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Test helps identify patients with breast cancer who will likely benefit from chemotherapy
A test that measures the amounts of two members of the same protein family-one of which appears to act as an oncogene, and the other as a tumor suppressor-helps identify patients with breast cancer who will likely benefit from chemotherapy and those who won't, according to researchers. view more (2006-09-18)
Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team
Researchers with the University of Pennsylvania School of Veterinary Medicine have demonstrated the process by which the cancer-causing chemical dioxin attacks the cellular machinery, disrupts normal cellular function and ultimately promotes tumor progression. view more (2007-12-18)
Cancer drugs my build and not tear down blood vessels
Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth - a process called angiogenesis - was by creating drugs aimed at stopping a key vessel growth-promoting protein. But now the opposite seems to be true. view more (2008-11-10)
Scientists discover anti-cancer mechanism that arrests early prostate cancer
Prostate cancer, the second leading cause of cancer death for men in the United States, is caused by changes in several tummor suppressor genes including PTEN and p53. view more (2005-08-04)
Tumor wizardry wards off attacks from the immune system
Like the fictional wizard Harry Potter, some cancerous tumors seem capable of wrapping themselves in an invisibility cloak. Researchers at Washington University School of Medicine in St. Louis have found that pancreatic tumors hide from the body's immune surveillance by surrounding themselves with cells that make it hard for the immune system to... view more... (2006-07-17)
UNC scientists identify growth factor as possible cancer drug target
To grow and spread, tumors need new blood vessels, a process called angiogenesis. view more (2009-06-10)
OHSU Cancer Institute researchers find connection between protein, prognosis in breast cancer
Oregon Health & Science University Cancer Institute researchers have found that a tumor protein present in an aggressive form of breast cancer is related to a poor prognosis. view more (2008-04-14)
Genes set scene for metastasis
Biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor. view more (2007-04-12)
Identifying the potential for tamoxifen resistance in patients
Tamoxifen is a widely used and highly successful drug in the treatment of breast cancer, though resistance to tamoxifen is still a concern in recurrent disease (affecting 25-35% of patients), since therapy resistant metastatic tumor cells are a major cause of death. view more (2009-06-11)
Flavonoids may inhibit prostate cancer
Previous studies have suggested that increased intake of flavonoids which are common in fruits and vegetables may be associated with a reduced risk of prostate cancer. view more (2005-10-21)
Researchers safely regenerate failing mouse hearts with programmed embryonic stem cells
Mayo Clinic researchers have safely transplanted cardiac preprogrammed embryonic stem cells into diseased hearts of mice successfully regenerating infarcted heart muscle without precipitating the growth of a cancerous tumor — which, so far, has impeded successful translation into practice of embryonic stem cell research. view more (2007-02-28)
Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates. view more (2007-04-30)
Colon cancer a disease of hormone deficiency, Jefferson team finds
Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have found new evidence suggesting that colon cancer is actually a disease of missing hormones that could potentially be treated by hormone replacement therapy. view more (2007-08-01)
Jefferson researchers uncover new evidence of prolactin's possible role in breast cancer
Scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the hormone prolactin in breast cancer. view more (2007-10-01)
A new mathematical formula for cancer progression
Tumor progression can now be mapped less to mathematical standards and more to individual patients according to a new study by researchers at Harvard and Johns Hopkins Universities. view more (2007-11-09)
New insight into the genetics of brain tumor formation
In a G&D paper published online ahead of its April 1 print publication date, Dr. William Kaelin (Dana Farber Cancer Institute) and colleagues identify a potential new neuronal tumor suppressor. view more (2008-03-18)
Studies find possible drug targets for improving vascular health
The enzyme nitric oxide synthase plays a role in peripheral vascular disease, a common disease that impairs the mobility of 25 percent of people over the age of 50, according to a Yale study in the Proceedings of the National Academy of Sciences (PNAS). view more (2005-08-26)
Bone drug could help prevent the spread of breast cancer
Maintaining bone density could be a key to decreasing the spread of cancer in women with locally advanced breast cancer, according to research at Washington University School of Medicine in St. Louis. view more (2008-05-19)
First noninvasive technique to accurately predict mutations in human brain tumors
Donald O'Rourke, MD, Associate Professor of Neurosurgery at the University of Pennsylvania School of Medicine and colleagues, were able to accurately predict the specific genetic mutation that caused brain cancer in a group of patients studied using magnetic resonance imaging (MRI). view more (2009-04-21)
Researchers Discover Method in Mice to Restore Tamoxifen Sensitivity in Resistant Breast Cancer
The widely used breast cancer drug tamoxifen (Nolvadex®), which can become less effective over time, might retain its full strength indefinitely if used along with a second drug, according to new research in mice conducted by investigators from the National Cancer Institute (NCI), part of the National Institutes of Health, and their partners. view more (2006-12-21)
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