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U-M researchers link pathway to breast cancer stem cells
A gene well known to stop or suppress cancer plays a role in cancer stem cells, according to a new study from the University of Michigan Comprehensive Cancer Center. The researchers found that several pathways linked to the gene, called PTEN, also affected the growth of breast cancer stem cells. view more (2009-06-02)
Urologist plays key role in determining use of hormone therapy in prostate cancer
The urologist a patient sees may be a more important factor than the tumor characteristics or the patient's other characteristics in determining the use of hormonal therapy for prostate cancer. view more (2006-06-21)
Obesity drug helps unlock clues about cancer
An approved drug for fighting obesity is helping scientists at Wake Forest University School of Medicine uncover clues about how to stop the growth of cancerous tumors. view more (2007-02-02)
Breast Cancer, Prognostic Factors, Mortality, Recurrence
Tumor Grade, Age at Diagnosis of First Tumor, and Duration Without Cancer Predict the Risk of Death After a Local Recurrence of Breast Cancer view more (2002-05-16)
Trojan horse for ovarian cancer -- nanoparticles turn immune system soldiers against tumor cells
In a feat of trickery, Dartmouth Medical School immunologists have devised a Trojan horse to help overcome ovarian cancer, unleashing a surprise killer in the surroundings of a hard-to-treat tumor. view more (2009-07-16)
Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
Portal venous tumor thrombus (PVTT) is a crucial factor that can worsen the prognosis of patients with hepatocellular carcinoma (HCC). view more (2007-10-18)
Rheb's role in cancer
Two independent papers in the August 15th issue of G&D identify the Rheb GTPase as a novel oncogene and a promising new chemotherapeutic target. view more (2008-08-15)
Researchers identify genes that allow brain cancer-causing stem cells to resist treatment
While great interest has followed the discovery of neural stem cells and their potential for someday treating diseases and injuries of the brain and spinal cord, recent research identified "cancer stem cells," a small population of cells that appear to be the source of cells comprising a malignant brain tumor. view more (2006-12-18)
New pathway could present an intervention point for cancer treatment
A new cellular pathway leads to destruction of a protein that promotes growth of breast, prostate and similar cancers and could provide a new avenue through which to pursue treatment of such diseases. view more (2006-01-27)
Genes set scene for metastasis
Biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor. view more (2007-04-12)
Surgery not necessary for most late-stage colorectal cancers
A new study shows that a large majority of patients who present with advanced colorectal cancer that has spread to other organs (stage IV) don't require immediate surgery to remove the primary tumor in the colon. view more (2009-06-01)
Researchers at Vanderbilt-Ingram Cancer Center uncover clue to explain invasive brain tumors
Researchers at the Vanderbilt-Ingram Cancer Center have uncovered a clue to explain the invasive nature of an aggressive kind of brain tumor called glioblastoma multiforme, or gliomas. view more (2006-01-12)
Antitumor agent under the microscope
Mechanical stabilization of DNA keeps tumor cells in check Cisplatin is one of the most widely employed cancer medications. As with many other chemotherapy agents, the mechanism by which it works has not been fully researched. Now, thanks to Munich physicists Hermann E. Gaub, Rupert Krautbauer, and Hauke Clausen-Schaumann, an important step toward... view more... (2000-10-30)
Pharmaceutical market fails pregnant women; and more
In a clinical trial published this week in PLoS Medicine, Charles Sawyers and colleagues looked at the safety of a drug called rapamycin in a selected group of patients who were undergoingsurgery after recurrence of glioblastoma (a highly malignant tumor of the brain). view more (2008-01-22)
A novel mechanism of action for anti-tumor agent, CA4P
Anti-angiogenic agents have been successful in the clinic for blocking the growth of solid tumors. However, these agents used in combination with chemotherapy have improved the survival of patients with cancers by only several months. view more (2005-10-07)
What is the influence of tumor removal on the serum level of carbohydrate's antibody?
Cancer immune surveillance is considered to be important in the anti-tumor protection of the host. The growing tumor escapes the immune control under the immunosuppressive conditions. view more (2008-10-08)
Gliomas exploit immune cells of the brain for rapid expansion
Gliomas are among the most common and most malignant brain tumors. These tumors infiltrate normal brain tissue and grow very rapidly. As a result, surgery can never completely remove the tumor. view more (2009-07-17)
RNA splicing factor implicated in ovarian tumor cell growth
An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago. view more (2007-04-10)
Nanoparticles + light = dead tumor cells
Medical physicists at the University of Virginia have created a novel way to kill tumor cells using nanoparticles and light. view more (2008-07-30)
A fisheye view of the deadliest breast cancer
Inflammatory breast cancer (IBC) is the deadliest form of the disease, with fewer than half of those diagnosed today having a five-year prognosis for survival. view more (2006-12-13)
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