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Children's National researchers develop novel anti-tumor vaccine
A novel anti-tumor vaccine for neuroblastoma and melanoma developed by scientists and clinicians at Children's National Medical Center in collaboration with investigators from the University of Iowa is showing significant impact on tumor growth in mice.   view more (2008-10-03)

Tiny tool to control growing blood vessels opens new potential in tumor research
Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels.   view more (2009-02-23)

USC researchers develop new drug to target tumor cells and blood vessels
Researchers at the University of Southern California have identified a new drug compound that appears to target tumor cells and surrounding blood vessels without the negative side effects typically associated with Cox-2 inhibitors.   view more (2009-04-20)

Estrogen-Dependent Switch Tempers Killing Activity of Immune Cells
The sex hormone estrogen tempers the killing activity of a specific group of immune cells, the cytotoxic T cells (CTLs), which are known to attack tumor cells and cells infected by viruses.   view more (2009-08-10)

Combination therapy reduces tumor resistance to radiation
Radiation is used to treat a variety of tumors and the response of tumors to radiation is dependent on endothelial cell death, which in turn limits oxygen delivery to the tumor, causing hypoxia and tumor cell death.   view more (2007-06-08)

New target for cancer therapy may improve treatment for solid tumors
Targeting and killing the non-malignant cells that surround and support a cancer can stop tumor growth in mice, reports a research team based at the University of Chicago Medical Center in the March 1, 2008, issue of the journal Cancer Research. The discovery offers a new approach to treating cancers that are resistant to standard therapy.   view more (2008-03-04)

A new therapeutic option for human hepatocyte cancer
p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced oncolytic infections.   view more (2008-09-24)

Fluorescent cancer cells to guide brain surgeons
Gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. Gliomas are often resistant to chemotherapy.   view more (2009-04-06)

Mayo researchers discover mechanism of cell type-specific signaling in tumor development
Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development - factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current online issue of Developmental Cell.   view more (2009-04-08)

Study links nicotine with breast cancer growth and spread
A study published in Cancer Research, a journal of the American Association for Cancer Research, suggests a possible role for nicotine in breast tumor development and metastases.   view more (2008-10-15)

Tulane pioneers novel ovarian cancer treatment
The Tulane University Section of Hematology and Medical Oncology is investigating a novel treatment for ovarian cancer by using intravenous Ontak to deplete harmful cells that inhibit the body's natural immune response to fight cancer. Ovarian cancer is the fifth leading cancer killer of women in the United States.   view more (2005-07-18)

Study provides documentation that tumor 'stem-like cells' exist in benign tumors
Cancer stem-like cells have been implicated in the genesis of a variety of malignant cancers. Research scientists at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute have isolated stem-like cells in benign (pituitary) tumors and used these "mother" cells to generate new tumors in laboratory mice.   view more (2009-07-23)

T-beta-RIII joins the fight against breast cancer
Although the soluble factor TGF-beta has been shown to suppress the growth of tumor cells in the early stages of breast cancer, high levels of TGF-beta during the later stages of the disease are associated with a poor outcome.   view more (2006-12-08)

Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer that spreads elsewhere in the body, known as metastasis, is the process that most often leads to death from the disease.   view more (2009-03-30)

Genes set scene for metastasis
Biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor.   view more (2007-04-12)

A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value.   view more (2008-05-21)

Breast cancer : Discovery of a new tumor marker
At the Curie Institute in Paris, CNRS researchers have discovered a new proliferation marker : the CAF-1 complex. Since deregulated cell proliferation is one of the most characteristic features of tumor cells, this discovery represents a breakthrough in the cancer field. The researchers from the Curie Institute have already validated the use of... view more... (2004-03-30)

Tumor suppressor gene in flies may provide insights for human brain tumors
In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and become a brain tumor.   view more (2009-06-23)

Experimental anti-cancer synthetic molecule targets tumor cell growth and angiogenesis
A recent study conducted by three French CNRS (Centre National de la Recherche Scientifique) laboratories describes a new candidate anti-cancer drug, named HB-19.   view more (2008-06-18)

New Notre Dame study provides insights into the molecular basis of tumor cell behavior
A new study by a team of researchers led by Crislyn D'Souza-Schorey, associate professor of biological sciences at the University of Notre Dame, sheds light on the molecular basis by which tumor cells modulate their surroundings to favor cancer progression.   view more (2009-11-06)
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