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Researchers identify cancer-causing gene in many colon cancers
Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer. view more (2008-09-15)
Stowers Institute's Workman Lab discovers novel histone demethylase protein complex
The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell. view more (2008-12-08)
How RNA polymerase II gets the go-ahead for gene transcription
All cells perform certain basic functions. Each must selectively transcribe parts of the DNA that makes up its genome into RNAs that specify the structure of proteins. view more (2009-10-12)
Deciphering the regulatory code
Embryonic development is like a well-organised building project, with the embryo's DNA serving as the blueprint from which all construction details are derived. view more (2009-11-06)
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities. view more (2009-11-12)
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
Synopsis: Two papers from Woods and colleagues describe novel roles for members of the dual specificity tyrosine phosphorylated and regulated kinase (DYRK) family. In one, DYRK1A is shown to phosphorylate a novel site in the transcription factor FKHR (a forkhead protein) regulating its nuclear presence and transcriptional activity. In the second... view more... (2001-04-24)
Professor sheds light on DNA mechanisms
By manipulating individual atoms in DNA and forming unique molecules, a Georgia State University researcher hopes to open new avenues in research towards better understanding the mechanisms of DNA replication and transcription, and perhaps leading to new treatments for diseases. view more (2009-07-20)
Enzyme crystal structure reveals 'unexpected' genome repair functions
The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes. view more (2006-04-07)
A brave new "old world" of RNA
A new function for RNA, which further elucidates how genes are expressed and regulated, is described on the 25th of November issue of the journal Nature. view more (2004-11-22)
Cracking the genetic code for control of gene expression
Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. view more (2006-01-13)
Cancer: Another step towards medication
The gene Myc is an important factor for the growth of organisms by cell division. It causes the production of a protein which, as a transcription factor, controls the expression of up to 15 % of all human genes. view more (2009-03-18)
How cells change gears: New insights published in Nature Genetics
Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." This computational biology work from the Jacobs School of Engineering's bioengineering department could lead to new ideas for curbing unwanted cell... view more... (2009-04-21)
No-entry zones for AIDS virus
The AIDS virus inserts its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center have now shown for the first time that the virus almost entirely spares particular sites in the human genetic material in this process. This finding may be useful for developing new, specific AIDS drugs. view more (2009-11-13)
Discovery in plant virus may help prevent HIV and similar viruses
In a study that could lead to new ways to prevent infection by human immunodeficiency virus (HIV) and similar organisms, Purdue University researchers have been able to genetically modify a plant to halt reproduction of a related virus. view more (2007-08-01)
MIT researcher presents new view of how the cortex forms
A leading neuroscientist at MIT and one from the University of California at San Francisco (UCSF) report in the Nov. 4 special issue of Science dedicated to the brain that the controversy is over: The "protomap" and "protocortex" theories of brain development are dead. view more (2005-11-14)
A tiny protein plays a big role in DNA repair
Two of DNA's worst enemies, ultraviolet light and chemical carcinogens, can wreak havoc on the molecule by mutating individual nucleotides or changing its physical structure. view more (2006-05-09)
Researchers discover key to human embryonic stem-cell potential
What exactly makes a stem cell a stem cell? The question may seem simplistic, but while we know a great deal of what stem cells can do, we don't yet understand the molecular processes that afford them such unique attributes. view more (2005-09-09)
FOXO factor promotes survival of oxygen-deprived cancer cells
Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on the growth of tumors, depending on whether or not the tumor cells have enough oxygen. view more (2007-12-28)
A Morse code for human cells
Morse code is a simple, effective and clear method of communication and now scientists believe that cells in our body may also be using patterns of signals to switch genes on and off. The discovery may have major implications for the pharmaceutical industry as the signalling molecules that are targeted by drugs may have more than one purpose. The... view more... (2005-01-06)
Enzyme alerts cell's powerful army to repair DNA damage
Scientists know that inside each cell, a little engine called RNA polymerase II does one essential job: It copies instructions from genes in the nucleus that get carried to production units in the rest of the cell to support our daily needs. view more (2007-09-06)
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