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Animal Study Identifies Promising New Target for Brain Tumor Therapy
A drug that targets the body's immune cells may be effective in treating malignant brain tumors, according to a new study led by researchers at Duke's Preston Robert Tisch Brain Tumor Center. In animal models, the drug re-engaged the body's cancer-damaged immune system.   view more (2007-05-09)

Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
Cell biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have provided further evidence that a gene thought to play a role in suppressing tumors actually can protect against the development of pre-cancerous cell growth as well.   view more (2006-11-02)

MGH Cancer Center researchers find new gene associated with Wilms tumor
Researchers at the Massachusetts General Hospital (MGH) Cancer Center have discovered a novel gene mutation associated with Wilms tumor, the most common pediatric kidney cancer.   view more (2007-01-05)

Nanoparticles carry chemotherapy drug deeper into solid tumors
A new drug delivery method using nano-sized molecules to carry the chemotherapy drug doxorubicin to tumors improves the effectiveness of the drug in mice and increases their survival time.   view more (2007-06-27)

Head and neck cancer vaccine targets proteins to create immune response
Most attempts to create therapeutic cancer vaccines are based on custom-made approaches that use a patient's own tumor cells to generate a strong immune response against cancer. However, developing these kinds of personalized vaccines is time-consuming, expensive and often impractical.   view more (2007-04-18)

St. Jude study shows temporary improvement of tumor blood flow can improve chemotherapy
A treatment for neuroblastoma that lands a one-two punch works best when the second punch is timed to take maximum advantage of the first one, according to results of studies at St. Jude Children's Research Hospital.   view more (2007-07-12)

Treatment-induced growth factor causes cancer progression
In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment.   view more (2007-04-06)

'Clumping' protein linked to return of ovarian cancer
Johns Hopkins scientists have discovered that women treated for ovarian cancer are at increased risk of a rapid and potentially fatal recurrence if their tumor cells have high levels of a binding protein that triggers abnormal growth and slows down cell death, both hallmarks of malignancy.   view more (2006-12-18)

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
A molecular "off" switch packaged in a tiny sphere penetrates deeply into ovarian cancer tumor cells, stifling a troublesome protein and drastically reducing the size of tumors.   view more (2006-08-15)

Test helps identify patients with breast cancer who will likely benefit from chemotherapy
A test that measures the amounts of two members of the same protein family-one of which appears to act as an oncogene, and the other as a tumor suppressor-helps identify patients with breast cancer who will likely benefit from chemotherapy and those who won't, according to researchers.   view more (2006-09-18)

Blocking one protein helps cancer cells die of natural causes
Researchers have identified a protein fragment that keeps at least one major tumor suppressor gene from preventing cancer like it should. The fragment belongs to a class of proteins known as apoptotic enhancers (ASPP), named for their ability to stimulate programmed cell death, or apoptosis, by the... view more (2003-01-08)

BC biologists identify alternative brain cancer treatment
Boston College biologists have identified an alternative, diet-based method of treating brain cancer that does not involve administering toxic chemicals, radiation or invasive surgery.   view more (2007-02-21)

Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates.   view more (2007-04-30)

Skin flaps deliver cancer-fighting therapy, ASPS study reveals
Using gene therapy, plastic surgeons have delivered cancer fighting proteins through skin flaps placed on cancerous tumors on rats with a 79 percent reduction in tumor volume.   view more (2008-05-09)

Flow technique could simplify targeting cancer therapy
A quick and simple technique to characterize breast cancer cells may expedite and improve treatment decisions, researchers from the University of Illinois at Chicago report in the journal of Experimental and Molecular Pathology.   view more (2006-02-02)

Change in gene may be underlying molecular defect in some colorectal cancers, study suggests
Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer.   view more (2005-09-21)

UM researchers find new marker to identify cancer stem cells
Researchers at the University of Michigan Comprehensive Cancer Center have found a marker that can be used to identify stem cells in breast tumors, suggesting a potential simple test that could help determine the best treatment for breast cancer.   view more (2007-12-04)

Drug attacks prostate cancer in mouse model by destroying its blood supply
A medication used to treat other types of cancer strangles drug-resistant, metastatic prostate cancer by cutting off its blood supply.   view more (2006-06-07)

Brain tumor researchers find their 'niche'
Brain tumors appear to arise from cancer stem cells (CSCs) that live within microscopic protective "niches" formed by blood vessels in the brain; and disrupting these niches is a promising strategy for eliminating the tumors and preventing them from re-growing.   view more (2007-01-17)

Novel marker of colon cancer
Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide.   view more (2008-10-24)

Oncoproteins double-team and destroy vital tumor-suppressor
Two previously unconnected cancer-promoting proteins team up to ambush a critical tumor suppressor by evicting it from the cell's nucleus and then marking it for death by a protein-shredding mechanism, a team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the... view more (2008-02-15)

Promising new methods of treatment for fatal abdominal tumor
GIST is a soft-parts tumor that occurs in the abdomen but is distinguishable from gastro-intestinal cancer. Previously, surgery has been the only treatment option since this type of tumor does not respond to either chemotherapy or radiation. Scientists at the Sahlgrenska Academy at Göteborg... view more (2003-03-17)

'Destruct' triggers may be jammed in tumor cells, UF geneticists say
Tumor cells living in the cross hairs of radiation or chemotherapy may be able to escape death because their self-destruct mechanisms are jammed, say University of Florida scientists writing in a recent issue of Developmental Cell.   view more (2008-05-01)

New insights into the regulation of PTEN tumor suppression function
The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequently mutated... view more (2008-08-21)

Combined treatment extends life expectancy for lung cancer patients
Combining thermal ablation with radiation therapy extends average life expectancy and decreases recurrences of tumors in patients who have early stages of inoperable lung cancer, according to researchers at Rhode Island Hospital.   view more (2006-07-17)
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