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Lamin B locks up Oct-1
A large fraction of the transcription factor Oct-1 is associated with the inner nuclear envelope, but how and why it is retained there was unknown. view more (2009-01-12)
Tribble 3 can induce non-alcoholic fatty liver disease?
Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. view more (2009-06-11)
New research into the mechanisms of gene regulation
A team led by Penn State's Ross Hardison, T. Ming Chu Professor of Biochemistry and Molecular Biology, has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth. view more (2009-11-20)
Baylor researchers unravel mystery of DNA conformation
An iconic photograph of Nobel laureates Drs. Francis Crick and James Watson show the pair discussing with a rigid model of the famous double helix. view more (2009-07-14)
Researchers map infectious hepatitis B virus
Using electron cryomicroscopy and computer image analysis, the scientists visualized two intermediate forms of the virus that exist within infected cells. In addition, they were able to determine a three-dimensional map by analysis of infectious hepatitis B virus isolated from patient blood samples. view more (2006-06-26)
New understanding of Ewing's sarcoma suggests novel treatment strategy
Using molecular and cell-based models, researchers at Georgetown University Medical Center have refined the picture of how a cancer-promoting protein associated with Ewing's sarcoma functions. view more (2006-06-01)
Computer users are digitizing books quickly and accurately with Carnegie Mellon method
Millions of computer users collectively transcribe the equivalent of 160 books each day with better than 99 percent accuracy, despite the fact that few spend more than a few seconds on the task and that most do not realize they are doing valuable work, Carnegie Mellon University researchers reported today in Science Express. view more (2008-08-15)
Protein protects embryonic stem cells' versatility and self-renewal
A protein known as REST blocks the expression of a microRNA that prevents embryonic stem cells from reproducing themselves and causes them to differentiate into specific cell types, scientists at The University of Texas M. D. Anderson Cancer Center report in the journal Nature. view more (2008-03-24)
Insights into activity-dependent neuronal growth through RSRF-supported research
Brain-derived neurotrophic factor (BDNF) has been a subject of keen interest in neuroscientific circles for several years, turning up in studies of conditions ranging from central hypoventilation syndrome to obsessive-compulsive disorder, depression, bipolar disorder and schizophrenia - a range of disorders uncannily parallel to those produced by... view more... (2006-10-23)
Discovery may lead to powerful new therapy for asthma
University of Texas Medical Branch at Galveston researchers have found that a single enzyme is apparently critical to most allergen-provoked asthma attacks - and that activity of the enzyme, known as aldose reductase, can be significantly reduced by compounds that have already undergone clinical trials as treatments for complications of diabetes. view more (2009-08-12)
Fly with brain tumor may shed light on cancer causing genes
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain tumors develop. The causes of brain tumor... view more... (2004-04-14)
2-protein team would be lost without each other
Just as a hard-charging person sometimes needs a calming partner to be more effective, so it is with a pair of critical proteins that promote cell division and growth in the rapidly expanding root tip of plants. view more (2007-04-20)
Scientists discover age-regulated cellular activities that protect against protein aggregation
Alzheimer's disease now strikes more than one in 30 Americans, and about half the population that lives past 85 acquires Alzheimer's. view more (2006-08-14)
Masterminding muscle development
Dr. Lizi Wu (Dana Farber Cancer Institute) and colleagues report on a critical role for one of the three mammalian mastermind genes (Maml1) in myogenesis - assigning that first biological function to the mammalian MAML Notch co-activators. view more (2006-02-28)
New paper describes connections between Circadian and metabolic systems
A paper by University of Notre Dame biologist Giles Duffield and a team of researchers offers new insights into a gene that plays a key role in modulating the body's Circadian system and may also simultaneously modulate its metabolic system. view more (2009-11-13)
UC Davis researchers discover genetic switch involved in cells' response to radiation therapy
UC Davis Cancer Center researchers have discovered a genetic switch that causes cancer cells to become more sensitive to a drug administered to enhance radiation therapy effectiveness. view more (2005-11-17)
CHANGES IN PROCESSES CAN SUBSTANTIALLY REDUCE ERROR
Nightingale and colleagues from the Department of Medicine at the University of Birmingham describe a rules based system for the prescribing and recording of drugs given to patients. The system can be accessed from the bedside through wireless terminals. During 11 months of monitoring, the system prevented 58 unsafe prescriptions and gave over 700... view more... (2000-03-14)
Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease? view more (2009-11-19)
Can periodontal disease act as a risk factor for HIV-1?
Today, during the 87th General Session of the International Association for Dental Research, convening at the Miami Beach Convention Center, a group of scientists from Nihon University (Tokyo, Japan) will present findings suggesting that periodontal disease could act as a risk factor for reactivating latent HIV-1 in affected individuals. view more (2009-04-03)
A novel model to pinpoint human androgen receptor targets developed
A novel computational model to pinpoint androgen receptor targets within the human genome was recently reported. view more (2005-11-01)
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