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Wealth of genomic hotspots discovered in embryonic stem cells
In a paper published in Cell on June 13, 2008, Singapore scientists at the Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) unveil an atlas that showing the location of "genomic hotspots" of essential protein "switches" (transcription factors) that are critical for maintaining the embryonic... view more... (2008-06-16)
Molecular alliance that sustains embryonic stem cell state
One of the four ingredients in the genetic recipe that scientists in Japan and the U.S. followed last year to persuade human skin cells to revert to an embryonic stem cell state, is dispensable in ES cells, thanks to the presence of a molecular alliance between a specific group of key proteins known as transcription factors. view more (2008-03-05)
MIT: Engineered yeast speeds ethanol production
MIT scientists have engineered yeast that can improve the speed and efficiency of ethanol production, a key component to making biofuels a significant part of the U.S. energy supply. view more (2006-12-08)
Scientists Identify Key Roadblock to Gene Expression
A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster. view more (2008-05-09)
Lithium and bone healing
Researchers have described a novel molecular pathway that may have a critical role in bone healing and have suggested that lithium, which affects this pathway, has the potential to improve fracture healing. view more (2007-07-31)
Pigeons provide clue to solving common problem in heart patients
Through studying pigeons with genetic heart disease, researchers at Wake Forest University School of Medicine have discovered a clue about why some patients' heart vessels are prone to close back up after angioplasty. view more (2006-07-31)
Scientists discover a genetic code for organizing DNA within the nucleus
DNA - the long, thin molecule that carries our hereditary material - is compressed around protein scaffolding in the cell nucleus into tiny spheres called nucleosomes. view more (2006-07-20)
Channels of cellular communication
A potential new channel of communication between different cellular compartments has been discovered by researchers at the University of Leeds. Dr Jim Deuchars` group show how the protein P2X7, which forms a channel known to mediate ion movements between cells and their external environment, may also work internally, facilitating communication... view more... (2002-11-08)
CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery to regulate gene activity
During gene transcription - the process inside the nucleus of cells by which DNA, the genetic material, is copied into RNA - a large, ever-changing multiprotein complex is enlisted to assist the DNA-copying enzyme in its challenging job. view more (2008-12-19)
Signaling for cartilage
Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences. view more (2006-11-28)
Scientists synthesize memory in yeast cells
Harvard Medical School researchers have successfully synthesized a DNA-based memory loop in yeast cells, findings that mark a significant step forward in the emerging field of synthetic biology. view more (2007-09-17)
Mouse protein points to memory pill for the old
A drug to aid learning and memory in the elderly may be possible as a result of work being carried out at the Wolfson Institute for Biomedical Research at University College London. A team led by Dr Karl Peter Giese, of the department of learning and memory, is looking at the molecular and cellular mechanisms underlying memory - not so much the... view more... (2000-04-10)
The pen may be mightier than the keyboard
When it comes to writing the pen apparently is mightier than the computer keyboard. Second, fourth and sixth grade children with and without handwriting disabilities were able to write more and faster when using a pen than a keyboard to compose essays, according to new research. view more (2009-09-17)
One secret to how TB sticks with you
Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl. view more (2009-07-10)
Nanotech tools yield DNA transcription breakthrough
Rutgers researcher Richard H. Ebright and his collaborators have resolved key questions regarding transcription, the fundamental life process that was the subject of the 2006 Nobel Prize in Chemistry. view more (2006-11-17)
Conaway Lab Demonstrates Mechanism by which Transcription Factor Controls Gene Expression
The Conaway Lab - led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., Investigators - has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression. Yong Cai, Ph.D., Research Specialist I, and Jingji Jin, Ph.D., Senior Research Associate, are the paper's coequal first authors. view more (2007-08-28)
A simple feedback resistor switch keeps latent HIV from awakening
Upon entering a cell, a virus often becomes dormant, turning off its genes and laying low until awakened by som e trigger from its environment. When that trigger is pulled, the virus quickly ramps up production of proteins through built-in positive-feedback loops that turn up gene transcription. view more (2006-12-26)
miR-196a promotes the metastases of tumors
MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. view more (2009-05-13)
What is the mechanism of the chronic radiation enteritis?
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. view more (2008-12-23)
Suicide Gene Combination Targets Breast Cancer
A new 'mix and match' cancer therapy is being unveiled at the British Endocrine Societies meeting in Birmingham today. view more (2000-03-07)
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