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Microbiotic technology developed for microinjection of zebrafish embryos
Funded by an NSERC Idea to Innovations grant and an Ontario Early Researcher Award, Prof. Yu Sun's group, the Advanced Micro and Nanosystems Laboratory (http://amnl.mie.utoronto.ca) at the University of Toronto (U of T) recently developed a microrobotic technology for automated microinjection of zebrafish embryos. view more (2007-09-12)
Zebrafish provide a model for cancerous melanoma in humans
In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options. view more (2009-05-26)
Fish fend off invading germs with an initial response similar to the one found in people
Since the human response to infection is highly complex, research to understand how people fight infection is facilitated by studying how similar processes occur in simpler organisms. view more (2009-09-24)
Making Blind Zebrafish See
Scientists in the Conway Institute of Biomolecular & Biomedical Research have restored the sight of blind zebrafish whose eyes failed to develop due to a genetic mutation. The findings, published this week in Developmental Biology, are exciting first steps on a long road to understanding eye diseases in humans. Dr. Breandan Kennedy and his... view more... (2004-07-01)
A Fishy Tale
Recently returned from the United States, Dr. Breandan Kennedy will establish the largest Irish facility for the study of zebrafish in the Conway Institute of Biomolecular and Biomedical Research, University College Dublin. These tiny, freshwater fish, typically found in rice paddies or slow-moving streams, can be used to study genetics and... view more... (2003-07-10)
Mutations common to cancer and developmental disorder examined in a novel disease model
New research sheds light on a common link between tumor formation and Costello Syndrome, an inherited developmental disorder in which patients have cardiac defects, mild mental retardation, and face-shape abnormalities. view more (2008-12-22)
Guidance of Primordial Germ Cell Migration by the Chemokine SDF-1
Identification of the molecular cues governing cell migration is of major importance for the understanding of tissue and organ development and for therapy in cases of diseases resulting from aberrant cell movement. Primordial Germ Cell (PGC) migration is a useful model for studying directional cell movement. During embryonic development, PGCs have... view more... (2002-11-27)
A new way to treat colon cancer?
Researchers at University of Utah's Huntsman Cancer Institute have discovered a new target for possible future colon cancer treatments - a molecule that is implicated in 85 percent of colon cancer cases. view more (2006-10-10)
A master mechanism for regeneration?
Biologists long have marveled at the ability of some animals to re-grow lost body parts. Newts, for example, can lose a leg and grow a new one identical to the original. Zebrafish can re-grow fins. view more (2009-10-20)
Insomniac fish shed light on the molecular basis of sleep disorders
Sleep disorders are common and poorly understood. In humans, narcolepsy is a sleep disorder associated with sleepiness, abnormal dreaming, paralysis and insomnia. view more (2007-10-16)
Pitt team finds molecule that regulates heart size by using zebrafish screening model
Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. view more (2009-07-06)
Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
Researchers at the European Molecular Biology Laboratory (EMBL) have generated a digital zebrafish embryo - the first complete developmental blueprint of a vertebrate. With a newly developed microscope scientists could for the first time track all cells for the first 24 hours in the life of a zebrafish. view more (2008-10-10)
Blocking Cancer-Causing Gene Improves Radiation Effectiveness, Jefferson Researchers Find
Inhibiting a particular cancer-causing gene can enhance the cell-killing effects of radiation, a team of radiation oncologists and cancer biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have found. view more (2006-11-09)
Jefferson Researchers Find Nanoparticle Shows Promise in Reducing Radiation Side Effects
With the help of tiny, transparent zebrafish embryos, researchers at the Kimmel Cancer Center at Thomas Jefferson University and Jefferson Medical College are hoping to prove that a microscopic nanoparticle can be part of a "new class of radioprotective agents" that help protect normal tissue from radiation damage just as well as... view more... (2006-11-09)
Cicardian system suffers and protects from prenatal cocaine exposure
Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission. view more (2007-07-11)
Study shows how the zebrafish gets his stripe
Scientists have discovered how the zebrafish (Danio rerio) develops one of its four stripes of pigment cells. view more (2007-09-26)
Oregon researchers discover a mechanism leading to cleft palate
By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries. view more (2008-02-12)
Junk DNA may not be so junky after all
Researchers at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins have invented a cost-effective and highly efficient way of analyzing what many have termed "junk" DNA and identified regions critical for controlling gene function. view more (2006-03-24)
Pol3 mutation disrupts organ growth
The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting. view more (2007-11-27)
Jefferson Scientists Uncover Lethal Gene Mutation Key to Blocking Cholesterol Processing
When Jefferson Medical College researcher Shiu-Ying Ho, Ph.D., and her colleagues first created a mutation that limited the absorption of lipids and cholesterol into the bloodstream in zebrafish, the possibilities seemed endless. view more (2006-04-20)
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