Telomeres Current Events | Telomeres News
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New genetic biomarkers could predict coronary heart disease
New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future. Research carried out by Dr. M. Balasubramanyam and Dr.V.Mohan at the Madras Diabetes Research Foundation (India) shows that people who are pre-diabetic or who have Type 2 diabetes have much shorter telomeres1 and, since these... view more... (2007-04-02)
Handle with care: Telomeres resemble DNA fragile sites
Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. view more (2009-07-10)
Short chromosomes put cancer cells in forced rest
A Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres. view more (2007-04-26)
Chromosome Assessment Could Predict Increased Risk Of Death From Age-related Disease (p 393)
US authors of a research letter in this week's issue of THE LANCET highlight how the measurement of the ends of chromosomes in older people could give an indication of their relative risks of dying from age-related diseases. The ends of chromosomes (telomeres) shorten with age, and this shortening may contribute to the increased risk of disease... view more... (2003-01-29)
Researchers identify protein-telomere interactions that could be key in treating cancer
A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. view more (2009-09-01)
RNAi and telomere length
A team of Russian scientists, led by Dr. Vladimir Gvozdev (Russian Academy of Sciences) reports on a novel link between RNAi and telomere maintenance in the Drosophila germline. view more (2006-02-01)
Normal chromosome ends elicit a limited DNA damage response
Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes. view more (2005-11-28)
Common weed could provide clues on aging and cancer
A common weed and human cancer cells could provide some very uncommon details about DNA structure and its relationship with telomeres and how they affect cellular aging and cancer, according to a team led by scientists from Texas A&M University and the University of Cincinnati (UC). view more (2009-10-27)
Tiny roundworm's telomeres help scientists to tease apart different types of aging
The continual and inevitable shortening of telomeres, the protective "caps" at the end of all 46 human chromosomes, has been linked to aging and physical decline. view more (2005-08-08)
New telomere discovery could help explain why cancer cells never stop dividing
A group working at the Swiss Institute for Experimental Cancer Research (ISREC) in collaboration with the University of Pavia has discovered that telomeres, the repeated DNA-protein complexes at the end of chromosomes that progressively shorten every time a cell divides, also contain RNA. view more (2007-10-05)
Gene mutations linked to hereditary lung disease
Scientists at Johns Hopkins have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings, published in the March 29, 2007 issue of the New England Journal of Medicine, may provide new directions in diagnosis and treatment for families that inherit genes for the disease, as well as for those that develop... view more... (2007-03-29)
Researchers examine mechanisms that help cancer cells proliferate
A process that limits the number of times a cell divides works much differently than had been thought, opening the door to potential new anticancer therapies, researchers at UT Southwestern Medical Center report in the Aug. 7 issue of the journal Cell. view more (2009-09-02)
Evidence of rapid evolution is found at the tips of chromosomes
In terms of their telomeres, mice are more complicated than humans. That's the finding from a recent Rockefeller University study, which shows that mice have two proteins working together to do the job of a single protein in human cells. view more (2006-08-02)
Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
An abnormality of chromosomes long associated with diseases of aging has, for the first time, been linked to colon cancer in people 50 years old and younger, an age group usually considered young for this disease. view more (2007-10-29)
UAB Researchers Discover a New Mechanism Involved in Predisposition to Cancer
A team of researchers at the Universitat Autònoma de Barcelona (UAB) has discovered a new mechanism that accelerates the shortening of telomeres (structures that protect the ends of chromosomes) involved in genetic instability and a predisposition to cancer. The research has been published in the journal Human Molecular Genetics. view more (2002-02-26)
Atherosclerosis Could Be Linked To Premature Ageing (p 472)
A pilot study published in a research letter in this week's issue of The Lancet suggests that chromosomal changes associated with premature ageing may predispose individuals to atherosclerosis. Chromosomes end with telomeres, which shorten with cellular ageing; therefore, telomere length can be viewed as a biomarker of cell ageing. Nilesh Samani... view more... (2001-08-08)
'Ageing gene' could be passed on via X chromosome (p 507)
An observational study in this week's issue of THE LANCET sheds more light on the theory that ageing is associated with a shortening of chromosomes in somatic (ie. non-reproductive) cells. Results of the study suggest that the gene responsible for telomere shortening is inherited via the X chromosome. Previous research including a 2003 Lancet... view more... (2004-02-11)
Baumann Lab demonstrates role of protein in distinguishing chromosome ends from DNA breaks
The Stowers Institute's Baumann Lab has demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. view more (2009-09-18)
Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
In families with a high incidence of Li-Fraumeni syndrome, the ends of individuals' chromosomes act somewhat like a lit fuse, according to researchers at The Hospital for Sick Children in Toronto. view more (2007-02-16)
DNA repair teams' motto: 'To protect and serve'
When you dial 911 you expect rescuers to pull up at your front door, unload and get busy-not park the truck down the street and eat donuts. view more (2006-11-17)
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