestern Medical Center report in the Aug. 7 issue of the journal Cell. view more (2009-09-02)
Mice regain ability to extend telomeres suggesting potential for dyskeratosis congenita therapy
The human genetic disease dyskeratosis congenita (DKC) is an autosomal dominant disease that leads to abnormalities in tissues with a rapid cell turnover - the skin, nails, bone marrow, lungs and gut. view more (2009-10-19)
A little telomerase isn't enough
Chromosome ends, or telomeres, are repetitive stretches of DNA that protect chromosomes in much the same way as plastic tips on shoelaces prevent the fabric from fraying. view more (2005-12-23)
Telomerase inhibition - a cancer therapy that is not always what it seems
Telomerase is a protein involved in cancer where it is present in 85 to 90% of all cases. Taking advantage of this fact, over the last years multiple new approaches have appeared that aim to inhibit telomerase activity as a new treatment strategy in human cancer. However, in the latest issue of the journal Oncogene scientists reveal that in some... view more... (2004-05-25)
The clue of genomic instability in breast cancer
New research has shown, using human tissue biopsies - a hypothesis that until now could only be argued indirectly using cell cultures - that the significant increase in genomic "disorder" that is associated with breast cancer occurs in the transition between the typical hyperplasia and the in situ carcinoma, coinciding with a reduction to a... view more... (2004-09-07)
New telomere discovery could help explain why cancer cells never stop dividing
A group working at the Swiss Institute for Experimental Cancer Research (ISREC) in collaboration with the University of Pavia has discovered that telomeres, the repeated DNA-protein complexes at the end of chromosomes that progressively shorten every time a cell divides, also contain RNA. view more (2007-10-05)
Gene mutations linked to hereditary lung disease
Scientists at Johns Hopkins have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings, published in the March 29, 2007 issue of the New England Journal of Medicine, may provide new directions in diagnosis and treatment for families that inherit genes for the disease, as well as for those that develop... view more... (2007-03-29)
Researchers use chemical from medicinal plants to fight HIV
Like other kinds of cells, immune cells lose the ability to divide as they age because a part of their chromosomes known as a telomere becomes progressively shorter with cell division. As a result, the cell changes in many ways, and its disease fighting ability is compromised. view more (2008-11-10)
Scientists identify possible cause of endometriosis
Endometriosis is a condition whereby patches of the inner lining of the womb appear in parts of the body other than the womb cavity. It can cause severe pain and affects approximately 15% of women of reproductive age. Endometriosis is also associated with infertility, with 50% of infertile women affected by the condition. view more (2008-08-06)
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