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Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
Effector T cells (Teff cells) are involved in activating and directing other immune cells, while regulatory T cells (Tregs) act to curb the over-aggressive responses of the T cell population. view more (2006-06-16)
Mayo researchers discover mechanism of cell type-specific signaling in tumor development
Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development - factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current online issue of Developmental Cell. view more (2009-04-08)
Skin flaps deliver cancer-fighting therapy, ASPS study reveals
Using gene therapy, plastic surgeons have delivered cancer fighting proteins through skin flaps placed on cancerous tumors on rats with a 79 percent reduction in tumor volume. view more (2008-05-09)
New target for cancer therapy may improve treatment for solid tumors
Targeting and killing the non-malignant cells that surround and support a cancer can stop tumor growth in mice, reports a research team based at the University of Chicago Medical Center in the March 1, 2008, issue of the journal Cancer Research. The discovery offers a new approach to treating cancers that are resistant to standard therapy. view more (2008-03-04)
Analysis of breast and colon cancer genes finds many areas of differences between tumors
Researchers from University Hospitals (UH) Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors. view more (2007-10-12)
T-beta-RIII joins the fight against breast cancer
Although the soluble factor TGF-beta has been shown to suppress the growth of tumor cells in the early stages of breast cancer, high levels of TGF-beta during the later stages of the disease are associated with a poor outcome. view more (2006-12-08)
Breast cancer : Discovery of a new tumor marker
At the Curie Institute in Paris, CNRS researchers have discovered a new proliferation marker : the CAF-1 complex. Since deregulated cell proliferation is one of the most characteristic features of tumor cells, this discovery represents a breakthrough in the cancer field. The researchers from the Curie Institute have already validated the use of... view more... (2004-03-30)
A new therapeutic option for human hepatocyte cancer
p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced oncolytic infections. view more (2008-09-24)
Massive necrosis after trans-catheter treatment is more common in the presence of tumor capsule
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Prognosis of patients with HCC complicating cirrhosis mainly depends on the tumor growth, progression of the underlying liver disease and the effectiveness of antitumoral treatment. view more (2007-11-26)
Post-pregnancy events promote breast tumor metastasis
Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells. view more (2006-02-03)
Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer that spreads elsewhere in the body, known as metastasis, is the process that most often leads to death from the disease. view more (2009-03-30)
Tulane pioneers novel ovarian cancer treatment
The Tulane University Section of Hematology and Medical Oncology is investigating a novel treatment for ovarian cancer by using intravenous Ontak to deplete harmful cells that inhibit the body's natural immune response to fight cancer. Ovarian cancer is the fifth leading cancer killer of women in the United States. view more (2005-07-18)
Study identifies new tumor suppressor
A protein called HLJ1 may work as a novel tumor suppressor in non-small-cell lung carcinoma. view more (2006-06-21)
New insights into the regulation of PTEN tumor suppression function
The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequently mutated of all tumor suppressors. view more (2008-08-21)
U of M researchers discover compounds to shrink tumors
Researchers at the University of Minnesota have developed novel anti-cancer drugs to treat solid tumors. These "small molecules" belong to a class of pharmaceutical agents called anti-angiogenics. view more (2006-07-06)
Fly with brain tumor may shed light on cancer causing genes
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain tumors develop. The causes of brain tumor... view more... (2004-04-14)
Are tumors causing stricture of bile duct always malignant?
The benign biliary tract tumor is rarely found in clinical practice. One case of bile duct adenomyoma was recently reported in the January 28 issue of the World Journal of Gastroenterology. view more (2008-02-22)
Bone drug could help prevent the spread of breast cancer
Maintaining bone density could be a key to decreasing the spread of cancer in women with locally advanced breast cancer, according to research at Washington University School of Medicine in St. Louis. view more (2008-05-19)
MicroRNA-mediated metastasis suppression
Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis. view more (2009-10-29)
Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer
A decades-old cancer mystery has been solved by researchers at Cold Spring Harbor Laboratory (CSHL). "We not only found a critical tumor suppressor gene, but have revealed a master switch for a tumor suppressive network that means more targeted and effective cancer therapy in the future," said CSHL Associate Professor Alea Mills, Ph.D.... view more... (2007-02-12)
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