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Towards a unified model of transcription termination
Dr. David Bentley (University of Colorado School of Medicine) and colleagues have developed a new, unified model for transcription termination by RNA Poymerase II. view more (2006-04-07)
Rewrite the textbooks: Transcription is bidirectional
Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. view more (2009-01-26)
Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
Genomatix Software with businesses in Munich, Germany and Ann Arbor, Michigan released today that the group of Kenneth R. Boheler at the National Institute on Aging, National Institutes of Health, Baltimore, Md published some remarkable work on embryonic stem (ES) cells. view more (2008-03-04)
Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
In an upcoming issue of G&D, Drs. Maria Divina Deato and Robert Tjian (HHMI, UC Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. view more (2007-08-20)
Another Key to the p53 Door
Researchers at the Uppsala Branch of the Ludwig Institute for Cancer Research (LICR) have discovered that the transcription factor Yin Yang 1 (YY1) is a novel regulator of the tumor suppressor p53, which is inactivated in at least half of all human cancers. The p53 transcription factor plays a vital role in preventing cancer onset, by stimulating... view more... (2004-07-29)
Don't move a muscle: Evolutionary insight into myogenesis
In a paper released online ahead of its scheduled December 15th publication date, Dr. Michael Krause (NIH) and colleagues detail the transcription network that drives muscle development in the roundworm C. elegans, and make a strong argument for an evolutionarily conserved program of myogenesis in all animals. view more (2006-12-07)
Researchers create mouse lacking key inflammation gene
In a paper published yesterday in The Proceedings of the National Academy of Science (PNAS), researchers from Boston University School of Dental Medicine generated a mouse model exhibiting reduced inflammation. view more (2006-09-07)
Gene regulation in humans is closer than expected to simple organisms
Gene networks are some of the most basic features of a living organism. An external or internal stimulus activates some genes, which in turn control others genes whose activity turns on or off various biological processes (such as the cell cycle, energy production, DNA repair, cellular suicide etc). view more (2007-08-30)
Making sense of the genome
Almost every week we hear of a new genome sequence being completed, yet turning sequence information into knowledge about what individual genes do is very difficult. An article published in Journal of Biology this week will simplify this task, as it describes a new online tool that dramatically improves predictions of how individual genes are... view more... (2003-05-22)
UCLA researchers unravel a mystery about DNA
UCLA researchers in collaboration with researchers at Rutgers University have solved longstanding mysteries surrounding DNA transcription, the first step in carrying out instructions contained in our genes. view more (2006-11-17)
UC researchers find new ways to regulate genes, reduce heart damage
Researchers at the University of Cincinnati (UC) are looking for ways to reduce or prevent heart damage by starting where the problem often begins: in the genes. view more (2008-06-23)
What Are Muscle Proteins Doing in the Nucleus?
The proteins actin and myosin have a firm place in the muscles where they are responsible for contraction. While recent investigations have shown that they are also found in the nucleus, it has been unclear to date just what they are doing there. Now an international team of investigators headed by Professor Dr. Ingrid Grummt, head of the Division... view more... (2005-02-01)
Fibroblasts invade at a snail's pace
A transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue of the Journal of Cell Biology. view more (2009-02-02)
Study will explore genetics of congenital limb and heart malformations
New research published in the August issue of the Journal of Cell Biology explains for the first time why congenital heart defects so often occur with limb deformities. view more (2006-08-21)
Genetic 'tag team' keeps cells on cycle
By surveying the activity of thousands of genes at several different time points, researchers at the Duke Institute for Genome Sciences & Policy have uncovered new evidence that a network of influential genes act as a kind of genetic tag team to orchestrate one of the most fundamental aspects of all life: the cell cycle. view more (2008-05-08)
Cocaine-linked genes enhance behavioral effects of addiction
New research sheds light on how cocaine regulates gene expression in a crucial reward region of the brain to elicit long-lasting changes in behavior. view more (2009-05-14)
Honey bee genome holds clues to social behavior
By studying the humble honey bee, researchers at the University of Illinois at Urbana-Champaign have come a step closer to understanding the molecular basis of social behavior in humans. view more (2006-10-24)
Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease. view more (2007-11-14)
Gladstone scientists identify key factors in heart cell creation
Scientists at the Gladstone Institute of Cardiovascular Disease have identified for the first time key genetic factors that drive the process of generating new heart cells. view more (2009-04-27)
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