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Three new lung tumor subtypes identified in DNA profiling study
A new study has identified three subtypes of non-small-cell lung cancer tumors, a finding that may provide valuable clinical information about patient survival in early- or late-stage disease, how likely the cancer is to spread and whether the tumor will prove resistant to chemotherapy. view more (2006-10-31)
Malignant melanoma cells secrete protein required for embryo formation
A Northwestern University research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to proper embryo formation. view more (2006-07-31)
Mechanism in cells that generate malignant brain tumors may offer target for gene therapy
Researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute who first isolated cancer stem cells in adult brain tumors in 2004 have now identified a molecular mechanism that is involved in the development of these cells from which malignant brain tumors may originate. view more (2008-10-27)
Researchers identify new anti-tumor gene
Researchers from Virginia Commonwealth University have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in 90 percent of human cancers. The discovery could one day lead to an effective gene therapy for cancer. view more (2008-12-17)
Drug attacks prostate cancer in mouse model by destroying its blood supply
A medication used to treat other types of cancer strangles drug-resistant, metastatic prostate cancer by cutting off its blood supply. view more (2006-06-07)
Fluorescent cancer cells to guide brain surgeons
Gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. Gliomas are often resistant to chemotherapy. view more (2009-04-06)
Gene therapy completely suppresses ovarian cancer growth in animal model
University of Pittsburgh School of Medicine researchers have used gene therapy to either completely abolish or significantly inhibit tumor progression in a mouse model of ovarian cancer. view more (2006-06-05)
What's the role of beta-catenin in colorectal cancers?
Beta-catenin, a central molecule of the Wnt-signaling pathway was previously known to involve in the tumorigenesis of various gastrointestinal cancers such as gastric cancer and colon cancer. view more (2008-11-03)
Gene signature helps predict breast cancer prognosis
Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer. view more (2009-05-20)
Cancer researchers describe gene that halts spread of aggressive childhood cancer
A team of cancer researchers has shown that a gene commonly lost during neuroblastoma tumor formation, one of the most aggressive cancers in babies and children, is in fact a "metastasis suppressor" gene. view more (2006-01-05)
Cancer immunoresistance linked to loss of tumor suppressor gene
Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by Andrew T. Parsa, MD, PhD, assistant professor of neurological surgery at the University of California, San Francisco. view more (2006-12-11)
Abnormal overexpression of p53 is a predictive molecular biomarker
A common laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers now has been found to predict a good prognosis with treatment of p53 tumor suppressor gene therapy-making it potentially the first predictive biomarker test for a gene-based drug. view more (2006-09-15)
NCI-Penn Collaboration Finds Targeted Immune Cells Shrink Tumors in Mice
Researchers have generated altered immune cells that are able to shrink, and in some cases eradicate, large tumors in mice. view more (2009-02-11)
Genes that both extend life and protect against cancer identified
A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal "Nature Genetics" identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm. view more (2007-10-15)
MicroRNAs Can Be Tumor Suppressors
University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies. view more (2007-04-26)
Unique estrogen receptor linked to metastatic breast cancer
Breast cancer awareness month may have passed, but researchers remain focused on the disease with a new study showing that a unique estrogen receptor found in breast cancer tumors is a predictor of tumor size and metastases. view more (2006-11-01)
KEAP1 Keeps major cancer-promoting protein at bay
A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell. view more (2009-10-12)
Nano-particles Effective in Killing Cancer with One-Two Punch of Chemotherapeutics
Research studies, based at the University of Pennsylvania, demonstrate that biodegradable nano-particles containing two potent cancer-fighting drugs are effective in killing human breast tumors. view more (2006-04-11)
Novel regulation of the common tumor suppressor PTEN
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon, and brain. view more (2007-01-12)
Study raises questions about prostate cancer therapies targeting IGF-1
Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene - p53 - is already compromised, according to new research by investigators at Fred Hutchinson Cancer Research Center. view more (2008-05-01)
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