Ubiquitin Current Events | Ubiquitin News | 2
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Protein plays unexpected role protecting chromosome tips
A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell. view more (2009-08-14)
New pathway could present an intervention point for cancer treatment
A new cellular pathway leads to destruction of a protein that promotes growth of breast, prostate and similar cancers and could provide a new avenue through which to pursue treatment of such diseases. view more (2006-01-27)
'Birth control' for centrioles
Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication. view more (2009-01-26)
Proteasome activator enhances survival of Huntington's disease neuronal model cells
To function, each living cell needs both to build new and to degrade old or damaged proteins. To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins. view more (2007-02-28)
Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
Scientists at the University of Pennsylvania School of Veterinary Medicine have identified a protein, ISG15, that inhibits the Ebola virus from budding, the process by which viruses escape from cells and spread to infect neighboring cells. view more (2008-03-04)
Brain enzyme treatment relieves memory lapse in Alzheimer's mice
An enzyme that helps neurons rid themselves of excess or aberrant proteins is required for normal brain function. view more (2006-08-25)
Model for Angelman syndrome developed by University of Texas at Austin biologists
A model for studying the genetics of Angelman syndrome, a neurological disorder that causes mental retardation and other symptoms in one out of 15,000 births, has been developed by biologists at The University of Texas at Austin. view more (2008-08-15)
Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing. view more (2006-05-05)
Conaway Lab Identifies Novel Mechanism for Regulation of Gene Expression
The Stowers Institute's Conaway Lab has demonstrated that an enzyme called Uch37 is kept in check when it is part of a human chromatin remodeling complex, INO80. The results were published in today's issue of Molecular Cell. view more (2008-09-29)
Penn Medicine, CHOP Researchers Demonstrate First Common Genetic Risk Factors for Autism
Researchers have made an important step forward in understanding the complex genetic structure of autism spectrum disorders. view more (2009-04-29)
Researchers zero in on estrogen's role in breast-cancer cell growth
Why do estrogen-dependent breast-cancer cells grow and spread rapidly? Researchers at the University of Illinois at Urbana-Champaign say it may be because estrogen virtually eliminates levels of a vitally important regulatory protein. view more (2005-09-12)
In evolutionary arms race, a bacterium is found that outwits tomato plant's defenses, Cornell study finds
An arms race is under way in the plant world. It is an evolutionary battle in which plants are trying to beef up their defenses against the innovative strategies of pathogens. view more (2007-07-19)
Protein marker associated with positive outcome in invasive breast cancer
Researchers at Sunnybrook and Women's College Health Sciences Centre have found a new protein marker linked to positive outcome in patients with breast cancer. view more (2005-11-16)
An AIDS-related virus tricks cells to become tumors, new Penn study finds
Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth. view more (2006-11-09)
Lipid droplets lead a Spartin existence
Spartin, a protein linked to the neuronal disease Troyer syndrome, was thought to function in endocytosis. In the March 23, 2009 issue of the Journal of Cell Biology (www.jcb.org), Eastman et al. identify an unexpected role for Spartin in regulating the cell's lipid storage depots. view more (2009-03-23)
Unraveling how cells respond to low oxygen
Gary Chiang, Ph.D., and colleagues at Burnham Institute for Medical Research (Burnham) have elucidated how the stability of the REDD1 protein is regulated. view more (2009-08-06)
New research helps explain genetics of Parkinson's disease
A new study by Narendra et al. suggests that Parkin, the product of the Parkinson's disease-related gene Park2, prompts neuronal survival by clearing the cell of its damaged mitochondria. view more (2008-11-24)
Researchers discover how rheumatoid arthritis causes bone loss
Researchers have discovered key details of how rheumatoid arthritis (RA) destroys bone, according to a study published in the Aug. 22 edition of the Journal of Biological Chemistry. view more (2008-08-21)
Proteasome inhibition affects epigenetic mechanisms
Alcohol consumption causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunoresponse defect, and fibrosis. view more (2009-02-19)
SUMO protein guides chromatin remodeler to suppress genes
In an in vitro study, led by Grace Gill, PhD, Tufts University School of Medicine, researchers discovered how a protein called SUMO (Small Ubiquitin-related Modifier) guides an enzyme complex that alters the structure of chromatin to regulate expression of genes. view more (2009-04-28)
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