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Genome circularization and RNA virus replication
As featured on the cover of the August 15th issue of G&D, an Argentinian research team, led by Dr. Andrea Gamarnik, report on their recent discovery of a novel mechanism of dengue virus replication.   view more (2006-08-01)

Gene expression profiling of dengue virus infection in cell lines and patients
Researchers at the Novartis Institute for Tropical Diseases and the Genome Institute of Singapore have identified new host genes associated with dengue virus infection, which may open new avenues to developing a drug to treat the disease.   view more (2007-11-07)

MicroRNAs help control HIV life cycle
Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells.   view more (2009-06-26)

New Strategy for Inhibiting Virus Replication
Viruses need living cells for replication and production of virus progeny. Thus far, antiviral therapy primarily targets viral factors but often induces therapy resistance. New improved therapies attempt to targets cellular factors that are essential for viral replication.    view more (2009-08-17)

Selenium may slow march of AIDS
Increasing the production of naturally occurring proteins that contain selenium in human blood cells slows down multiplication of the AIDS virus, according to biochemists.   view more (2008-12-01)

Visualizing virus replication in 3 dimensions
Dengue fever is the most common infectious disease transmitted by mosquitoes - some 100 million people around the world are infected. Researchers at the Hygiene Institute at Heidelberg University Hospital were the first to present a three-dimensional model of the location in the human cell where the virus is reproduced.   view more (2009-05-08)

Details of the life cycle of SARS coronavirus
A team of scientists studying Severe Acute Respiratory Syndrome (SARS) has, for the first time, described how the SARS virus manufactures several of the materials required for making copies of itself. "It is essential, when you are looking for ways to stop a disease, that you know exactly how viruses make copies of themselves and... view more... (2003-07-08)

Gene-specific Ebola therapies protect non-human primates from lethal disease
Scientists have developed a successful strategy for interfering with Ebola virus infection that protected 75 percent of nonhuman primates exposed to the lethal disease.   view more (2006-01-13)

Computer Models Aid Understanding of Antibody-Dependent Enhancement in Spread of Dengue Fever
Some viruses' ability to exploit the human body's own defenses to increase their replication may be both a blessing and curse, according to the findings of a study conducted by researchers at the Johns Hopkins Bloomberg School of Public Health.   view more (2005-10-17)

Penn Study Identifies How Ebola Virus Avoids the Immune System
Researchers at the University of Pennsylvania School of Medicine have likely found one reason why the Ebola virus is such a powerful, deadly, and effective virus. Using a cell culture model for Ebola virus infection, they have discovered that the virus disables a cellular protein called tetherin that normally can block the spread of virus from... view more... (2009-01-28)

A potential approach to treatment of hepatitis B virus infection
Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA.   view more (2008-09-10)

An unexpected link between coronavirus replication and protein secretion in infected cells
Coronavirus replication is critically linked to two factors within the early secretory pathway, according to new findings by a team of Dutch researchers that are published June 13th in the open-access journal PLoS Pathogens.   view more (2008-06-13)

Human testis harbors HIV-1 in resident immune cells
Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy.   view more (2006-11-27)

HIV pays a price for invisibility
Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine.   view more (2009-04-13)

Features of replication suggest viruses have common themes, vulnerabilities
A study of the reproductive apparatus of a model virus is bolstering the idea that broad classes of viruses - including those that cause important human diseases such as AIDS, SARS and hepatitis C - have features in common that could eventually make them vulnerable to broad-spectrum antiviral agents.   view more (2007-08-14)

New agent strikes at respiratory syncytial virus replication
University of Texas Medical Branch at Galveston researchers have achieved promising results with a potential new weapon against respiratory syncytial virus, the most common cause of infant hospitalization in the United States.   view more (2008-05-06)

DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
For the first time, findings by scientists at the Genome Institute of Singapore (GIS) may be paving the way for more efficient analyses and tests related to the replication of cells, and ultimately, to the better understanding of human biology, such as in stem cell research.   view more (2007-08-16)

Who will recover spontaneously from hepatitis C virus infection
More than 3% of world population is infected with hepatitis C virus (HCV). The outcome of HCV infections is either self recovery or chronic hepatitis, and many of the chronic infections will develop into liver cirrhosis or liver cancer.   view more (2007-08-30)

The hepatitis healing power of blueberry leaves
A chemical found in blueberry leaves has shown a strong effect in blocking the replication of the Hepatitis C virus, opening up a new avenue for treating chronic HCV infections, which affect 200 million people worldwide and can eventually lead to cirrhosis and liver cancer.    view more (2009-08-10)

Penn researchers determine structure of smallpox virus protein bound to DNA
Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA.   view more (2006-08-07)
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