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Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
Attaching a recently discovered cytokine to neural stem cells derived from bone marrow, researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute have developed a tool to track and kill malignant brain tumor cells and provide long-term protection against their return.   view more (2006-03-01)

New technique detects early metastasis of breast cancer
In the U.S., a novel technology soon may be available to detect the spread, or metastasis, of breast cancer earlier than now possible, according to research presented at the first international meeting on Molecular Diagnostics in Cancer Therapeutic Development.   view more (2006-09-14)

Stopping the clock: Genetics of tumor latency in skin cancer
Dr. Anthony E. Oro and colleagues (Stanford University) have identified two key Gli protein degradation signals that directly affect tumor latency in a mouse model of human skin cancer.   view more (2006-01-20)

Science researchers genetically transform immune cells into tumor fighters
A team of researchers has genetically engineered normal immune cells to become specialized tumor fighters, demonstrating for the first time that these engineered cells can persist in the body and shrink large tumors in humans.   view more (2006-09-01)

Cancer-killing viruses influence tumor blood-vessel growth
Viruses genetically designed to kill cancer cells offer a promising strategy for treating incurable brain tumors such as glioblastoma, but the body's natural defenses often eliminate the viruses before they can eliminate the tumor.   view more (2008-06-11)

Potential diagnostic marker indicates effectiveness of anti-angiogenic drugs
If an anti-angiogenic drug is successfully starving a cancer patient's tumor to death, the number of endothelial cells circulating in the individual's bloodstream will decrease, thus providing a potential biomarker for gauging the medication's effectiveness.   view more (2006-09-18)

To evade chemotherapy, some cancer cells mimic stem cells
Anti-cancer treatments often effectively shrink the size of tumors, but some might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease, according to findings presented today in Atlanta, Georgia at the American Association for Cancer... view more (2007-09-20)

New Cancer Gene Discovered
Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears Monday in Nature's cancer journal Oncogene.   view more (2008-05-09)

Cancer stem cells can go it alone
At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them.   view more (2007-06-12)

Freezing kidney tumors is a safe alternative to surgery
Percutaneous cryoablation, a relatively non-invasive technique that destroys tumors by freezing them, is a safe method for treating kidney tumors in selected patients who are not considered candidates for surgery, according to a new study by researchers from the Mayo Clinic in Rochester, MN.   view more (2006-05-01)

Antitumor agent under the microscope
Mechanical stabilization of DNA keeps tumor cells in check Cisplatin is one of the most widely employed cancer medications. As with many other chemotherapy agents, the mechanism by which it works has not been fully researched. Now, thanks to Munich physicists Hermann E. Gaub, Rupert Krautbauer, and... view more (2000-10-30)

Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
A nanoparticle drug delivery system designed for brain tumor therapy has shown promising tumor cell selectivity in a novel cell culture model devised by University of Nottingham scientists.   view more (2007-08-23)

Scripps research scientists show protein accelerates breast cancer progression in animal models
These new findings could lead to a better understanding of the molecular pathogenesis of breast cancer and focus attention on PTN and its signaling pathway as possible targets for new cancer therapies.   view more (2007-06-21)

Researchers find way to make tumor cells easier to destroy
Tumors have a unique vulnerability that can be exploited to make them more sensitive to heat and radiation, researchers at Washington University School of Medicine in St. Louis report.   view more (2008-05-07)

CSHL scientists identify and repress breast cancer stem cells in mouse tissue
By manipulating highly specific gene-regulating molecules called microRNAs, scientists at Cold Spring Harbor Laboratory (CSHL) report that they have succeeded in singling out and repressing stem-like cells in mouse breast tissue - cells that are widely thought to give rise to cancer.   view more (2007-12-18)

Drawing a crowd: How progenitor cells are recruited to tumor blood vessels from the bone marrow
Cells within the bone marrow (progenitor cells) that express a protein called CD34 have been shown to leave the marrow and travel to sites of tissue injury to mediate repair.   view more (2006-02-24)

Enhanced DNA-repair mechanism can cause breast cancer
Although defects in the "breast cancer gene," BRCA1, have been known for years to increase the risk for breast cancer, exactly how it can lead to tumor growth has remained a mystery.   view more (2007-10-15)

Vitamin A pushes breast cancer to form blood vessel cells
Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply,... view more (2008-07-16)

Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics.   view more (2008-02-15)

Ingredient Found In Green Tea Significantly Inhibits Breast Cancer Growth In Female Mice
Green tea is high in the antioxidant EGCG (epigallocatechin-3- gallate) which helps prevent the body's cells from becoming damaged and prematurely aged.   view more (2008-04-08)

Malignant melanoma cells secrete protein required for embryo formation
A Northwestern University research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to proper embryo formation.   view more (2006-07-31)

Clinical trial evaluating brain cancer vaccine is underway at NYU
A clinical trial evaluating a brain cancer vaccine in patients with newly diagnosed brain cancer has begun at NYU Medical Center.   view more (2007-10-22)

Normalizing tumor vessels to improve cancer therapy
Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal-"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at... view more (2008-08-26)

New inhibitor has potential as cancer drug
Laboratory experiments have previously shown that cancer cells overproduce an enzyme, heparanase, which splits the body's own polysaccharide heparan sulfate into shorter fragments.   view more (2007-10-23)

MIT IDs link between brain tumor proteins
MIT researchers have identified a critical link between two proteins found in brain tumors, a discovery that could eventually help treat a form of brain cancer that kills 99 percent of patients.   view more (2007-07-20)
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