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Brain tumor researchers find their 'niche'
Brain tumors appear to arise from cancer stem cells (CSCs) that live within microscopic protective "niches" formed by blood vessels in the brain; and disrupting these niches is a promising strategy for eliminating the tumors and preventing them from re-growing. view more (2007-01-17)
Cancer therapy: A role for MAPK inhibitors combined with mTORC1 inhibitors
Nearly a decade ago, while it was being tested as an immunosuppressive agent to prevent organ rejection in transplant patients, the drug rapamycin was also discovered to have anti-tumor properties. Since then, several rapamycin analogs known as mTOR (mammalian target of rapamycin) inhibitors have been tested in clinical trials for the treatment of... view more... (2008-08-22)
Unique estrogen receptor linked to metastatic breast cancer
Breast cancer awareness month may have passed, but researchers remain focused on the disease with a new study showing that a unique estrogen receptor found in breast cancer tumors is a predictor of tumor size and metastases. view more (2006-11-01)
Cancer: Another step towards medication
The gene Myc is an important factor for the growth of organisms by cell division. It causes the production of a protein which, as a transcription factor, controls the expression of up to 15 % of all human genes. view more (2009-03-18)
Research uncovers clues to virus-cancer link
In a series of recently-published articles, a research team from the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center has uncovered clues to the development of cancers in AIDS patients. view more (2009-06-18)
Interesting lead in the treatment of Ewing`s sarcoma
Research scientists at INSERM, CNRS and the Institut Curie, in collaboration with physicians, have used a mouse model to demonstrate the efficacy of an innovative therapeutic approach to Ewing`s sarcoma: the combination of human interferon (alpha or beta) and a common anti-tumor agent, ifosfamide. Their results were published in the November 2002... view more... (2002-10-31)
Barrow study identifies new way to biopsy brain tumors in real time
A new miniature, hand-held microscope may allow more precise removal of brain tumors and an easier recognition of tumor locations during surgery. view more (2009-11-12)
SEK 20 million for brain tumor research
The M'Īrit and Hans Rausing Charitable Foundation in England has awarded SEK 20 million over five years to a research team at the Faculty of Medicine at Lund University in Sweden. The team is conducting the so-called BRIGTT Project (BRain Immuno Gene Tumor Therapy), which is pursuing laboratory work and clinical research to try to find new methods... view more... (2003-06-25)
Inhibiting cell process may give cancer drug a boost
A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug. view more (2006-05-04)
UAB Study Shows Drug May Fight Biliary Cancers
Laboratory studies by University of Alabama at Birmingham (UAB) researchers have shown that the drug triphendiol (NV-196) causes cell death in pancreatic and bile duct cancer cell lines, slows tumor growth and sensitizes tumors to chemotherapy treatments. view more (2008-04-16)
Skin flaps deliver cancer-fighting therapy, ASPS study reveals
Using gene therapy, plastic surgeons have delivered cancer fighting proteins through skin flaps placed on cancerous tumors on rats with a 79 percent reduction in tumor volume. view more (2008-05-09)
Ewing's sarcoma : Discovery of a "link" in tumor growth
To develop new therapeutic approaches to cancer, it is essential to understand the long and extremely complex process that underlies it, in other words the various stages of cancer development from the initial mutation to the tumor. Having already identified the alteration that leads to Ewing's sarcoma, a bone cancer which afflicts young people,... view more... (2004-09-23)
Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors
Transplanted embryonic stem cells are recognized as a potential treatment for patients suffering from the effects of spinal cord injury (SCI). view more (2009-05-12)
Tissue stiffness drives tumor formation
The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness. view more (2005-09-23)
New insights into the regulation of PTEN tumor suppression function
The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequently mutated of all tumor suppressors. view more (2008-08-21)
How can we know early who will benefit from tumor target therapy?
The precise tailoring of tumor target treatment for patients with cancer is an unmet challenge. The goal is to only administer treatments that have a high probability of being effective. view more (2007-11-26)
Vitamin A pushes breast cancer to form blood vessel cells
Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumor growth. view more (2008-07-16)
Inhibition of iron-metabolizing enzyme reduces tumor growth
A report in the Journal of Biological Chemistry shows that inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduces Kaposi sarcoma tumor growth. view more (2006-04-21)
Trojan horse for ovarian cancer -- nanoparticles turn immune system soldiers against tumor cells
In a feat of trickery, Dartmouth Medical School immunologists have devised a Trojan horse to help overcome ovarian cancer, unleashing a surprise killer in the surroundings of a hard-to-treat tumor. view more (2009-07-16)
Gene therapy completely suppresses ovarian cancer growth in animal model
University of Pittsburgh School of Medicine researchers have used gene therapy to either completely abolish or significantly inhibit tumor progression in a mouse model of ovarian cancer. view more (2006-06-05)
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