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Chromosome Assessment Could Predict Increased Risk Of Death From Age-related Disease (p 393)
US authors of a research letter in this week's issue of THE LANCET highlight how the measurement of the ends of chromosomes in older people could give an indication of their relative risks of dying from age-related diseases. The ends of chromosomes (telomeres) shorten with age, and this shortening may contribute to the increased risk of disease... view more... (2003-01-29)
'Ageing gene' could be passed on via X chromosome (p 507)
An observational study in this week's issue of THE LANCET sheds more light on the theory that ageing is associated with a shortening of chromosomes in somatic (ie. non-reproductive) cells. Results of the study suggest that the gene responsible for telomere shortening is inherited via the X chromosome. Previous research including a 2003 Lancet... view more... (2004-02-11)
RNAi and telomere length
A team of Russian scientists, led by Dr. Vladimir Gvozdev (Russian Academy of Sciences) reports on a novel link between RNAi and telomere maintenance in the Drosophila germline. view more (2006-02-01)
Enhanced skin cancer risk linked to defects in cellular aging controls
Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation. view more (2009-02-23)
Osteoarthritis may be sign of faster 'biological ageing'
Osteoarthritis, the degenerative inflammatory bone disease, may be a sign of faster "biological ageing," suggests research published ahead of print in the Annals of the Rheumatic Diseases. view more (2006-10-02)
New telomere discovery could help explain why cancer cells never stop dividing
A group working at the Swiss Institute for Experimental Cancer Research (ISREC) in collaboration with the University of Pavia has discovered that telomeres, the repeated DNA-protein complexes at the end of chromosomes that progressively shorten every time a cell divides, also contain RNA. view more (2007-10-05)
Atherosclerosis Could Be Linked To Premature Ageing (p 472)
A pilot study published in a research letter in this week's issue of The Lancet suggests that chromosomal changes associated with premature ageing may predispose individuals to atherosclerosis. Chromosomes end with telomeres, which shorten with cellular ageing; therefore, telomere length can be viewed as a biomarker of cell ageing. Nilesh Samani... view more... (2001-08-08)
New genetic biomarkers could predict coronary heart disease
New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future. Research carried out by Dr. M. Balasubramanyam and Dr.V.Mohan at the Madras Diabetes Research Foundation (India) shows that people who are pre-diabetic or who have Type 2 diabetes have much shorter telomeres1 and, since these... view more... (2007-04-02)
Mice regain ability to extend telomeres suggesting potential for dyskeratosis congenita therapy
The human genetic disease dyskeratosis congenita (DKC) is an autosomal dominant disease that leads to abnormalities in tissues with a rapid cell turnover - the skin, nails, bone marrow, lungs and gut. view more (2009-10-19)
Baumann lab identifies elusive telomere RNA subunit in single cell model
The Stowers Institute's Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition. view more (2007-12-28)
Could vitamin D, a key milk nutrient, affect how you age?
There is a new reason for the 76 million baby boomers to grab a glass of milk. Vitamin D, a key nutrient in milk, could have aging benefits linked to reduced inflammation, according to a new study published in the American Journal of Clinical Nutrition. view more (2007-11-09)
Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
An abnormality of chromosomes long associated with diseases of aging has, for the first time, been linked to colon cancer in people 50 years old and younger, an age group usually considered young for this disease. view more (2007-10-29)
Common weed could provide clues on aging and cancer
A common weed and human cancer cells could provide some very uncommon details about DNA structure and its relationship with telomeres and how they affect cellular aging and cancer, according to a team led by scientists from Texas A&M University and the University of Cincinnati (UC). view more (2009-10-27)
When cells go bad
When a cell's chromosomes lose their ends, the cell usually kills itself to stem the genetic damage. But University of Utah biologists discovered how those cells can evade suicide and start down the path to cancer. view more (2008-10-01)
Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
In families with a high incidence of Li-Fraumeni syndrome, the ends of individuals' chromosomes act somewhat like a lit fuse, according to researchers at The Hospital for Sick Children in Toronto. view more (2007-02-16)
First sister study results reinforce the importance of healthy living
Women who maintain a healthy weight and who have lower perceived stress may be less likely to have chromosome changes associated with aging than obese and stressed women, according to a pilot study that was part of the Sister Study. view more (2009-03-17)
Evidence of rapid evolution is found at the tips of chromosomes
In terms of their telomeres, mice are more complicated than humans. That's the finding from a recent Rockefeller University study, which shows that mice have two proteins working together to do the job of a single protein in human cells. view more (2006-08-02)
Tiny roundworm's telomeres help scientists to tease apart different types of aging
The continual and inevitable shortening of telomeres, the protective "caps" at the end of all 46 human chromosomes, has been linked to aging and physical decline. view more (2005-08-08)
A little telomerase isn't enough
Chromosome ends, or telomeres, are repetitive stretches of DNA that protect chromosomes in much the same way as plastic tips on shoelaces prevent the fabric from fraying. view more (2005-12-23)
Researchers use chemical from medicinal plants to fight HIV
Like other kinds of cells, immune cells lose the ability to divide as they age because a part of their chromosomes known as a telomere becomes progressively shorter with cell division. As a result, the cell changes in many ways, and its disease fighting ability is compromised. view more (2008-11-10)
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