Tumor Suppressor Current Events | Tumor Suppressor News | 5
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DNA methylation shown to promote development of colon tumors
Damaged or defective genes have long been known to be the cause of some cancers. Over the past decade, however, scientists have discovered that even healthy genes can be switched on or off and can cause cancer without any changes in the underlying DNA sequence-although how this happens has remained poorly understood. view more (2007-12-03)
New investigational treatment for bladder cancer, identified with Columbia-developed research model
A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer. view more (2009-03-13)
Jefferson scientists discover a key protein regulator of inflammation and cell death
Reporting in the journal Nature, researchers led by Emad Alnemri, Ph.D., professor of Biochemistry and Molecular Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation. view more (2009-01-23)
Profiling of cancer genes may lead to better and earlier detection
A research team at UT Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human cancers - lung, breast, prostate and colon cancer. view more (2006-12-27)
Gene dose affects tumor growth
Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model. view more (2008-01-04)
Scientists discover anti-cancer mechanism that arrests early prostate cancer
Prostate cancer, the second leading cause of cancer death for men in the United States, is caused by changes in several tummor suppressor genes including PTEN and p53. view more (2005-08-04)
Researchers uncover new mechanism of tumor suppressor
Researchers from the University of Colorado-Denver and Health Sciences Center and Stanford University have discovered a molecular mechanism that explains how cells respond to DNA damage and other acute stresses, and if disrupted can cause cancer. view more (2006-05-22)
Novel model of osteosarcoma
In the June 15th issue of G&D, Dr. Stuart Orkin (HHMI, Dana-Farber Cancer Institute, Children's Hospital Boston) and colleagues present a new mouse model of osteosarcoma. view more (2008-06-16)
Dual gene therapy suppresses lung cancer in preclinical test
Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice. view more (2007-01-15)
Tumor wizardry wards off attacks from the immune system
Like the fictional wizard Harry Potter, some cancerous tumors seem capable of wrapping themselves in an invisibility cloak. Researchers at Washington University School of Medicine in St. Louis have found that pancreatic tumors hide from the body's immune surveillance by surrounding themselves with cells that make it hard for the immune system to... view more... (2006-07-17)
MIT sheds light on how tumor cells form
MIT cancer researchers have discovered a process that may explain how some tumor cells form, a discovery that could one day lead to new therapies that prevent defective cells from growing and spreading. view more (2006-06-22)
Gene first linked to rare disease may trigger skin cancer, other tumors
A gene first identified in connection with a rare disease in which patients develop multiple, benign skin tumors may be a more general player in cancers found throughout the body. view more (2006-05-19)
A genetic factor predicts prognosis in brain tumor patients
PLoS ONE has just published a study which defines a gene locus on chromosome 1 that predicts prognosis of brain tumor patients and may even set the basis for the development of more efficient drugs to combat brain cancer. view more (2007-06-28)
UCSD researchers discover variants of natural tumor suppressor
Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now identified two variants of that enzyme which could provide new targets for therapies to treat diabetes, heart and neurological disease. view more (2007-04-10)
Pathway links inflammation, angiogenesis and breast cancer
A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells. view more (2007-08-10)
Rare cancer-causing syndrome found, for the first time, in Singapore
A rare hereditary disorder that strongly predisposes carriers to develop cancer at an early age has been found in an Asian female, report researchers today at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine. view more (2007-11-05)
Brain tumors may originate with neural stem cells, researchers say
Researchers at UT Southwestern Medical Center have determined that stem cells in a certain region of the brain may be the source of a particular type of incurable brain tumor and may be implicated in other types of brain cancers as well. view more (2005-08-16)
Small molecule derived from Rb2/p130 could act as cancer therapeutic
A small molecule derived from the spacer domain of the tumor-suppressor gene Rb2/p130 has demonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer therapeutic, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine. view more (2007-03-21)
Novel 'on-off switch' mechanism stops cancer in its tracks
A tiny bit of genetic material with no previously known function may hold the key to stopping the spread of cancer, researchers at Yale School of Medicine and Sichuan University in Chengdu, China report in two papers in the September 7-11 issue of Proceedings of the National Academy of Sciences. view more (2009-09-24)
Pancreatic cancer vaccine halts progression of disease in some patients
A dendritic cell-based therapeutic vaccine for pancreatic cancer developed by researchers at the University of Pittsburgh School of Medicine has successfully stalled the disease from progressing in a handful of patients three years post-vaccination. view more (2007-04-18)
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