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New genetic biomarkers could predict coronary heart disease
New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future. Research carried out by Dr. M. Balasubramanyam and Dr.V.Mohan at the Madras Diabetes Research Foundation (India) shows that people who are pre-diabetic or who have Type 2... view more (2007-04-02)

Short chromosomes put cancer cells in forced rest
A Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres.   view more (2007-04-26)

Chromosome Assessment Could Predict Increased Risk Of Death From Age-related Disease (p 393)
US authors of a research letter in this week's issue of THE LANCET highlight how the measurement of the ends of chromosomes in older people could give an indication of their relative risks of dying from age-related diseases. The ends of chromosomes (telomeres) shorten with age, and this shortening... view more (2003-01-29)

RNAi and telomere length
A team of Russian scientists, led by Dr. Vladimir Gvozdev (Russian Academy of Sciences) reports on a novel link between RNAi and telomere maintenance in the Drosophila germline.   view more (2006-02-01)

Normal chromosome ends elicit a limited DNA damage response
Researchers at the Salk Institute for Biological Studies discovered that cells co-opted the machinery that usually repairs broken strands of DNA to protect the integrity of chromosomes.   view more (2005-11-28)

Tiny roundworm's telomeres help scientists to tease apart different types of aging
The continual and inevitable shortening of telomeres, the protective "caps" at the end of all 46 human chromosomes, has been linked to aging and physical decline.   view more (2005-08-08)

New telomere discovery could help explain why cancer cells never stop dividing
A group working at the Swiss Institute for Experimental Cancer Research (ISREC) in collaboration with the University of Pavia has discovered that telomeres, the repeated DNA-protein complexes at the end of chromosomes that progressively shorten every time a cell divides, also contain RNA.   view more (2007-10-05)

Gene mutations linked to hereditary lung disease
Scientists at Johns Hopkins have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings, published in the March 29, 2007 issue of the New England Journal of Medicine, may provide new directions in diagnosis and treatment for families that inherit genes... view more (2007-03-29)

Evidence of rapid evolution is found at the tips of chromosomes
In terms of their telomeres, mice are more complicated than humans. That's the finding from a recent Rockefeller University study, which shows that mice have two proteins working together to do the job of a single protein in human cells.   view more (2006-08-02)

Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
An abnormality of chromosomes long associated with diseases of aging has, for the first time, been linked to colon cancer in people 50 years old and younger, an age group usually considered young for this disease.   view more (2007-10-29)

UAB Researchers Discover a New Mechanism Involved in Predisposition to Cancer
A team of researchers at the Universitat Autònoma de Barcelona (UAB) has discovered a new mechanism that accelerates the shortening of telomeres (structures that protect the ends of chromosomes) involved in genetic instability and a predisposition to cancer. The research has been published... view more (2002-02-26)

Atherosclerosis Could Be Linked To Premature Ageing (p 472)
A pilot study published in a research letter in this week's issue of The Lancet suggests that chromosomal changes associated with premature ageing may predispose individuals to atherosclerosis. Chromosomes end with telomeres, which shorten with cellular ageing; therefore, telomere length can be... view more (2001-08-08)

'Ageing gene' could be passed on via X chromosome (p 507)
An observational study in this week's issue of THE LANCET sheds more light on the theory that ageing is associated with a shortening of chromosomes in somatic (ie. non-reproductive) cells. Results of the study suggest that the gene responsible for telomere shortening is inherited via the X... view more (2004-02-11)

Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
In families with a high incidence of Li-Fraumeni syndrome, the ends of individuals' chromosomes act somewhat like a lit fuse, according to researchers at The Hospital for Sick Children in Toronto.   view more (2007-02-16)

DNA repair teams' motto: 'To protect and serve'
When you dial 911 you expect rescuers to pull up at your front door, unload and get busy-not park the truck down the street and eat donuts.   view more (2006-11-17)

A little telomerase isn't enough
Chromosome ends, or telomeres, are repetitive stretches of DNA that protect chromosomes in much the same way as plastic tips on shoelaces prevent the fabric from fraying.   view more (2005-12-23)

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
Human cancer cells divide and conquer. Unless physicians can control that division with surgery, chemotherapy or radiation, the wildly dividing cells will eventually destroy a person's life.   view more (2008-07-11)

Oncologists could gain therapeutic advantage by targeting telomere protein
Inactivating a protein called mammalian Rad9 could make cancer cells easier to kill with ionizing radiation, according to research at Washington University School of Medicine in St. Louis.   view more (2006-02-17)

FISH-ing for links between cancer and aging
Wielding a palette of chromosome paints, scientists at the Salk Institute for Biological Studies have taken a step closer to understanding the relationship between aging and cancer by visualizing chromosomes of cells from patients with a heritable premature aging disease known as Werner Syndrome.   view more (2007-02-06)

Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
New research from scientists at UT Southwestern Medical Center and the Dallas Veterans Affairs Medical Center underscores the importance of preventing recurring acid reflux while also uncovering tantalizing clues on how typical acid reflux can turn potentially cancerous.   view more (2007-08-10)

New target for cancer therapy identified
A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development.   view more (2006-09-22)

Telomerase inhibition - a cancer therapy that is not always what it seems
Telomerase is a protein involved in cancer where it is present in 85 to 90% of all cases. Taking advantage of this fact, over the last years multiple new approaches have appeared that aim to inhibit telomerase activity as a new treatment strategy in human cancer. However, in the latest issue of... view more (2004-05-25)

When cells go bad
When a cell's chromosomes lose their ends, the cell usually kills itself to stem the genetic damage. But University of Utah biologists discovered how those cells can evade suicide and start down the path to cancer.   view more (2008-10-01)

Hotspots found for chromosome gene swapping
Crossovers and double-strand DNA breaks do not occur randomly on yeast chromosomes during meiosis, but are greatly influenced by the proximity of the chromosome's telomere, according to research in the laboratory of Whitehead Fellow Andreas Hochwagen.   view more (2007-11-30)

The clue of genomic instability in breast cancer
New research has shown, using human tissue biopsies - a hypothesis that until now could only be argued indirectly using cell cultures - that the significant increase in genomic "disorder" that is associated with breast cancer occurs in the transition between the typical hyperplasia and the in situ... view more (2004-09-07)
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