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'Nurse cells' make life and death decisions for infection-fighting cells
"Nurse cells" play an important role in deciding which developing infection-fighting cells, called T cells, live and which die, according to research funded by the National Science Foundation (NSF) and reported in the June issue of the journal Experimental Biology and Medicine. view more (2007-05-31)
Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
The secret to longevity may lie in an enzyme with the ability to promote a robust immune system into old age by maintaining the function of the thymus throughout life, according to researchers studying an "anti-aging" mouse model that lives longer than a typical mouse. view more (2009-07-13)
UBC research finds molecular
University of British Columbia researchers have discovered a "molecular key" that could help increase the success of blood stem cell transplants, a procedure currently used to treat diseases such as leukemia, Hodgkin's lymphoma and aplastic anemia. view more (2009-04-23)
Thymus transplants gives hope to babies with fatal immune disease
"My baby is doing what other babies her age are doing -- she's feeding herself, putting on her own clothes and she loves to dance." view more (2007-05-16)
Cells on path to becoming mature T-cells more flexible than commonly thought
Contrary to the currently accepted model of T-cell development, researchers at the University of Pennsylvania School of Medicine have found that juvenile cells on their way to becoming mature immune cells can develop into either T cells or other blood-cell types versus only being committed to the T-cell path. view more (2008-04-10)
Old mystery solved, revealing origin of regulatory T cells that 'police' and protect the body
More than 150 years after the discovery of Hassall's corpuscles in 1849, the function of these round blobs of cells in the human thymus gland has now been explained. The answer, in turn, ends an intense hunt for the origin of regulatory T cells that has been under way for years. view more (2005-10-13)
Identification of protein able to stimulate production of T-cells
A team of Canadian and Finnish scientists has identified a protein able to stimulate the production of T-cells, the white blood cells involved in the recognition and the elimination of infectious agents. view more (2008-07-23)
New study shows that important gene controls the ability of the thymus to produce disease-fighting T-cells after an organism's birth
New research, just published by researchers from the University of Georgia, provides the first evidence that a key gene may be crucial to maintaining the production of the thymus and its disease-fighting T-cells after an animal's birth. view more (2008-11-07)
Mice stressed in simulated weightlessness show organ atrophy
A ground-based, experimental model used to simulate astronaut weightlessness in space has provided Rutgers scientists an opportunity to study the effects of stress on immune organs. view more (2007-09-04)
Rare disorder gives modelers first glimpse at immune system development
Children born without thymus glands have given Duke University Medical Center researchers a rare opportunity to watch as a new immune system develops its population of infection-fighting T-cells. view more (2009-06-17)
UCLA researchers develop T-cells from human embryonic stem cells
Researchers from the UCLA AIDS Institute and the Institute for Stem Cell Biology and Medicine have demonstrated for the first time that human embryonic stem cells can be genetically manipulated and coaxed to develop into mature T-cells, raising hopes for a gene therapy to combat AIDS. view more (2006-07-05)
Mayo Clinic boosts immune system
Mayo Clinic researchers have discovered a way to dramatically boost the output of immune system cells from the thymus, which may lead to improved cancer vaccines, as well as to ways to otherwise strengthen immune responses. view more (2005-09-23)
Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
Nearly a decade ago, now-Nobel laureates Craig Mello and Andrew Fire discovered that they could insert short RNA molecules into worms and shut down specific genes. view more (2007-08-02)
Amyotrophic lateral sclerosis may involve a form of sudden, rapid aging of the immune system
Premature aging of the immune system appears to play a role in the development of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to research scientists from the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center, the Weizmann Institute of Science in Israel, and Sheba Medical Center in Israel. view more (2009-10-09)
Aggressive stem cells might improve transplant outcome
Investigators at St. Jude Children's Research Hospital have demonstrated in mice a way that might reduce the time it takes for a bone marrow transplant to rebuild a child's immune system, and so reduce the risk of potentially fatal virus infections that can occur during this time. view more (2006-12-08)
New pathways for autoimmune treatment identified
A rare genetic defect that can trigger a host of diseases from type 1 diabetes to alopecia has helped explain the imbalance of immune regulator and killer cells in autoimmune disease. view more (2006-05-30)
Don't be a stranger to yourself
One of the most important tasks of the immune system is to identify what is foreign and what is self. If this distinction fails, then the body's own structures will be attacked, the result of which could be an autoimmune disease such as diabetes mellitus type 1 or multiple sclerosis. view more (2009-03-16)
Study identifies key player in the body's immune response to chronic stress
Osteopontin (OPN), a protein molecule involved in many different cellular processes, plays a significant role in immune deficiency and organ atrophy following chronic physiological stress, resulting in increased susceptibility to illness. view more (2007-09-04)
Genetic study shows direct link between vitamin D and MS susceptibility 'gene'
Researchers have found evidence that a direct interaction between vitamin D and a common genetic variant alters the risk of developing multiple sclerosis (MS). view more (2009-02-05)
UF researchers track genetic journey of HIV from birth to death
University of Florida scientists have discovered how HIV evolves over the course of a person's lifetime into a more deadly form that heralds the onset of full-blown AIDS. The findings could pave the way for new therapeutic agents that target the virus earlier in the disease process, before it takes a lethal turn, researchers say. view more (2007-10-17)
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