Ubiquitin Current Events | Ubiquitin News
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Emory scientists discover unique binding method for essential cellular protein ubiquitin
Researchers at Emory University School of Medicine have uncovered new information about the molecular pathway used by ubiquitin, an essential protein that helps regulate the amounts and locations of other proteins within cells. view more (2006-03-24)
The Nobel Prize in Chemistry 2004
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2004 "for the discovery of ubiquitin-mediated protein degradation" jointly to view more (2004-10-06)
Discovery of new protein could provide new understanding of male fertility
Scientists have discovered a new enzyme involved in the degradation of proteins inside cells, a process that helps eliminate or recycle proteins that are no longer needed. view more (2007-08-03)
Quality control mechanism tags defective sperm cells inside the body
Defective sperm cells do not pass through the body unnoticed. A new University of Missouri study provides evidence that the body recognizes and tags defective sperm cells while they undergo maturation in the epididymis, a sperm storage gland attached to the testis. view more (2008-01-24)
MIT finds most complex protein knot ever seen
An MIT team has discovered the most complicated knot ever seen in a protein, and they believe it may be linked to the protein's function as a rescue agent for proteins marked for destruction. view more (2006-09-26)
Discovery in plants suggests entirely new approach to treating human cancers
For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone — auxin — interacts with its hormone receptor, called TIR1. view more (2007-04-05)
Glue inside the cell: Ubiquitin builds up an immune response
Ubiquitin is a small protein, which can be attached to other cellular proteins, a process known as ubiquitination. Discoveries in the 1980 th on a key function of ubiquitination in the regulation of protein degradation where awarded with the Nobel Prize for chemistry in 2004. view more (2007-10-22)
Sugar coupled to protein causes kidneys to save water
Several new mechanisms that are important for the production and transport of water channels to the cell surface of kidneys have been identified by a Dutch researcher. The water channels ensure that water in the body is reused. If these fail to work properly, you urinate too much and dehydrate. The research was a collaborative project between the... view more... (2003-10-10)
Gene-transcription machinery seen poised for action, held in check until needed
For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes. view more (2007-07-26)
Bacterial protein mimics host to cripple defenses
Like a wolf in sheep's clothing, a protein from a disease-causing bacterium slips into plant cells and imitates a key host protein in order to cripple the plant's defenses. view more (2005-12-23)
Study reveals how cells destroy faulty proteins in cystic fibrosis
The cellular system that degrades faulty proteins created by the cystic fibrosis gene has been identified by University of North Carolina at Chapel Hill scientists. view more (2006-08-11)
Muscle atrophy through thick but not thin
During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids. view more (2009-06-08)
CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery to regulate gene activity
During gene transcription - the process inside the nucleus of cells by which DNA, the genetic material, is copied into RNA - a large, ever-changing multiprotein complex is enlisted to assist the DNA-copying enzyme in its challenging job. view more (2008-12-19)
Novel regulation of the common tumor suppressor PTEN
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon, and brain. view more (2007-01-12)
A paradigm shift in immune response regulation
Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together. view more (2009-03-20)
When Proteins Change Partners
Dieter Wolf, M.D., and colleagues at Burnham Institute for Medical Research (Burnham) have illuminated how competition between proteins enhances combinatorial diversity during ubiquitination (the process that marks proteins for destruction). view more (2009-09-14)
Telling axons where to go - and grow
In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg (Germany) describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons. view more (2005-10-03)
Targeting key proteins of carcinogenesis
Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome. The cell labels the proteins it wants to dispose with Ubiquitin (Ub) in order to avoid the unwanted degradation of still needed proteins. view more (2007-06-25)
Gene expression profiling of dengue virus infection in cell lines and patients
Researchers at the Novartis Institute for Tropical Diseases and the Genome Institute of Singapore have identified new host genes associated with dengue virus infection, which may open new avenues to developing a drug to treat the disease. view more (2007-11-07)
Self-digestion as a means of survival
In times of starvation, cells tighten their belts: they start to digest their own proteins and cellular organs. The process - known as autophagy - takes place in special organelles called autophagosomes. view more (2009-02-27)
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