Tumor Suppressor Current Events | Tumor Suppressor News | 3
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Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates. view more (2007-04-30)
Reversing effects of altered enzyme may fight brain tumor growth
An international team of scientists from the Moores Cancer Center at the University of California, San Diego, the University of North Carolina and several institutions in China have explained how a gene alteration can lead to the development of a type of brain cancer, and they have identified a compound that could staunch the cancer's growth. view more (2009-04-14)
Mayo Clinic Researchers Find Experimental Therapy Turns on Tumor Suppressor Gene in Cancer Cells
Researchers at Mayo Clinic have found that the experimental drug they are testing to treat a deadly form of thyroid cancer turns on a powerful tumor suppressor capable of halting cell growth. Few other cancer drugs have this property, they say. view more (2009-01-20)
Growth factor signals influence balance between normal growth and cancerous growth
New research from The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine deepens the understanding of how the growth hormone/IGF system is affected by another important actor: p53, the tumor suppressor gene that puts the brakes on cancer. view more (2006-11-10)
Novel regulation of the common tumor suppressor PTEN
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon, and brain. view more (2007-01-12)
Novel marker of colon cancer
Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide. view more (2008-10-24)
Fly with brain tumor may shed light on cancer causing genes
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain tumors develop. The causes of brain tumor... view more... (2004-04-14)
Researchers find how a common genetic mutation makes cancer radiation resistant
Many cancerous tumors possess a genetic mutation that disables a tumor suppressor called PTEN. Now researchers at Washington University School of Medicine in St. Louis have shown why inactivation of PTEN allows tumors to resist radiation therapy. view more (2009-06-10)
International research team identifies gene that promotes prostate cancer
Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth. The method enabled the discovery of a new cancer gene, which, when damaged, may promote prostate cancer.... view more... (2004-11-24)
Tumor suppressor pulls double shift as reprogramming watchdog
A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as "guardian of the genome", not only stops cells that could become cancerous in their tracks but also controls somatic cell reprogramming. view more (2009-08-10)
CSHL scientists trace causal link between a tumor suppressor gene and liver cancer
Scientists at Cold Spring Harbor Laboratory (CSHL) have taken the search for cancer-causing genes an important step forward. In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipitates events culminating in an aggressive type of... view more... (2008-06-04)
Cellular molecule spurs growth of prostate cancer
University of North Carolina at Chapel Hill scientists have identified a molecule that stimulates the aggressive growth of prostate cancer. view more (2005-11-29)
A surprise 'spark' for pre-cancerous colon polyps
Researchers at Huntsman Cancer Institute (HCI) at the University of Utah studied the events leading to colon cancer and found that an unexpected protein serves as the "spark" that triggers formation of colon polyps, the precursors to cancerous tumors. view more (2009-05-15)
New journal shows half-broken gene is enough to cause cancer
Tumour suppressor genes do not necessarily require both alleles to be knocked out before disease phenotypes are expressed. Research published in BioMed Central's new open access journal PathoGenetics reveals that only one allele of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal cancer. view more (2008-11-04)
How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
Many hepatocellular carcinoma (HCC) patients in China may be treated with Traditional Chinese medicine (TCM). Some say it works, others doubt its effectiveness. These stated that a research group in China had found TCM can down-regulate the expression of PTEN in HCC, which may suppress tumor cell growth and regulate tumor cell invasion and... view more... (2008-01-17)
Yale scientists show that a microRNA can reduce lung cancer growth
A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle. view more (2008-03-24)
Tumor cells evade death through autophagy
Autophagy is a cellular process that enables cells to turnover their contents, something that they do frequently. Autophagy is initiated in tumor cells by chemotherapy and radiation, but it is not known if this contributes to tumor cell death or helps tumor cells survive the anti-cancer therapy. view more (2007-01-19)
Cancer related gene p53 not regulated as indicated by previous tissue culture research
The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppressor gene. view more (2005-06-28)
MicroRNAs Can Be Tumor Suppressors
University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies. view more (2007-04-26)
KEAP1 Keeps major cancer-promoting protein at bay
A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell. view more (2009-10-12)
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