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Location matters, even for genes
Moving an active gene from the interior of the nucleus to its periphery can inactivate that gene report scientists from the University of Chicago Medical Center in an article to be published early online Feb.13, 2008, in the journal Nature. view more (2008-02-14)
Brown Cancer Biologists Identify Major Player in Cell Growth
When cells go about the business of dividing, they can get sidelined. Maybe there aren't enough nutrients. Maybe there aren't the right signals to resume multiplying. Either way, cells go quiet. view more (2007-02-07)
Pol3 mutation disrupts organ growth
The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting. view more (2007-11-27)
Flick of a protein switches immune response
A single protein can turn on and off a key component of the immune system by changing partners in an elegant genomic dance, said researchers at the University of Southern California and Harvard Medical School. view more (2006-07-28)
Cancer researchers found a new mechanism potentially explaining evolution of signalling pathways
Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. view more (2006-02-08)
Protein plays unexpected role protecting chromosome tips
A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell. view more (2009-08-14)
Stem cell breakthrough offers diabetes hope
Scientists have discovered a new technique for turning embryonic stem cells into insulin-producing pancreatic tissue in what could prove a significant breakthrough in the quest to find new treatments for diabetes. view more (2008-04-03)
Revealing the machinery underlying the 'plastic' juvenile brain
Among the central mysteries of neurobiology is what properties of the young brain enable it to so adeptly wire itself to adapt to experience—a quality known as plasticity. view more (2007-03-01)
Prediction of gene function in mammals
Gene function in mammals can be quickly and reliably predicted using a high-throughput analysis of patterns of RNA expression, according to an article published today in Journal of Biology. This challenges the conventional view that tissue-specificity is the best predictor of function, and could speed up the quest to understand whole genomes, in... view more... (2004-12-02)
'Gateway' gene discovered for brain cancer
Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain development also plays a central role in the development of the lethal brain cancer malignant glioma. view more (2007-02-15)
New path from estrogen to survival in breast cancer cells described
After years of research, scientists at The University of Texas M. D. Anderson Cancer Center are now able to explain, in exquisite molecular detail, how the estrogen hormone can help keep breast cancer cells alive. view more (2006-09-26)
Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
Cardiovascular diseases (CVD) are major contributors to morbidity and mortality worldwide. Several interacting environmental, biochemical, and genetic risk factors can increase disease susceptibility. view more (2008-04-08)
Jefferson researchers uncover new way nature turns genes on and off
Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development. view more (2006-12-28)
Learning how the pieces responsible for interpreting the human genome work
The human genome complete sequencing project in 2003 revealed the enormous instruction manual necessary to define a human being. However, there are still many unanswered questions. There are few indications on where the functional elements are found in this manual. view more (2009-04-22)
Mayo Clinic study tackles labeling errors
With a long-held commitment to continuously improving the quality and safety of patient care, Mayo Clinic researchers are recommending a new technologically-advanced labeling system aimed at reducing specimen labeling errors in a high-volume gastrointestinal endoscopy center view more (2008-10-06)
Process controlling T cell growth and production identified
Identifying one of the processes that plays a role in naïve and memory T-cells' growth and production could one day lead to better vaccines and possibly more effective cancer immunotherapy. view more (2009-05-04)
Location, location, location: Transcriptional activity and nuclear position
Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. view more (2006-05-18)
What makes stem cells tick?
Investigators at the Burnham Institute for Medical Research (Burnham) and The Scripps Research Institute (TSRI) have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells (hESCs) and their differentiated derivatives. view more (2009-08-07)
Research Reveals Secrets of Alcohol's Effect on Brain Cells
Alcohol triggers the activation of a variety of genes that can influence the health and activity of brain cells, and new research from Weill Cornell Medical College in New York City sheds light on how that process occurs. view more (2007-12-10)
Pair of microRNA molecules controls major oncogene in most common leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world. view more (2006-12-18)
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